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Somatostatin regulates brain amyloid β peptide Aβ42 through modulation of proteolytic degradation

https://doi.org/10.1038/nm1206
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26/26 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 26 checked references that resolve
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Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging
resolves10.1038/nature02661
Gene regulation and DNA damage in the ageing human brain
resolves10.1038/288279a0
Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa
resolves10.1007/s00401-002-0551-7
Interstitial cells subjacent to the entorhinal region expressing somatostatin-28 immunoreactivity are susceptible to development of Alzheimer's disease-related cytoskeletal changes
resolves10.1126/science.1072994
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
resolves10.1038/72237
Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
resolves10.1126/science.1059946
Metabolic Regulation of Brain Aβ by Neprilysin
resolves10.1002/jnr.10390
Region‐specific reduction of Aβ‐degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
resolves10.1016/S0304-3940(00)01675-X
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide
resolves10.1016/S0896-6273(03)00787-6
Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death
resolves10.1523/JNEUROSCI.4792-03.2004
Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain
resolves10.1016/S0008-6363(98)00192-8
Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction
resolves10.1182/blood.V98.9.2697
Negative feedback on the effects of stem cell factor on hematopoiesis is partly mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study
resolves10.1074/jbc.M401891200
Effects of Neprilysin Chimeric Proteins Targeted to Subcellular Compartments on Amyloid β Peptide Clearance in Primary Neurons
resolves10.1074/jbc.M008511200
Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases
resolves10.1016/S0006-8993(01)02563-X
Impairment in motor learning of somatostatin null mutant mice
resolves10.1172/JCI119225
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
resolves10.1016/S0005-2736(03)00235-9
Somatostatin receptors
resolves10.1038/28190
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
resolves10.1073/pnas.89.23.11151
Molecular cloning and functional expression of a brain-specific somatostatin receptor.
resolves10.1517/13543784.13.1.69
The potential of activation of somatostatinergic neurotransmission with FK960 in Alzheimer’s disease
resolves10.1093/oxfordjournals.jbchem.a003040
Clearance of Extracellular and Cell-Associated Amyloid   Peptide through Viral Expression of Neprilysin in Primary Neurons
resolves10.1523/JNEUROSCI.09-12-04439.1989
Histochemical visualization of neutral endopeptidase-24.11 (enkephalinase) activity in rat brain: cellular localization and codistribution with enkephalins in the globus pallidus
resolves10.1093/oxfordjournals.jbchem.a022733
Four Types of Calpastatin Isoforms with Distinct Amino-Terminal Sequences Are Specified by Alternative First Exons and Differentially Expressed in Mouse Tissues
resolves10.1002/cne.10700
Patterns of expression of neuropeptides in GABAergic nonprincipal neurons in the mouse hippocampus: Quantitative analysis with optical disector
resolves10.1006/meth.1999.0813
Tyramide Signal Amplification Method in Multiple-Label Immunofluorescence Confocal Microscopy
The 3 references without a DOI — listed, not checked
no DOI — not checkedGarcia-Jimenez, A., Fastbom, J., Winbland, B. & Cowburn, R.F. G-protein regulation of signal transduction in Alzheimer's disease. Brain Aging 2, 7–15 (2002).
no DOI — not checkedCitron, M. β-Secretase: progress and open questions. in Aβ Metabolism and Alzheimer's Disease. (ed. Saido, T.C.) 17–25 (Landes Bioscience, Georgetown, 2003).
no DOI — not checkedWolfe, M.S. γ-Secretase and presenilin. in Aβ Metabolism and Alzheimer's Disease. (ed. Saido, T.C.) 33–47 (Landes Bioscience, Georgetown, 2003).
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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