Reference health
Drugs for bad bugs: confronting the challenges of antibacterial discovery
26/26 checkable references clean · checked 2026-08-03
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
8 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 26 checked references that resolve
resolves10.1086/499819
Bad Bugs Need Drugs: An Update on the Development Pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America
resolves10.1128/JB.185.6.2051-2058.2003
Characterization of a Novel Fucose-Regulated Promoter (P<sub><i>fcsK</i></sub>) Suitable for Gene Essentiality and Antibacterial Mode-of-Action Studies in<i>Streptococcus pneumoniae</i>
resolves10.1016/S0378-1119(00)00325-5
Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action
resolves10.1517/phgs.5.1.101.25679
Identification of Antimicrobial Targets Using a Comprehensive Genomic Approach
resolves10.1159/000076741
A Global Approach to Identify Novel Broad-Spectrum Antibacterial Targets among Proteins of Unknown Function
resolves10.1021/jm025502x
Nanomolar Inhibitors of <i>Staphylococcus </i><i>a</i><i>ureus</i> Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
resolves10.1128/AAC.46.10.3118-3124.2002
Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents
resolves10.1128/AAC.46.11.3343-3347.2002
Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of<i>Staphylococcus aureus</i>
resolves10.1128/AAC.47.6.1784-1789.2003
Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of
<i>Streptococcus pneumoniae</i>
with Two Distinct Methionyl-tRNA Synthetase Genes
resolves10.1128/JB.182.15.4146-4152.2000
Two Active Forms of UDP-
<i>N</i>
-Acetylglucosamine Enolpyruvyl Transferase in Gram-Positive Bacteria
resolves10.1126/science.1106753
A Diarylquinoline Drug Active on the ATP Synthase of
<i>Mycobacterium tuberculosis</i>
resolves10.1021/ja983468z
Engineering a Cell-Free Murein Biosynthetic Pathway: Combinatorial Enzymology in Drug Discovery
resolves10.1038/nbt0502-478
An array of target-specific screening strains for antibacterial discovery
resolves10.1021/ci0200467
Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry
resolves10.1016/S0169-409X(96)00423-1
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
resolves10.1002/1439-7633(20020301)3:2/3<124::AID-CBIC124>3.0.CO;2-J
Combinatorial Biosynthesis of Antibiotics: Challenges and Opportunities
resolves10.1046/j.1365-2958.2000.01725.x
A genomic analysis of two‐component signal transduction in <i>Streptococcus pneumoniae</i>
resolves10.1126/science.1063566
Identification of Critical Staphylococcal Genes Using Conditional Phenotypes Generated by Antisense RNA
The 8 references without a DOI — listed, not checked
no DOI — not checkedHouse of Lords Select Committee on Science and Technology Seventh Report. Resistance to Antibiotics and Other Antimicrobial Agents
[online]
, (Stationary Office, London, UK, 1998).
no DOI — not checkedShlaes, D. M. et al. Antibiotic discovery: state of the state. ASM News 70, 275–281 (2004).
no DOI — not checkedInfectious Disease Society of America. Bad Bugs, No Drugs
[online]
, (2004). Seminal review by key opinion leaders on the shrinking investment by big pharma in antibacterial discovery, and the growing challenge of resistant pathogens.
no DOI — not checkedTickell, S. The Antibiotic Innovation Study: Expert Voices on a Critical Need
[online]
, (2005).
no DOI — not checkedKaplan, W. & Laing, R. Priority Medicines for Europe and the World
[online]
, (World Health Organization, Geneva, 2004).
no DOI — not checkedPayne, D. J., Gwynn, M. N., Holmes, D. J. & Rosenberg, M. Genomic approaches to antibacterial discovery. Methods Mol. Biol. 266, 231–259 (2004).
no DOI — not checkedChan, P. F. et al. Finding the gems using genomic discovery: antibacterial drug discovery strategies — the successes and the challenges. Drug Discov. Today: Ther. Strategies 1, 519–527 (2004)
no DOI — not checkedWong, K. K. & Pompliano, D. L. in Resolving the Antibiotic Paradox: Progress in Understanding Drug Resistance and Development of New Antibiotics (eds Rosen, B. P. & Mobashery, S.) (Plenum, New York, 1999)
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