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Clinical and therapeutic relevance of cancer-associated fibroblasts

https://doi.org/10.1038/s41571-021-00546-5
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Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

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The 153 checked references that resolve
resolves10.1016/j.ccr.2012.02.022
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
resolves10.1016/j.cell.2011.02.013
Hallmarks of Cancer: The Next Generation
resolves10.1038/nrc1094
Basement membranes: structure, assembly and role in tumour angiogenesis
resolves10.1016/j.biochi.2020.05.005
GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention research
resolves10.1016/j.yexcr.2010.02.045
Hallmarks of cancer: Interactions with the tumor stroma
resolves10.1038/nm.3394
Microenvironmental regulation of tumor progression and metastasis
resolves10.1152/physrev.1996.76.1.69
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction
resolves10.3389/fimmu.2019.01713
Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis
resolves10.1177/1947601911423940
The Role of Stromal Myofibroblast and Extracellular Matrix in Tumor Angiogenesis
resolves10.1038/nature01322
Inflammation and cancer
resolves10.1038/nrc.2016.73
The biology and function of fibroblasts in cancer
resolves10.1084/jem.20140692
Fibroblast heterogeneity in the cancer wound
resolves10.1038/s41568-019-0238-1
A framework for advancing our understanding of cancer-associated fibroblasts
resolves10.1158/1078-0432.CCR-18-1955
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression
resolves10.1158/2159-8290.CD-19-0094
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
resolves10.1038/s41422-019-0195-y
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
resolves10.1158/2159-8290.CD-19-0644
Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy
resolves10.1038/ng.3818
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
resolves10.1016/j.cell.2020.03.048
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer
resolves10.1016/j.cell.2017.10.044
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
resolves10.1038/s41467-018-07582-3
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
resolves10.1038/s43018-020-0082-y
Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome
resolves10.1158/2159-8290.CD-19-1384
Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer
resolves10.1016/j.ccell.2018.01.011
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
resolves10.1038/s41591-018-0096-5
Phenotype molding of stromal cells in the lung tumor microenvironment
resolves10.1016/j.celrep.2020.107628
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
resolves10.1073/pnas.1600363113
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
resolves10.1016/j.cell.2005.02.034
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
resolves10.1038/nature12783
Distinct fibroblast lineages determine dermal architecture in skin development and repair
resolves10.1016/S0016-5085(98)70209-4
Identification, culture, and characterization of pancreatic stellate cells in rats and humans
resolves10.1136/gut.44.4.534
Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis
resolves10.1172/JCI66369
Hepatic stellate cells in liver development, regeneration, and cancer
resolves10.1038/nature06188
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
resolves10.1158/0008-5472.CAN-08-0943
Carcinoma-Associated Fibroblast–Like Differentiation of Human Mesenchymal Stem Cells
resolves10.1016/j.ccr.2011.01.020
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
resolves10.1084/jem.20180818
Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer
resolves10.1158/0008-5472.CAN-07-3127
Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts
resolves10.1038/nm1613
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
resolves10.1158/0008-5472.CAN-13-0530
Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
resolves10.1056/NEJM198612253152606
Tumors: Wounds That Do Not Heal
resolves10.1073/pnas.91.19.9009
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.
resolves10.1074/jbc.M112.438846
Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
resolves10.1016/j.trecan.2016.05.004
Fibrosis and Cancer: Partners in Crime or Opposing Forces?
resolves10.1038/nrm2455
Cancer as an overhealing wound: an old hypothesis revisited
resolves10.4161/cbt.5.12.3354
Identification of fibroblast heterogeneity in the tumor microenvironment
resolves10.1111/cas.14537
Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine
resolves10.1152/physrev.00048.2019
Diversity and Biology of Cancer-Associated Fibroblasts
resolves10.1038/s41556-020-00613-6
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression
resolves10.1016/j.ccell.2021.03.012
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
resolves10.1016/j.ccell.2020.09.015
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer
resolves10.1016/j.ccell.2021.02.007
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
resolves10.1016/j.ccr.2014.04.005
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
resolves10.1084/jem.20162024
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
resolves10.3389/fimmu.2019.01835
The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
resolves10.4049/jimmunol.136.2.440
Antigen presentation by human dermal fibroblasts: activation of resting T lymphocytes.
