Reference health

The art of using t-SNE for single-cell transcriptomics

https://doi.org/10.1038/s41467-019-13056-x
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46/46 checkable references clean · checked 2026-07-25

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 46 checked references that resolve
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Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain
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The single-cell transcriptional landscape of mammalian organogenesis
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UMAP: Uniform Manifold Approximation and Projection
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Dimensionality reduction for visualizing single-cell data using UMAP
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How to Use t-SNE Effectively
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Multi-scale similarities in stochastic neighbour embedding: Reducing dimensionality while preserving both local and global structure
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Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets
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Fast interpolation-based t-SNE for improved visualization of single-cell RNA-seq data
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viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
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Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types
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Application of t-SNE to human genetic data
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Revealing multi-scale population structure in large cohorts
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Stable Random Projection: Lightweight, General-Purpose Dimensionality Reduction for Digitized Libraries
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SCANPY: large-scale single-cell gene expression data analysis
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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
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Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
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Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics
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Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq
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scmap: projection of single-cell RNA-seq data across data sets
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Mapping the stereotyped behaviour of freely moving fruit flies
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Embedding to Reference t-SNE Space Addresses Batch Effects in Single-Cell Classification
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Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
resolves10.1137/18M1216134
Clustering with t-SNE, Provably
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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex
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Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling
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bigSCale: an analytical framework for big-scale single-cell data
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GPU accelerated t-distributed stochastic neighbor embedding
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Heavy-Tailed Kernels Reveal a Finer Cluster Structure in t-SNE Visualisations
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Generalizable and Scalable Visualization of Single-Cell Data Using Neural Networks
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Interpretable dimensionality reduction of single cell transcriptome data with deep generative models
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Hierarchical Stochastic Neighbor Embedding
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PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells
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M3Drop: dropout-based feature selection for scRNASeq
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openTSNE: a modular Python library for t-SNE dimensionality reduction and embedding
The 6 references without a DOI — listed, not checked
no DOI — not checkedvan der Maaten, L. & Hinton, G. Visualizing data using t-SNE. J. Mach. Learning Res. 9, 2579–2605 (2008).
no DOI — not checkedBodt, C. D., Mulders, D., Verleysen, M., & Lee, J. A. Perplexity-free t-SNE and twice student tt-SNE. In European Symposium on Artificial Neural Networks, Computational Intelligence and Machine Learning 123–128 (2018).
no DOI — not checkedvan der Maaten, L. Accelerating t-SNE using tree-based algorithms. J. Mach. Learning Res. 15, 3221–3245 (2014).
no DOI — not checkedLinderman, G. C., Rachh, M., Hoskins, J. G., Steinerberger, S. & Kluger, Y. Efficient algorithms for t-distributed stochastic neighborhood embedding. https://arxiv.org/abs/1712.09005 (2017).
no DOI — not checkedvan der Maaten, L. Learning a parametric embedding by preserving local structure. In Proceedings of the Twelth International Conference on Artificial Intelligence and Statistics 384–391 (2009).
no DOI — not checkedHinton, G. E. & Roweis, S.T. Stochastic neighbor embedding. In Advances in Neural Information Processing Systems 857–864 (2003).
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