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Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

https://doi.org/10.1038/s41598-017-01819-9
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75/75 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 75 checked references that resolve
resolves10.1007/s13365-014-0291-1
Eradication of human immunodeficiency virus from brain reservoirs
resolves10.1038/35073667
Pathways to neuronal injury and apoptosis in HIV-associated dementia
resolves10.1080/13550280600827369
Transcriptional activity of blood-and cerebrospinal fluid–derived<i>nef</i>/long-terminal repeat sequences isolated from a slow progressor infected with<i>nef</i>-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia
resolves10.3109/13550281003735709
Human immunodeficiency virus-1 evolutionary patterns associated with pathogenic processes in the brain
resolves10.1038/sj.gt.3302356
siRNA therapeutics: big potential from small RNAs
resolves10.1016/j.drudis.2006.10.013
Blood–brain barrier delivery
resolves10.1016/j.addr.2007.03.008
shRNA and siRNA delivery to the brain
resolves10.1016/j.addr.2016.06.011
Recent progress in development of siRNA delivery vehicles for cancer therapy
resolves10.1038/mt.2009.36
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
resolves10.1016/j.addr.2009.03.003
Lipid-based systemic delivery of siRNA
resolves10.1021/bm8009973
Internally Cationic Polyamidoamine PAMAM-OH Dendrimers for siRNA Delivery: Effect of the Degree of Quaternization and Cancer Targeting
resolves10.1039/b601381c
PAMAM dendrimers for efficient siRNA delivery and potent gene silencing
resolves10.1016/j.jconrel.2006.01.022
siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
resolves10.1021/nl9003865
Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery
resolves10.1073/pnas.92.16.7297
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
resolves10.1038/sj.gt.3302425
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
resolves10.1007/978-1-4939-3718-9_12
Cationic Lipid-Coated Polyplexes (Lipopolyplexes) for DNA and Small RNA Delivery
resolves10.1186/1745-6673-2-16
Nanotechnology-based drug delivery systems
resolves10.1002/jps.21924
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
resolves10.1089/hum.2008.023
Luciferin Detection After Intranasal Vector Delivery Is Improved by Intranasal Rather Than Intraperitoneal Luciferin Administration
resolves10.1016/j.exger.2010.08.026
Intranasal insulin as a therapeutic option in the treatment of cognitive impairments
resolves10.1523/JNEUROSCI.1350-09.2009
Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors
resolves10.1007/s13346-011-0050-2
Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice
resolves10.1089/rej.2009.0944
Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease
resolves10.1089/ars.2013.5371
An Overview of Autophagy: Morphology, Mechanism, and Regulation
resolves10.1128/JVI.02022-14
HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse
resolves10.1021/mp400541z
Long dsRNA-Mediated RNA Interference and Immunostimulation: A Targeted Delivery Approach Using Polyethyleneimine Based Nano-Carriers
resolves10.1523/JNEUROSCI.1398-04.2004
Activation of the cGMP Pathway in Dopaminergic Structures Reduces Cocaine-Induced EGR-1 Expression and Locomotor Activity
resolves10.1016/j.bbrc.2012.03.155
Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration
resolves10.1097/01.MLG.0000199741.08517.99
Breath Actuated Device Improves Delivery to Target Sites Beyond the Nasal Valve
resolves10.1021/bm015640o
Adsorption of Polyethyleneimine on Silver Nanoparticles and Its Interaction with a Plasmid DNA:  A Surface-Enhanced Raman Scattering Study
resolves10.1021/ac00217a012
Flow-injection analysis and real-time detection of RNA bases by surface-enhanced Raman spectroscopy
resolves10.3103/S1068335614110025
Local Raman spectroscopy of DNA
resolves10.1002/ana.410320304
Spectrum of human immunodeficiency virus–associated neocortical damage
resolves10.1212/WNL.43.11.2230
Clinical‐neuropathologic correlation in HIV‐associated dementia
resolves10.1159/000150539
HIV Dementia and the Basal Ganglia
resolves10.2165/00063030-200721010-00003
RNAi Therapy for HIV Infection
resolves10.1038/sj.gt.3302661
RNAi therapeutics: SNALPing siRNAs in vivo
resolves10.1016/j.cell.2008.06.034
