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Assembly and localization of Toll-like receptor signalling complexes
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Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
The 112 checked references that resolve
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Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands
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Ligand-induced conformational changes allosterically activate Toll-like receptor 9
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Conserved Features in the Extracellular Domain of Human Toll-like Receptor 8 Are Essential for pH-dependent Signaling
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Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner
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Characterizing the Protonation State of Cytosine in Transient G·C Hoogsteen Base Pairs in Duplex DNA
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Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase
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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA
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Cytokine Spätzle binds to the
<i>Drosophila</i>
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Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spätzle
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The Ectodomain of the Toll-like Receptor 4 Prevents Constitutive Receptor Activation
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Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor
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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
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Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from the Brucella Protein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry
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The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer
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Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
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Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in
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Spatiotemporal Mobilization of Toll/IL-1 Receptor Domain-Containing Adaptor Molecule-1 in Response to dsRNA
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Distinct roles of TIR and non‐TIR regions in the subcellular localization and signaling properties of MyD88
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Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling
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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
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Trif-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling
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A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins
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Cutting Edge: Differential Inhibition of TLR Signaling Pathways by Cell-Permeable Peptides Representing BB Loops of TLRs
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TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules
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Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population
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Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain
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An Alanine-to-Proline Mutation in the BB-Loop of TLR3 Toll/IL-1R Domain Switches Signalling Adaptor Specificity from TRIF to MyD88
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The TLR3 signaling complex forms by cooperative receptor dimerization
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An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4
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What the Myddosome structure tells us about the initiation of innate immunity
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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling
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Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4
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The Role of Intermediary Domain of MyD88 in Cell Activation and Therapeutic Inhibition of TLRs
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Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
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IRAK‐M mediates Toll‐like receptor/IL‐1R‐induced NFκB activation and cytokine production
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TLR9 Activation Induces Normal Neutrophil Responses in a Child with IRAK-4 Deficiency: Involvement of the Direct PI3K Pathway
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Functional assessment of the mutational effects of human IRAK4 and MyD88 genes
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Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling
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Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube
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A Molecular Mechanism for Toll-IL-1 Receptor Domain-containing Adaptor Molecule-1-mediated IRF-3 Activation
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RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation
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Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway
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The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins
resolves10.1073/pnas.1116302108
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway
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Cutting Edge: TNFR-Associated Factor (TRAF) 6 Is Essential for MyD88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β (TRIF)-Dependent Pathway in TLR Signaling
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Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling
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Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency
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Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis
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Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
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Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells
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A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
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A Protein Associated with Toll-Like Receptor 4 (PRAT4A) Regulates Cell Surface Expression of TLR4
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Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
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Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
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MD-2 and TLR4 N-Linked Glycosylations Are Important for a Functional Lipopolysaccharide Receptor
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The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane
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Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane
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The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes
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Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity
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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
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Cholesterol Levels Modulate EGF Receptor-Mediated Signaling by Altering Receptor Function and Trafficking
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T-Cell Receptor Microclusters Critical for T-Cell Activation Are Formed Independently of Lipid Raft Clustering
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Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K
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Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling
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Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol
resolves10.1016/j.cell.2014.01.019
A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction
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Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
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Ultra-High Resolution Imaging by Fluorescence Photoactivation Localization Microscopy
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Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies
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A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
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Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures
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The Crystal Structure of the BAR Domain from Human Bin1/Amphiphysin II and Its Implications for Molecular Recognition
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