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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

https://doi.org/10.1038/nm1477
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28/28 checkable references clean · checked 2026-09-04

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 28 checked references that resolve
resolves10.1056/NEJMoa040419
Avian Influenza A (H5N1) in 10 Patients in Vietnam
resolves10.3201/eid1102.041061
Human Disease from Influenza A (H5N1), Thailand, 2004
resolves10.1128/JVI.79.4.2191-2198.2005
Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004
resolves10.1128/JVI.79.18.11788-11800.2005
Avian Influenza (H5N1) Viruses Isolated from Humans in Asia in 2004 Exhibit Increased Virulence in Mammals
resolves10.1086/432008
Virulence May Determine the Necessary Duration and Dosage of Oseltamivir Treatment for Highly Pathogenic A/Vietnam/1203/04 Influenza Virus in Mice
resolves10.1038/nm757
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
resolves10.1016/S0140-6736(02)11772-7
Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
resolves10.1099/vir.0.80663-0
Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses
resolves10.1186/1465-9921-6-135
Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
resolves10.1016/j.virol.2006.03.048
Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam
resolves10.1126/science.1121586
Large-Scale Sequence Analysis of Avian Influenza Isolates
resolves10.1126/science.1062882
Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses
resolves10.1073/pnas.0507415102
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
resolves10.1084/jem.20051938
The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
resolves10.1056/NEJMra052211
Avian Influenza A (H5N1) Infection in Humans
resolves10.1056/NEJMoa044307
Fatal Avian Influenza A (H5N1) in a Child Presenting with Diarrhea Followed by Coma
resolves10.3201/eid1206.060227
H5N1 Influenza A Virus and Infected Human Plasma
resolves10.1002/1096-9071(200103)63:3<242::AID-JMV1007>3.0.CO;2-N
Pathology of fatal human infection associated with avian influenza A H5N1 virus
resolves10.1016/S0140-6736(04)15595-5
Re-emergence of fatal human influenza A subtype H5N1 disease
resolves10.1128/JVI.74.13.6105-6116.2000
Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans
resolves10.1086/500954
Functional Tumor Necrosis Factor–Related Apoptosis‐Inducing Ligand Production by Avian Influenza Virus–Infected Macrophages
resolves10.4049/jimmunol.162.6.3549
The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells
resolves10.1165/ajrcmb.10.2.8110469
Increased Expression of the Monocyte Chemoattractant Protein-1 in Bronchial Tissue from Asthmatic Subjects
resolves10.1016/1043-4666(92)90025-M
Interleukin 8 (IL-8) in the bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome (ARDS) and patients at risk for ARDS
resolves10.1111/j.1365-2249.2004.02448.x
What does the peripheral blood tell you in SARS?
resolves10.1056/NEJMoa054512
Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection
resolves10.1128/jcm.28.3.495-503.1990
Rapid and simple method for purification of nucleic acids
resolves10.1073/pnas.132268999
Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR
The 1 reference without a DOI — listed, not checked
no DOI — not checkedChen, H. et al. Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control. Proc. Natl. Acad. Sci. USA (2006).
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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