T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice
resolves10.1038/mt.2009.271
RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice
resolves10.1126/scitranslmed.3001581
An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4 <sup>+</sup> T Cell Decline in Humanized Mice
resolves10.1038/nm725
siRNA-directed inhibition of HIV-1 infection
resolves10.1182/blood-2004-10-3959
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV
resolves10.1023/A:1011958726518
Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides
resolves10.1002/jgm.1006
siRNA delivery by a transferrin‐associated lipid‐based vector: a non‐viral strategy to mediate gene silencing
resolves10.1083/jcb.200903070
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
resolves10.1371/journal.pone.0005787
Differential Role of Autophagy in CD4 T Cells and Macrophages during X4 and R5 HIV-1 Infection
resolves10.1038/icb.2014.88
Roles of autophagy in HIV infection
resolves10.1084/jem.20150956
Therapeutic targeting of autophagy in neurodegenerative and infectious diseases
resolves10.1523/JNEUROSCI.0800-08.2008
Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
resolves10.1111/j.1750-3639.2011.00545.x
Autophagy in Dementias
resolves10.1155/2012/628978
Autophagy as a Therapeutic Target in Diabetic Nephropathy
resolves10.1038/nrneurol.2011.200
Control of autophagy as a therapy for neurodegenerative disease
resolves10.2533/chimia.1997.34
The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit
resolves10.1073/pnas.0804273106
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
resolves10.1016/j.ejps.2015.11.009
Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI
resolves10.3233/JAD-1998-1102
Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway
resolves10.1016/j.addr.2011.11.002
Intranasal delivery of biologics to the central nervous system
resolves10.1016/S0022-3565(24)39336-X
Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water Maze
resolves10.1385/JMN/31:02:165
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
resolves10.1038/nn0602-849
Sniffing neuropeptides: a transnasal approach to the human brain
resolves10.3109/10717549709051892
Olfactory Absorption of Insulin to the Brain
resolves10.1212/01.WNL.0000265401.62434.36
Intranasal insulin improves cognition and modulates β-amyloid in early AD
resolves10.1093/scan/nss062
Oxytocin enhances pupil dilation and sensitivity to ‘hidden’ emotional expressions
resolves10.1002/mds.26351
A randomized, double‐blind phase <scp>I</scp>/<scp>II</scp>a study of intranasal glutathione in <scp>P</scp>arkinson's disease
resolves10.1136/jmg.2008.062141
Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial
resolves10.2337/diabetes.48.3.557
Central nervous system effects of intranasally administered insulin during euglycemia in men.
resolves10.1016/j.psyneuen.2004.04.003
Intranasal insulin improves memory in humans
resolves10.1210/jc.2007-2606
Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin
resolves10.2337/db10-0329
Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
resolves10.1016/S0006-3223(03)00465-7
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
resolves10.1523/JNEUROSCI.3984-05.2005
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
resolves10.1002/ana.410230716
Distinct biological and serological properties of human immunodeficiency viruses from the brain
resolves10.1097/QAD.0b013e3283639804
A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-μ-opioid receptor interactions between human astroglia and microglia
resolves10.1097/QAD.0000000000000291
Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine
The 3 references without a DOI — listed, not checked
no DOI — not checkedEne, L., Duiculescu, D. & Ruta, S. M. How much do antiretroviral drugs penetrate into the central nervous system? Journal of medicine and life 4, 432–439 (2011).
no DOI — not checkedRodriguez, M. et al. Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood-Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro. Journal of neuroimmune pharmacology 10, 1–13 (2016).
no DOI — not checkedFehm, H. L. et al. The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans. The Journal of clinical endocrinology and metabolism 86, 1144–1148 (2001).
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