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Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

https://doi.org/10.1038/nmat2859
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25/25 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 25 checked references that resolve
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Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target
resolves10.1002/art.20009
Tuberculosis infection in patients with rheumatoid arthritis and the effect of infliximab therapy
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Safety of Infliximab and Other Biologic Agents in the Inflammatory Bowel Diseases
resolves10.1111/j.1445-5994.2009.001999.x
Pulmonary toxicity associated with infliximab therapy for ulcerative colitis
resolves10.1038/nature07774
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
resolves10.1016/j.jconrel.2007.08.008
5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease
resolves10.1163/156856208786440479
Engineering strategies to enhance nanoparticle-mediated oral delivery
resolves10.1007/BF02093613
Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease
resolves10.1016/0016-5085(92)91112-H
Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease
resolves10.1136/gut.34.9.1191
Increased production of luminol enhanced chemiluminescence by the inflamed colonic mucosa in patients with ulcerative colitis.
resolves10.1016/0957-4166(96)00040-7
Enantio and diastereoselectivity of cyclohexanone monooxygenase catalyzed oxidation of 1,3-dithioacetals
resolves10.1136/gut.30.10.1362
Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease.
resolves10.1016/S1074-7613(00)80038-2
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements
resolves10.1016/S0022-2836(03)00181-5
Gene Silencing by Systemic Delivery of Synthetic siRNAs in Adult Mice
resolves10.1016/S0006-291X(02)00736-2
Gene silencing in mammalian cells by preformed small RNA duplexes
resolves10.1016/j.jconrel.2007.11.017
Anti-tumor effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice
resolves10.1038/nature04263
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
resolves10.1172/JCI33494
Nonviral delivery of synthetic siRNAs in vivo
resolves10.1016/j.jconrel.2007.07.016
Cationic lipids and polymers mediated vectors for delivery of siRNA
resolves10.1016/S0168-3659(01)00412-6
Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?
resolves10.1007/s11095-005-8418-y
Design of Estradiol Loaded PLGA Nanoparticulate Formulations: A Potential Oral Delivery System for Hormone Therapy
resolves10.1023/A:1016085108889
Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size
resolves10.1023/A:1011032328064
Size-Dependent Bioadhesion of Micro- and Nanoparticulate Carriers to the Inflamed Colonic Mucosa
resolves10.1371/journal.pone.0006073
Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis
resolves10.1038/nprot.2007.41
Chemically induced mouse models of intestinal inflammation
The 3 references without a DOI — listed, not checked
no DOI — not checkedKountouras, J., Chatzopoulos, D. & Zavos, C. Reactive oxygen metabolites and upper gastrointestinal diseases. Hepatogastroenterology 48, 743–751 (2001).
no DOI — not checkedPeng, Y. C. et al. Chemiluminescence assay of mucosal reactive oxygen species in gastric cancer, ulcer and antral mucosa. Hepatogastroenterology 55, 770–773 (2008).
no DOI — not checkedShukla, A. K., Verma, M. & Singh, K. N. Superoxide induced deprotection of 1,3-dithiolanes: A convenient method of dedithioacetalization. Indian J. Chem. B 43, 1748–1752 (2004).
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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