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MAPK cascade signalling and synaptic plasticity

126/126 checkable references clean · checked 2026-09-07

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The 126 checked references that resolve

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Activation of Ras by receptor tyrosine kinases.

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MAP kinase activator from insulin‐stimulated skeletal muscle is a protein threonine/tyrosine kinase.

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Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.

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Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

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MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

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MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts

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Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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Activation of p42 Mitogen‐Activated Protein Kinase by Glutamate Receptor Stimulation in Rat Primary Cortical Cultures

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Activation of Mitogen‐Activated Protein Kinase in Cultured Rat Hippocampal Neurons by Stimulation of Glutamate Receptors

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Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism

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Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

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Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide

resolves10.1016/S0092-8674(02)00897-8

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

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Control of Ras cycling by Ca2+

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Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

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A synthetic inhibitor of the mitogen-activated protein kinase cascade.

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PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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The specificities of protein kinase inhibitors: an update

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Long-Term Potentiation--A Decade of Progress?

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A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

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Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

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The MAPK cascade is required for mammalian associative learning

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Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

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Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

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Inducible, pharmacogenetic approaches to the study of learning and memory

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Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

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A Role for ERK MAP Kinase in Physiologic Temporal Integration in Hippocampal Area CA1

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The Extracellular Signal-Regulated Kinase Cascade Is Required for NMDA Receptor-Independent LTP in Area CA1 But Not Area CA3 of the Hippocampus

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P42/44 MAP Kinase Inhibitor PD98059 Attenuates Multiple Forms of Synaptic Plasticity in Rat Dentate Gyrus In Vitro

resolves10.1523/JNEUROSCI.20-17-06317.2000

Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation

resolves10.1523/JNEUROSCI.20-21-08177.2000

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

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Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

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Requirement of ERK Activation for Visual Cortical Plasticity

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Requirement for Mitogen-activated Protein Kinase in Cerebellar Long Term Depression

resolves10.1523/JNEUROSCI.23-09-03679.2003

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms

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A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

resolves10.1101/lm.6.5.478

A Necessity for MAP Kinase Activation in Mammalian Spatial Learning

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Extracellular Signal-Regulated Kinase Activity in the Entorhinal Cortex Is Necessary for Long-Term Spatial Memory

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Specific and Differential Activation of Mitogen-Activated Protein Kinase Cascades by Unfamiliar Taste in the Insular Cortex of the Behaving Rat

resolves10.1126/science.287.5461.2262

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

resolves10.1016/S0896-6273(01)00194-5

Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

resolves10.1016/S0092-8674(01)00321-X

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

resolves10.1038/19978

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

resolves10.1038/46574

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

resolves10.1002/bies.10057

A fresh look at the role of CaMKII in hippocampal synaptic plasticity and memory

resolves10.1038/nrn753

The molecular basis of CaMKII function in synaptic and behavioural memory

resolves10.1523/JNEUROSCI.22-09-03359.2002

Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region

resolves10.1016/S0896-6273(03)00228-9

Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons

resolves10.1038/83976

Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology

resolves10.1046/j.1460-9568.2003.02694.x

Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons

resolves10.1523/JNEUROSCI.20-12-04563.2000

The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate GyrusIn Vivo

resolves10.1523/JNEUROSCI.21-02-j0002.2001

Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Activation in Somatodendritic Compartments: Roles of Action Potentials, Frequency, and Mode of Calcium Entry

resolves10.1523/JNEUROSCI.22-12-04860.2002

Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway

resolves10.1523/JNEUROSCI.22-13-05432.2002

The Role of Extracellular Regulated Kinases I/II in Late-Phase Long-Term Potentiation

resolves10.1016/S0896-6273(00)80331-1

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

resolves10.1523/JNEUROSCI.22-13-05412.2002

Serotonin Stimulates Phosphorylation ofAplysiaSynapsin and Alters Its Subcellular Distribution in Sensory Neurons

resolves10.1046/j.1471-4159.2000.0752277.x

The A‐Type Potassium Channel Kv4.2 Is a Substrate for the Mitogen‐Activated Protein Kinase ERK

resolves10.1016/S0896-6273(03)00404-5

Rap1 Couples cAMP Signaling to a Distinct Pool of p42/44MAPK Regulating Excitability, Synaptic Plasticity, Learning, and Memory

resolves10.1042/bj2880351

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

resolves10.1083/jcb.122.5.1079

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

resolves10.1006/mcne.2002.1188

Phosphorylation of Hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during Contextual Fear Conditioning: Interactions between Erk-1/2 and Elk-1

resolves10.1002/mrd.1080420414

Transcriptional regulation by MAP kinases

resolves10.1038/nrn987

Regulation of transcription factors by neuronal activity

resolves10.1016/S0896-6273(02)00828-0

Function and Regulation of CREB Family Transcription Factors in the Nervous System

resolves10.1523/JNEUROSCI.23-15-06304.2003

Does cAMP Response Element-Binding Protein Have a Pivotal Role in Hippocampal Synaptic Plasticity and Hippocampus-Dependent Memory?