resolves10.1126/science.7761853
Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs
resolves10.1038/s41467-018-03347-0
Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
resolves10.1038/s41590-020-0756-8
Fibroblasts as a source of self-antigens for central immune tolerance
resolves10.1038/s41467-018-03348-z
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
resolves10.1038/s41467-019-14134-w
Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
resolves10.1016/j.cell.2018.01.009
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
resolves10.1016/j.cell.2019.05.012
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
resolves10.1016/j.ccell.2020.06.005
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
resolves10.1158/2159-8290.CD-20-0775
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression
resolves10.1016/j.amjsurg.2007.05.004
Pancreatic cancer–associated stroma production
resolves10.1158/1535-7163.MCT-06-0686
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
resolves10.1158/1078-0432.CCR-11-3114
The Pancreas Cancer Microenvironment
resolves10.1053/j.gastro.2018.12.044
Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets
resolves10.1158/2159-8290.CD-18-0710
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma
resolves10.1038/s41586-019-1130-6
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
resolves10.1158/0008-5472.CAN-12-2066
Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
resolves10.1038/s41467-020-15188-x
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
resolves10.1038/s41467-019-12370-8
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
resolves10.1016/j.ccr.2005.10.012
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
resolves10.1016/j.ccr.2009.06.017
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
resolves10.1038/nature25501
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
resolves10.1038/nature25492
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
resolves10.1073/pnas.1109493108
VEGF-A and Tenascin-C produced by S100A4 <sup>+</sup> stromal cells are important for metastatic colonization
resolves10.1016/j.cell.2016.05.079
Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
resolves10.1126/science.1090922
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
resolves10.1016/j.cell.2004.12.018
PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells
resolves10.1016/S0092-8674(00)81009-0
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
resolves10.1016/j.ccell.2017.10.005
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
resolves10.1016/j.smim.2020.101417
Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies
resolves10.1007/BF00689637
Modulation of tumor cell response to chemotherapy by the organ environment
resolves10.1038/nm.1908
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
resolves10.1038/nrc2714
Environment-mediated drug resistance: a major contributor to minimal residual disease
resolves10.1038/s41467-019-10968-6
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
resolves10.1038/nrc1456
High interstitial fluid pressure — an obstacle in cancer therapy
resolves10.1038/ncb3021
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
resolves10.1073/pnas.1819889116
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy
resolves10.1126/science.1195300
Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α
resolves10.1073/pnas.1320318110
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
resolves10.1158/0008-5472.CAN-15-2973
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
resolves10.1038/nature19084
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
resolves10.1158/2159-8290.CD-19-0959
Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer
resolves10.1158/0008-5472.CAN-19-0960
Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance
resolves10.1158/2159-8290.CD-19-1353
Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment
resolves10.1016/j.cmet.2018.09.012
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
resolves10.1158/2159-8290.CD-18-1212
A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
resolves10.1016/j.cell.2015.08.016
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
resolves10.1038/ncomms16031
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
resolves10.1007/s00109-013-1020-6
Exosomes in tumor microenvironment influence cancer progression and metastasis
resolves10.1158/0008-5472.CAN-13-1791
Tumor–Stroma Interaction: Revealing Fibroblast-Secreted Exosomes as Potent Regulators of Wnt-Planar Cell Polarity Signaling in Cancer Metastasis
resolves10.1038/onc.2016.353
Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells
resolves10.1038/nrc1477
Friends or foes — bipolar effects of the tumour stroma in cancer
resolves10.1136/gutjnl-2015-309304
Stromal biology and therapy in pancreatic cancer: a changing paradigm
resolves10.1038/nm.4082
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
resolves10.1016/j.ccr.2014.04.021
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
resolves10.1016/j.ccr.2012.01.007
Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
resolves10.1126/science.1171362
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
resolves10.1073/pnas.1411679111
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
resolves10.1200/PO.17.00121
Stromal Content Is Correlated With Tissue Site, Contrast Retention, and Survival in Pancreatic Adenocarcinoma
resolves10.1016/j.ccell.2014.09.001
Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors
resolves10.1172/JCI146987
Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts
resolves10.1172/JCI136760
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix
resolves10.1158/1078-0432.CCR-03-0825
Type I Collagen Promotes the Malignant Phenotype of Pancreatic Ductal Adenocarcinoma
resolves10.1053/j.gastro.2004.12.036
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
resolves10.1016/j.cell.2009.10.027
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
resolves10.1016/j.ceb.2010.08.015
Dynamic interplay between the collagen scaffold and tumor evolution
resolves10.1200/JCO.2015.62.8719
Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
resolves10.1097/MPA.0000000000000458
A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma
resolves10.1634/theoncologist.2017-0024
A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma
resolves10.1634/theoncologist.2016-0479
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic <i>KRAS</i> Mutant Colorectal Adenocarcinoma
resolves10.1200/JCO.18.01295
Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313
resolves10.1200/JCO.20.00590
Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma
resolves10.1126/science.aan2507
A pathology atlas of the human cancer transcriptome
resolves10.1038/ng1013
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
resolves10.1056/NEJMoa071825
Breast-Cancer Stromal Cells with <i>TP53</i> Mutations and Nodal Metastases
resolves10.1016/j.ccell.2020.11.003
Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer
resolves10.1038/s41591-021-01323-8
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer
resolves10.1038/nmeth.3835
Monovar: single-nucleotide variant detection in single cells
resolves10.1126/science.aao4426
Aging and neurodegeneration are associated with increased mutations in single human neurons
resolves10.1038/s41586-019-1367-0
Somatic mutations and cell identity linked by Genotyping of Transcriptomes
resolves10.1073/pnas.1902510116
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
resolves10.1053/j.gastro.2011.06.047
Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression
resolves10.1016/j.cell.2014.08.007
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
resolves10.1038/s41576-018-0088-9
Challenges in unsupervised clustering of single-cell RNA-seq data
resolves10.1038/s41577-020-0306-5
A guide to cancer immunotherapy: from T cell basic science to clinical practice
resolves10.1038/nm.3646
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
resolves10.15252/emmm.201809085
Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program
resolves10.1016/j.stem.2021.01.007
A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting
resolves10.1158/0008-5472.CAN-10-3228
Podoplanin-Positive Fibroblasts Enhance Lung Adenocarcinoma Tumor Formation: Podoplanin in Fibroblast Functions for Tumor Progression
resolves10.1038/nm.3218
Origin and function of myofibroblasts in kidney fibrosis
resolves10.1002/dvg.20448
Efficient temporally‐controlled targeted mutagenesis in smooth muscle cells of the adult mouse
resolves10.1016/j.jcmgh.2020.05.004
Differential Contribution of Pancreatic Fibroblast Subsets to the Pancreatic Cancer Stroma
resolves10.1053/j.gastro.2020.11.011
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis
resolves10.1158/0008-5472.CAN-19-0454
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis
resolves10.1038/nm.2989
Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis
resolves10.1016/j.celrep.2020.107701
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
resolves10.1126/science.aba2374
Preventing <i>Engrailed-1</i> activation in fibroblasts yields wound regeneration without scarring
resolves10.1016/j.ccell.2015.03.008
Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
resolves10.1073/pnas.90.3.999
Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue.
The 10 references without a DOI — listed, not checked
no DOI — not checkedHosein, A. N. et al. Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution. JCI Insight 5, e129212 (2019).
no DOI — not checkedChen, Z. et al. Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma. Nat. Commun. 11, 5077 (2020).
no DOI — not checkedVirchow, R. Die cellularpathologie in ihrer begründung auf physiologische und pathologische gewebelehre. Zwanzig vorlesungen gehalten während der monate februar, märz und april 1858 im Pathologischen institute zu Berlin 440 (A. Hirschwald, 1858).
no DOI — not checkedTarin, D. & Croft, C. B. Ultrastructural features of wound healing in mouse skin. J. Anat. 105, 189–190 (1969).
no DOI — not checkedRonnov-Jessen, L. & Petersen, O. W. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab. Invest. 68, 696–707 (1993).
no DOI — not checkedWu, S. Z. et al. Stromal cell diversity associated with immune evasion in human triple-negative breast cancer. EMBO J. 39, e104063 (2020).
no DOI — not checkedHu, Y. et al. Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer. PLoS One 10, e0125625 (2015).
no DOI — not checkedZhao, H. et al. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife 5, e10250 (2016).
no DOI — not checkedMoinfar, F. et al. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 60, 2562–2566 (2000).
no DOI — not checkedChen, Y. et al. Podoplanin+tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biol. 16, e2005907 (2018).
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