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A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
50/50 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 50 checked references that resolve
resolves10.1073/pnas.0806993105
Making insulin-deficient type 1 diabetic rodents thrive without insulin
resolves10.1073/pnas.1008025107
Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
resolves10.2337/db10-0958
Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling
resolves10.1016/j.cmet.2013.08.004
Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin
resolves10.2337/db15-1160
Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release
resolves10.2337/db10-0426
Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
resolves10.7554/eLife.13828
Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist
resolves10.1038/nm.3579
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
resolves10.1007/s00125-016-3909-4
Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis
resolves10.1172/JCI82723
Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin
resolves10.3389/fendo.2020.588447
Leptin Receptors in RIP-Cre25Mgn Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice
resolves10.1210/en.2013-1328
Leptin Action in the Ventromedial Hypothalamic Nucleus Is Sufficient, But Not Necessary, to Normalize Diabetic Hyperglycemia
resolves10.1210/en.2014-1169
Role of Melanocortin Signaling in Neuroendocrine and Metabolic Actions of Leptin in Male Rats With Uncontrolled Diabetes
resolves10.2337/db08-1221
A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin
resolves10.1038/s41586-018-0049-7
Genetic identification of leptin neural circuits in energy and glucose homeostases
resolves10.1016/j.celrep.2014.04.010
Hypothalamic Agouti-Related Peptide Neurons and the Central Melanocortin System Are Crucial Mediators of Leptin’s Antidiabetic Actions
resolves10.1016/j.neuron.2011.05.028
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
resolves10.1016/j.molmet.2014.12.006
Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes
resolves10.1007/s00125-006-0473-3
Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity
resolves10.1523/JNEUROSCI.4816-09.2010
Leptin Excites Proopiomelanocortin Neurons via Activation of TRPC Channels
resolves10.1172/JCI59816
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
resolves10.1016/j.cmet.2016.04.013
Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control
resolves10.1523/JNEUROSCI.4861-12.2014
Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus
resolves10.1523/JNEUROSCI.3118-09.2010
Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons
resolves10.1016/j.celrep.2016.12.072
TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons
resolves10.1111/jne.12501
Insulin and leptin excite anorexigenic pro‐opiomelanocortin neurones via activation of <scp>TRPC</scp>5 channels
resolves10.1038/s42255-020-0229-2
Profound and redundant functions of arcuate neurons in obesity development
resolves10.15252/embr.201949210
Disrupted hypothalamic CRH neuron responsiveness contributes to diet‐induced obesity
resolves10.1038/s41467-020-17578-7
Paraventricular hypothalamus mediates diurnal rhythm of metabolism
resolves10.1126/science.1115524
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
resolves10.1038/nature02440
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
resolves10.1016/j.biocel.2016.09.027
Central leptin action on euglycemia restoration in type 1 diabetes: Restraining responses normally induced by fasting?
resolves10.1083/jcb.201803152
Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism
resolves10.1371/journal.pone.0031636
Glucose Enhances Leptin Signaling through Modulation of AMPK Activity
resolves10.1038/ncomms7618
Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons
resolves10.1172/JCI31516
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
resolves10.2337/dc16-1553
Efficacy and Safety of Metreleptin Therapy in Patients With Type 1 Diabetes: A Pilot Study
resolves10.1210/jcem.84.12.6184
Changes in Plasma Leptin during the Treatment of Diabetic Ketoacidosis
resolves10.1016/S0026-0495(98)90244-X
Plasma leptin in diabetic and insulin-treated diabetic and normal rats
resolves10.2337/db09-1918
Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
resolves10.1152/ajpendo.00253.2019
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia
resolves10.1038/srep19980
An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide Y
resolves10.1016/j.cmet.2013.11.003
Glutamate Mediates the Function of Melanocortin Receptor 4 on Sim1 Neurons in Body Weight Regulation
The 2 references without a DOI — listed, not checked
no DOI — not checkedHanaki, K., Becker, D. J. & Arslanian, S. A. Leptin before and after insulin therapy in children with new-onset type 1 diabetes. J. Clin. Endocrinol. Metab. 84, 1524–1526 (1999).
no DOI — not checkedHavel, P. J. et al. Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am. J. Physiol. 274, R1482–R1491 (1998).
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