resolves10.1146/annurev.biochem.68.1.821

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

resolves10.1073/pnas.051634198

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

resolves10.1038/88380

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

resolves10.1128/MCB.18.4.1946

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

resolves10.1126/science.273.5277.959

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

resolves10.1128/MCB.21.1.81-87.2001

Altered Extracellular Signal-Regulated Kinase Signaling and Glycogen Metabolism in Skeletal Muscle from p90 Ribosomal S6 Kinase 2 Knockout Mice

resolves10.1038/384567a0

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

resolves10.1093/hmg/11.23.2929

Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning

resolves10.1126/science.285.5429.886

Requirement of Rsk-2 for Epidermal Growth Factor-Activated Phosphorylation of Histone H3

resolves10.1073/pnas.97.6.2462

Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c- Fos gene

resolves10.1038/nn951

Hippocampal CRE-mediated gene expression is required for contextual memory formation

resolves10.1523/JNEUROSCI.20-11-03993.2000

Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory

resolves10.1523/JNEUROSCI.22-05-01532.2002

Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation ofArcSynthesis

resolves10.1523/JNEUROSCI.21-15-05484.2001

Arg3.1/Arc mRNA Induction by Ca2+and cAMP Requires Protein Kinase A and Mitogen-Activated Protein Kinase/Extracellular Regulated Kinase Activation

resolves10.1038/76615

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

resolves10.1016/0168-0102(95)00902-6

ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain

resolves10.1016/S0006-8993(99)01762-X

Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain

resolves10.1016/S0896-6273(00)81008-9

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

resolves10.1016/S0896-6273(00)80471-7

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

resolves10.1523/JNEUROSCI.20-11-04069.2000

Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry

resolves10.1523/JNEUROSCI.22-22-09721.2002

SynGAP Regulates ERK/MAPK Signaling, Synaptic Plasticity, and Learning in the Complex with Postsynaptic Density 95 and NMDA Receptor

resolves10.1523/JNEUROSCI.23-04-01119.2003

The Role of Synaptic GTPase-Activating Protein in Neuronal Development and Synaptic Plasticity

resolves10.1126/science.7914033

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

resolves10.1016/0092-8674(94)90277-1

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

resolves10.1016/0092-8674(94)90278-X

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

resolves10.1007/s000180050369

The stress-activated protein kinase pathways

resolves10.1002/(SICI)1097-4547(20000601)60:5<623::AID-JNR7>3.0.CO;2-4

Constitutive activity and differential localization of p38? and p38? MAPKs in adult mouse brain

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

resolves10.1016/S1074-5521(98)90170-3

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

resolves10.1074/jbc.272.18.12116

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

resolves10.1021/bi980832y

The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding

resolves10.1006/bbrc.1997.6849

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

resolves10.1523/JNEUROSCI.21-15-05513.2001

The p38 Mitogen-Activated Protein Kinase Is Involved in Associative Learning in Rabbits

resolves10.1016/S0896-6273(01)00355-5

Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP

resolves10.1046/j.1365-2443.2002.00546.x

SPAL, a Rap‐specific GTPase activating protein, is present in the NMDA receptor‐PSD‐95 complex in the hippocampus

resolves10.1038/33451

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

resolves10.1074/jbc.275.5.3722

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase

resolves10.1016/S0959-4388(99)00010-0

Extracellular-signal-regulated kinase signalling in neurons

resolves10.1046/j.1460-9568.1999.00609.x

Raf‐1 and B‐Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain

resolves10.1126/stke.2002.162.pe49

Hitting the Target: Emerging Technologies in the Search for Kinase Substrates

resolves10.1038/86783

Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

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A systematic approach to the analysis of protein phosphorylation

resolves10.1021/ac010081x

Phosphoprotein Isotope-Coded Affinity Tag Approach for Isolating and Quantitating Phosphopeptides in Proteome-Wide Analyses

resolves10.1016/S0167-7799(02)01944-3

Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome

resolves10.1136/jmg.39.10.705

Coffin-Lowry syndrome: clinical and molecular features

resolves10.1016/S0021-9258(19)67779-3

Purification and characterization of ribosomal protein S6 kinase I from Xenopus eggs.

resolves10.1212/WNL.56.2.207

Cognitive impairment in Coffin–Lowry syndrome correlates with reduced RSK2 activation

resolves10.1006/geno.1999.6004

A Novel Ribosomal S6-Kinase (RSK4; RPS6KA6) Is Commonly Deleted in Patients with Complex X-Linked Mental Retardation

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PDZ domains in synapse assembly and signalling

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Neurofibromatosis Type 1

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A mouse model for the learning and memory deficits associated with neurofibromatosis type I

resolves10.1038/nature711

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

resolves10.1016/S0896-6273(03)00645-7

The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1

resolves10.1038/36849

A role for the Ras signalling pathway in synaptic transmission and long-term memory

resolves10.1016/S0028-3908(01)00096-X

Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)

resolves10.1038/nrn1259

LTP: perils and progress

resolves10.1038/10154

Can molecules explain long-term potentiation?

resolves10.1016/S0092-8674(04)00115-1

Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory

The 3 references without a DOI — listed, not checked

no DOI — not checkedPearson, G. et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153–183 (2001).

no DOI — not checkedDownward, J. Control of Ras activation. Cancer Surv. 27, 87–100 (1996).

no DOI — not checkedThomas, G. M., Henderson, J. A., Rumbaugh, G. & Huganir, R. L. RSK2 binds and phosphorylates PDZ domain containing proteins. Soc. Neurosci. Abstr. 832.15 (2002).

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