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The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel

https://doi.org/10.1038/srep43487
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30/30 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 30 checked references that resolve
resolves10.1146/annurev-virology-100114-054846
Pathophysiological Consequences of Calcium-Conducting Viroporins
resolves10.3390/v7102880
Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?
resolves10.1099/vir.0.000201
Viroporins: structure, function and potential as antiviral targets
resolves10.1007/978-3-319-20149-8_7
Viroporins
resolves10.1093/cid/civ1013
Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000–2013
resolves10.1073/pnas.1216539109
Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-β signaling is required for rotavirus replication
resolves10.1128/JVI.01124-07
The Formation of Viroplasm-Like Structures by the Rotavirus NSP5 Protein Is Calcium Regulated and Directed by a C-Terminal Helical Domain
resolves10.1016/B978-0-12-802241-2.00008-0
Pleiotropic Properties of Rotavirus Nonstructural Protein 4 (NSP4) and Their Effects on Viral Replication and Pathogenesis
resolves10.1128/JVI.02629-13
Activation of the Endoplasmic Reticulum Calcium Sensor STIM1 and Store-Operated Calcium Entry by Rotavirus Requires NSP4 Viroporin Activity
resolves10.1016/S0006-3495(89)82710-9
Modified reconstitution method used in patch-clamp studies of Escherichia coli ion channels
resolves10.1016/j.febslet.2008.12.033
Rapid and improved reconstitution of bacterial mechanosensitive ion channel proteins MscS and MscL into liposomes using a modified sucrose method
resolves10.1128/mBio.00265-10
Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity
resolves10.1016/j.virol.2007.11.021
Epitope mapping and use of epitope-specific antisera to characterize the VP5⁎ binding site in rotavirus SA11 NSP4
resolves10.1085/jgp.109.4.449
Ion-dependent Inactivation of Barium Current through L-type Calcium Channels
resolves10.1146/annurev.cb.06.110190.003435
Calcium Channels, Stores, and Oscillations
resolves10.1371/journal.pone.0011112
The Proapoptotic Influenza A Virus Protein PB1-F2 Forms a Nonselective Ion Channel
resolves10.1128/jvi.69.9.5763-5772.1995
The rotavirus nonstructural glycoprotein NSP4 mobilizes Ca2+ from the endoplasmic reticulum
resolves10.1128/JVI.06759-11
Genetic Divergence of Rotavirus Nonstructural Protein 4 Results in Distinct Serogroup-Specific Viroporin Activity and Intracellular Punctate Structure Morphologies
resolves10.1038/nrmicro2820
Viroporins: structure and biological functions
resolves10.1128/JVI.05421-11
Membrane Integration of Poliovirus 2B Viroporin
resolves10.1016/S0014-5793(03)01453-4
Cation‐selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride
resolves10.1128/JVI.02227-14
Structural Plasticity of the Coiled-Coil Domain of Rotavirus NSP4
resolves10.1128/JVI.00349-11
Novel Pentameric Structure of the Diarrhea-Inducing Region of the Rotavirus Enterotoxigenic Protein NSP4
resolves10.1016/0092-8674(92)90452-I
Influenza virus M2 protein has ion channel activity
resolves10.1128/JVI.00521-09
Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro
resolves10.2165/00148581-200608060-00004
A Review of Calcium Channel Antagonists in the Treatment of Pediatric Hypertension
resolves10.1006/viro.1998.9433
Oncosis in MA104 Cells Is Induced by Rotavirus Infection through an Increase in Intracellular Ca2+Concentration
resolves10.1136/gutjnl-2013-305663
Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice
resolves10.1371/journal.pone.0159660
Rotavirus and Serotonin Cross-Talk in Diarrhoea
resolves10.1016/j.virol.2015.08.010
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome
The 1 reference without a DOI — listed, not checked
no DOI — not checkedHille, B. Ion Channels of Excitable Membranes(Sinauer Associates, Inc., Sunderland, MA, 2001).
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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