Reference health
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases
1 of 66 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1523/JNEUROSCI.1858-12.2012
RETRACTED: The Complex PrP<sup>c</sup>-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
The 65 checked references that resolve
resolves10.1111/j.1471-4159.2011.07519.x
Proteolytic processing of Alzheimer’s β‐amyloid precursor protein
resolves10.1038/nrneurol.2009.218
The secretases: enzymes with therapeutic potential in Alzheimer disease
resolves10.1038/42257
Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
resolves10.1073/pnas.95.21.12683
Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice
resolves10.1074/jbc.M111.286195
A Naturally Occurring C-terminal Fragment of the Prion Protein (PrP) Delays Disease and Acts as a Dominant-negative Inhibitor of PrPSc Formation
resolves10.1074/jbc.M105677200
The Disintegrins ADAM10 and TACE Contribute to the Constitutive and Phorbol Ester-regulated Normal Cleavage of the Cellular Prion Protein
resolves10.1074/jbc.273.43.27765
Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor
resolves10.1016/S0304-3940(99)00929-5
Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients
resolves10.1074/jbc.M400793200
Calpain-dependent Endoproteolytic Cleavage of PrPSc Modulates Scrapie Prion Propagation
resolves10.1126/science.1214400
Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE
resolves10.1111/j.1471-4159.2009.06176.x
Cellular prion protein coupling to TACE‐dependent TNF‐α shedding controls neurotransmitter catabolism in neuronal cells
resolves10.1074/jbc.275.13.9186
Regulation by Neurotransmitter Receptors of Serotonergic or Catecholaminergic Neuronal Cell Differentiation
resolves10.1074/jbc.M802433200
Prions Impair Bioaminergic Functions through Serotonin- or Catecholamine-derived Neurotoxins in Neuronal Cells
resolves10.1128/JVI.01502-07
Prion Strain- and Species-Dependent Effects of Antiprion Molecules in Primary Neuronal Cultures
resolves10.1016/S0898-6568(01)00262-5
TNF receptor subtype signalling: Differences and cellular consequences
resolves10.1073/pnas.0509719103
Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation
resolves10.1038/cddis.2012.195
Pathogenic prions deviate PrPC signaling in neuronal cells and impair A-beta clearance
resolves10.1073/pnas.1008969108
Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells
resolves10.1038/nature07761
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
resolves10.1002/emmm.201000088
Prion protein in Alzheimer's pathogenesis: a hot and controversial issue
resolves10.1126/science.274.5284.99
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
resolves10.1523/JNEUROSCI.21-02-00372.2001
Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease
resolves10.1371/journal.pone.0031310
Small-Animal PET Imaging of Amyloid-Beta Plaques with [11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease
resolves10.1016/j.bbr.2010.08.033
Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice
resolves10.1016/S0896-6273(03)00434-3
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
resolves10.1523/JNEUROSCI.1202-06.2006
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
resolves10.1083/jcb.200409127
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth
resolves10.1038/sj.emboj.7601930
The two faces of protein misfolding: gain‐ and loss‐of‐function in neurodegenerative diseases
resolves10.1074/jbc.M602774200
Overstimulation of PrPC Signaling Pathways by Prion Peptide 106-126 Causes Oxidative Injury of Bioaminergic Neuronal Cells
resolves10.1038/nn.3178
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
resolves10.1126/science.1090187
Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis
resolves10.1523/JNEUROSCI.4580-03.2004
Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-β Protein-Induced Neuron Death
resolves10.1083/jcb.200705042
Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice
resolves10.1016/S0006-8993(97)00067-X
Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations
resolves10.1016/S0736-5748(00)00012-5
Induction of cytokines in glial cells surrounding cortical β‐amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology
resolves10.1016/j.bbi.2004.01.004
The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease
resolves10.1212/WNL.0b013e3181b6bb95
Systemic inflammation and disease progression in Alzheimer disease
resolves10.1016/j.neuroscience.2009.02.072
Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy
resolves10.1126/science.1193692
MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants
resolves10.1097/WNR.0b013e328058678d
Simvastatin treatment prolongs the survival of scrapie-infected mice
resolves10.1126/science.1217697
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
resolves10.1096/fj.11-185579
Neuritogenesis: the prion protein controls β1 integrin signaling activity
resolves10.1093/jnci/dji427
Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis
resolves10.1016/S1286-4579(99)80514-0
Prion protein and neuronal differentiation: quantitative analysis of gene expression in a murine inducible neuroectodermal progenitor
resolves10.1002/cne.20117
Prion protein (PrP<sup>c</sup>) immunocytochemistry and expression of the green fluorescent protein reporter gene under control of the bovine PrP gene promoter in the mouse brain
resolves10.1002/dneu.20366
BAX contributes to Doppel‐induced apoptosis of prion‐protein–deficient Purkinje cells
resolves10.1074/jbc.271.16.9690
Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains
resolves10.1242/jcs.02357
ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking
resolves10.1083/jcb.113.1.123
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
resolves10.1016/j.ab.2011.03.013
Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays
resolves10.1016/j.jneumeth.2004.04.001
Manipulation of PrPres production in scrapie-infected neuroblastoma cells
resolves10.1016/j.jchemneu.2006.08.001
Proliferative activity in the frog brain: A PCNA-immunohistochemistry analysis
resolves10.1016/0165-5728(88)90108-7
Expression of a developmental stage-specific antigen by neuronal precursor cells of human fetal cerebellum
resolves10.1074/jbc.M111.246561
β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice
The 2 references without a DOI — listed, not checked
no DOI — not checkedD'Alessio, A. et al. Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells. J. Cell Mol. Med. 16, 627–636 (2012).
no DOI — not checkedSlot, J.W. & Geuze, H.J. A new method of preparing gold probes for multiple-labeling cytochemistry. Eur. J. Cell Biol. 38, 87–93 (1985).
What this badge says. CiteStamped means the CHECKABLE references of this
work were clean at the dated check: each resolved to a known work in a public registry, and none
carried a retraction notice at that time. It says nothing about the quality, findings,
or importance of the work itself, and nothing about references deposited without a DOI.
checked 2026-07-22 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record
Embed this badge
Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.
<a href="https://citestamp.com/citestamped/10.1038/nm.3302"><img src="https://citestamp.com/citestamped/10.1038/nm.3302/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>
[](https://citestamp.com/citestamped/10.1038/nm.3302)