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A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1

https://doi.org/10.1038/s41418-018-0116-5
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1 of 40 checkable references need attention · checked 2026-07-23

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

References needing attention

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Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats
The 39 checked references that resolve
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The Science of Stroke: Mechanisms in Search of Treatments
resolves10.1001/jamaneurol.2015.3886
Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke
resolves10.1161/STR.0b013e318284056a
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
resolves10.1161/STROKEAHA.108.531632
Apoptotic Mechanisms After Cerebral Ischemia
resolves10.1016/j.neuint.2013.06.004
Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons
resolves10.1016/j.tips.2007.12.003
Annexin A1 in the brain – undiscovered roles?
resolves10.1155/2016/8239258
Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance
resolves10.1016/j.bbadis.2017.04.001
Annexin A1 nuclear translocation induces retinal ganglion cell apoptosis after ischemia-reperfusion injury through the p65/IL-1β pathway
resolves10.1038/cdd.2016.19
Influenza A virus enhances its propagation through the modulation of Annexin-A1 dependent endosomal trafficking and apoptosis
resolves10.1016/j.tips.2010.04.001
Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia–reperfusion injury?
resolves10.1007/s12035-014-8781-y
Following OGD/R, Annexin 1 Nuclear Translocation and Subsequent Induction of Apoptosis in Neurons Are Assisted by Myosin IIA in a TRPM7 Kinase-Dependent Manner
resolves10.1038/cddis.2016.259
Nuclear translocation of annexin 1 following oxygen-glucose deprivation–reperfusion induces apoptosis by regulating Bid expression via p53 binding
resolves10.1021/cb2000296
Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β
resolves10.1126/scisignal.aaa0441
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser <sup>16</sup> to trigger its nuclear localization
resolves10.1038/nm996
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
resolves10.1016/j.tips.2017.01.003
Cell-Penetrating Peptides: From Basic Research to Clinics
resolves10.1016/S1474-4422(12)70225-9
Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial
resolves10.1089/jop.2014.0019
Subconjunctival Injection of XG-102, a c-Jun N-Terminal Kinase Inhibitor Peptide, in the Treatment of Endotoxin-Induced Uveitis in Rats
resolves10.1038/mt.2014.116
Induction of Androgen Formation in the Male by a TAT-VDAC1 Fusion Peptide Blocking 14-3-3ɛ Protein Adaptor and Mitochondrial VDAC1 Interactions
resolves10.1016/j.freeradbiomed.2016.06.009
Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults
resolves10.1042/CS20150415
Annexin A1 localization and its relevance to cancer
resolves10.1006/jmbi.2000.4423
X-ray structure of full-length annexin 1 and implications for membrane aggregation11Edited by D. Rees
resolves10.1242/jcs.166132
Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation
resolves10.1242/jcs.123042
Dynamic Trafficking of STAT5 Depends on an Unconventional Nuclear Localization Signal
resolves10.1042/BJ20150368
Nuclear localization signals for four distinct karyopherin-β nuclear import systems
resolves10.1016/j.cellsig.2015.01.013
Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis
resolves10.1016/j.bbrc.2016.08.093
Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway
resolves10.1016/j.bbrc.2017.03.130
Activation of Wnt3α/β-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation
resolves10.1038/cdd.2011.121
Fas death receptor signalling: roles of Bid and XIAP
resolves10.1038/sj.embor.7400892
Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies
resolves10.1016/j.peptides.2016.11.011
In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides
resolves10.1016/j.addr.2004.12.001
Tat peptide-mediated cellular delivery: back to basics
resolves10.1056/NEJMoa0804656
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
resolves10.1007/s12035-016-0173-z
Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke
resolves10.18632/oncotarget.11213
Doxorubicin-triggered self-assembly of native amphiphilic peptides into spherical nanoparticles
resolves10.1093/cercor/bhv096
A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau
The 6 references without a DOI — listed, not checked
no DOI — not checkedSong H, Kim W, Kim SH, Kim KT. VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity. Sci Rep. 2016;6:38452.
no DOI — not checkedYu H, Shi L, Qi G, Zhao S, Gao Y, Li Y. Gypenoside protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of mitogen-activated protein kinase mediated nuclear factor kappa B pathway in vitro and in vivo. Front Pharmacol. 2016;7:148.
no DOI — not checkedTeves LM, Cui H, Tymianski M. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2015;36:0271678X15612099.
no DOI — not checkedCook DJ, Teves L, Tymianski M. A translational paradigm for the preclinical evaluation of the stroke neuroprotectant Tat-NR2B9c in gyrencephalic nonhuman primates. Sci Transl Med. 2012;4:154ra133.
no DOI — not checkedRossi D, Gaidano G. Messengers of cell death: apoptotic signaling in health and disease. Haematologica. 2003;88:212–8.
no DOI — not checkedAnsari S, Azari H, Mcconnell DJ, Afzal A, Mocco J. Intraluminal middle cerebral artery occlusion (MCAO) model for ischemic stroke with laser doppler flowmetry guidance in mice. J Vis Exp. 2011;51:e2879–e2879.
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