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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

125/125 checkable references clean · checked 2026-07-23

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The 125 checked references that resolve

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Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System

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Muscarinic Receptors—Characterization, coupling and function

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Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

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Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

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Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M 4 muscarinic acetylcholine receptor knockout mice

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Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M 3 subtype

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

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Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1Muscarinic Acetylcholine Receptor

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Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice

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Cholinergic dilation of cerebral blood vessels is abolished in M 5 muscarinic acetylcholine receptor knockout mice

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Muscarinic Induction of Hippocampal Gamma Oscillations Requires Coupling of the M1 Receptor to Two Mixed Cation Currents

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Increased drinking in mutant mice with truncated M5 muscarinic receptor genes

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Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4

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Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus

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Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2‐mediated direct suppression and M1/M3‐mediated indirect suppression through endocannabinoid signalling

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M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice

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Mice Lacking M2and M3Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable

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A critical role for β cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

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Thiochrome Enhances Acetylcholine Affinity at Muscarinic M4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

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Snake toxins with high selectivity for subtypesof muscarinic acetylcholine receptors

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Discovery of an Ectopic Activation Site on the M1Muscarinic Receptor

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Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M1 Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric Agonist

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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- <scp>d</scp> -aspartate receptor activity

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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine

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Cholinergic Agonists and the Treatment of Alzheimers Disease

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M1 Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy

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M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice

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Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- <scp>d</scp> -aspartate (NMDA) receptor currents in hippocampal pyramidal cells

resolves10.1016/0024-3205(93)90300-R

Immunological localization of m1–m5 muscarinic acetylcholine receptors in peripheral tissues and brain

resolves10.1074/jbc.M011563200

The M1 Receptor Is Required for Muscarinic Activation of Mitogen-activated Protein (MAP) Kinase in Murine Cerebral Cortical Neurons

resolves10.1006/mcne.2001.1042

M1 Muscarinic Acetylcholine Receptors Activate Extracellular Signal-Regulated Kinase in CA1 Pyramidal Neurons in Mouse Hippocampal Slices

resolves10.1146/annurev.pharmtox.42.082701.145401

Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

resolves10.1523/JNEUROSCI.2338-05.2005

Modulation of Synaptic Plasticity by Physiological Activation of M1Muscarinic Acetylcholine Receptors in the Mouse Hippocampus

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Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex

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Decreased Input-Specific Plasticity of the Auditory Cortex in Mice Lacking M1 Muscarinic Acetylcholine Receptors

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M2Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

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Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice

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Muscarinic receptors involved in hippocampal plasticity

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Characterization of Central Inhibitory Muscarinic Autoreceptors by the Use of Muscarinic Acetylcholine Receptor Knock-Out Mice

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Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired

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Antisense oligodeoxynucleotides against the muscarinic m2, but not m4, receptor supports its role as autoreceptors in the rat hippocampus

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SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals

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Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788

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Long-term effects of BIBN-99, a selective muscarinic M2 receptor antagonist, on improving spatial memory performance in aged cognitively impaired rats

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Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

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The current status of the dopamine hypothesis of schizophrenia

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Towards a muscarinic hypothesis of schizophrenia

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Muscarinic Receptors as a Target for Drugs Treating Schizophrenia

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Altered Hippocampal Muscarinic M4, but Not M1, Receptor Expression from Subjects with Schizophrenia

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Elucidating the role of muscarinic receptors in psychosis

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M 4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related central nervous system pathologies

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Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice

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Decreased Amphetamine-Induced Locomotion and Improved Latent Inhibition in Mice Mutant for the M5 Muscarinic Receptor Gene Found in the Human 15q Schizophrenia Region

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Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area

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M5 Muscarinic Receptors Are Required for Prolonged Accumbal Dopamine Release after Electrical Stimulation of the Pons in Mice

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Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry

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Deletion of the M 5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia

resolves10.1002/jnr.10728

Role for M5 muscarinic acetylcholine receptors in cocaine addiction

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Reduced Cocaine Self-Administration in Muscarinic M5Acetylcholine Receptor-Deficient Mice

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Butylthio[2.2.2] (NNC 11–1053/LY297802): An Orally Active Muscarinic Agonist Analgesic

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Functional Activity of the M2 and M4 Receptor Subtypes in the Spinal Cord Studied with Muscarinic Acetylcholine Receptor Knockout Mice

resolves10.1523/JNEUROSCI.21-09-03295.2001

Excitatory Nicotinic and Desensitizing Muscarinic (M2) Effects on C-Nociceptors in Isolated Rat Skin

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Muscarinic M2 receptors inhibit heat-induced CGRP release from isolated rat skin

resolves10.1523/JNEUROSCI.22-12-j0002.2002

Muscarinic M2 Receptors on Peripheral Nerve Endings: A Molecular Target of Antinociception

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M2 and M4 Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro

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Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M 2 or M 3 muscarinic acetylcholine receptors

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Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

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Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes

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Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neurons

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Muscarinic receptor subtypes in airways

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Thromboxane A2induces airway constriction through an M3muscarinic acetylcholine receptor-dependent mechanism

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Muscarinic receptors in the bladder: from basic research to therapeutics

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M3-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea

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Muscarinic Receptor Knockout Mice: Role of Muscarinic Acetylcholine Receptors M2, M3, and M4 in Carbamylcholine-Induced Gallbladder Contractility

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M2 and M3 muscarinic receptor‐mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice

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Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: Studies with muscarinic receptor knockout mice

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Roles of M2and M3muscarinic receptors in cholinergic nerve‐induced contractions in mouse ileum studied with receptor knockout mice

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Increased Relaxant Action of Forskolin and Isoproterenol against Muscarinic Agonist-Induced Contractions in Smooth Muscle from M2 Receptor Knockout Mice

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Drug effects on salivary glands: dry mouth

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The management of Sjögren's syndrome

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Understanding salivary fluid and protein secretion

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Cholinergic Stimulation of Salivary Secretion Studied with M1 and M3 Muscarinic Receptor Single- and Double-Knockout Mice

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Use of Muscarinic Agonists in the Treatment of Sjögren's Syndrome

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Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice

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Cholinergically stimulated gastric acid secretion is mediated by M3 and M5 but not M1 muscarinic acetylcholine receptors in mice

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Muscarinic receptor subtypes in neuronal and non‐neuronal cholinergic function

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The Non-neuronal Cholinergic System of Human Skin

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Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes

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Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors

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Autonomic regulation of islet hormone secretion - Implications for health and disease

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Muscarinic Stimulation of Pancreatic Insulin and Glucagon Release Is Abolished in M3 Muscarinic Acetylcholine Receptor–Deficient Mice

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Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses

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CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians

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GPCR interacting proteins (GIP)

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Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

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New insights into sympathetic regulation of glucose and fat metabolism

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Up-Regulated PAR-2-Mediated Salivary Secretion in Mice Deficient in Muscarinic Acetylcholine Receptor Subtypes

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no DOI — not checkedGilon, P. & Henquin, J. C. Mechanisms and physiological significance of the cholinergic control of pancreatic β-cell function. Endocr. Rev. 22, 565–604 (2001).

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