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Peptide macrocyclization by transition metal catalysis
1 of 143 checkable references need attention · checked 2026-07-22
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References needing attention
does not resolve to a known work10.1007/BF02442590
The 142 checked references that resolve
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Peptide stapling techniques based on different macrocyclisation chemistries
resolves10.1038/nrd2590
The exploration of macrocycles for drug discovery — an underexploited structural class
resolves10.1021/cb300515u
Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints
resolves10.1039/C4SC03089C
Macrocycles: lessons from the distant past, recent developments, and future directions
resolves10.1002/adtp.201800052
Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future
resolves10.1016/j.cbpa.2018.03.019
Peptide modification and cyclization via transition-metal catalysis
resolves10.1002/anie.201806250
Late‐Stage Peptide Diversification by Position‐Selective C−H Activation
resolves10.1038/nchem.2393
Site-selective protein-modification chemistry for basic biology and drug development
resolves10.1021/acs.chemrev.8b00744
Multicomponent Reaction Toolbox for Peptide Macrocyclization and Stapling
resolves10.1111/j.1399-3011.2004.00199.x
Cyclization of several linear penta‐ and heptapeptides with different metal ions studied by CD spectroscopy<sup>*</sup>
resolves10.1002/anie.201610801
One‐Pot Assembly of Amino Acid Bridged Hybrid Macromulticyclic Cages through Multiple Multicomponent Macrocyclizations
resolves10.1021/acs.chemrev.5b00056
Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization
resolves10.1021/jo00032a028
Model studies on the synthesis of carboxylate-binding pocket analogs of vancomycin using arene-ruthenium chemistry
resolves10.1021/jo960435y
Cycloetherification Reactions of Areneruthenium Complexes: Construction of a 16-Membered Cyclic Peptide Model for Teicoplanin
resolves10.1021/ja970614c
Total Synthesis of the Cyclic Biphenyl Ether Peptides K-13 and OF4949-III <i>via</i> S<sub>N</sub>Ar Macrocyclization of Peptidyl Ruthenium π-Arene Complexes
resolves10.1021/ol991084n
Novel Cyclic Tripeptides and Substituted Aromatic Amino Acids via Ruthenium-Activated S<sub>N</sub>Ar Reactions
resolves10.1002/pep2.24049
Decarboxylative couplings as versatile tools for late‐stage peptide modifications
resolves10.1021/cr500431s
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
resolves10.3390/catal7030074
The Suzuki–Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization
resolves10.3762/bjoc.15.72
Solid-phase synthesis of biaryl bicyclic peptides containing a 3-aryltyrosine or a 4-arylphenylalanine moiety
resolves10.1021/jo026693e
Solid-Phase Synthesis of an A−B Loop Mimetic of the Cε3 Domain of Human IgE: Macrocyclization by Sonogashira Coupling
resolves10.1021/jo051412z
Synthesis of Conformationally Constrained Cyclic Peptides Using an Intramolecular Sonogashira Coupling
resolves10.1039/C8CC06871B
A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives
resolves10.1021/ja00151a029
Palladium-Mediated Macrocyclization on Solid Support and Its Applications to Combinatorial Synthesis
resolves10.1016/S0040-4039(02)02573-X
Synthesis of small cyclic peptides via intramolecular Heck reactions
resolves10.1021/jo061366i
Synthesis of Cyclic Peptides Constrained with Biarylamine Linkers Using Buchwald−Hartwig C−N Coupling
resolves10.1021/acs.orglett.6b01961
Synthesis of Cyclic Peptidomimetics via a Pd-Catalyzed Macroamination Reaction
resolves10.1021/jo9018792
Application of Negishi Cross-Coupling to the Synthesis of the Cyclic Tripeptides OF4949-III and K-13
resolves10.1021/acsmedchemlett.9b00036
Development of a Platform To Enable Efficient Permeability Evaluation of Novel Organo-Peptide Macrocycles
resolves10.1039/C8CS00201K
A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry
resolves10.1021/ja710731a
Room Temperature and Phosphine Free Palladium Catalyzed Direct C-2 Arylation of Indoles
resolves10.1002/chem.200902676
Postsynthetic Modification of Peptides: Chemoselective C‐Arylation of Tryptophan Residues
resolves10.1039/c2cc36962a
Peptidic macrocyclization via palladium-catalyzed chemoselective indole C-2 arylation
resolves10.1038/ncomms8160
New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues
resolves10.1002/chem.201601832
Constrained Cyclopeptides: Biaryl Formation through Pd‐Catalyzed C−H Activation in Peptides—Structural Control of the Cyclization vs. Cyclodimerization Outcome
resolves10.1002/anie.201807953
Backbone‐Enabled Directional Peptide Macrocyclization through Late‐Stage Palladium‐Catalyzed δ‐C(sp<sup>2</sup>)−H Olefination
resolves10.1038/s41467-018-05440-w
Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
resolves10.1126/sciadv.aaw0323
Macrocyclization of peptidoarylacetamides with self-assembly properties through late-stage palladium-catalyzed C(sp
<sup>2</sup>
)▬H olefination
resolves10.1021/cr100280d
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
resolves10.1021/acs.orglett.9b00987
Pd-Catalyzed Site-Selective C(sp<sup>2</sup>)–H Olefination and Alkynylation of Phenylalanine Residues in Peptides
resolves10.1021/ja510233h
Site-Selective C(sp<sup>3</sup>)–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus
resolves10.1002/anie.201706367
Palladium(II)‐Catalyzed Site‐Selective C(sp<sup>3</sup>)−H Alkynylation of Oligopeptides: A Linchpin Approach for Oligopeptide–Drug Conjugation
resolves10.1039/C6SC05530C
Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp
<sup>3</sup>
)–H activation
resolves10.1038/s41557-018-0006-y
A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation
resolves10.1073/pnas.1311706110
Template-constrained macrocyclic peptides prepared from native, unprotected precursors
resolves10.1039/c0sc00234h
Catalytic asymmetric allylic alkylation employing heteroatom nucleophiles: a powerful method for C–X bond formation
resolves10.1021/ja00534a029
Allylic alkylation. Palladium-catalyzed substitutions of allylic carboxylates. Stereo- and regiochemistry
resolves10.1021/ja00203a042
Palladium-catalyzed synthesis of macrocycles. A total synthesis of (-)-aspochalasin B
resolves10.1021/ja102304p
Total Synthesis of Complestatin: Development of a Pd(0)-Mediated Indole Annulation for Macrocyclization
resolves10.1021/ja00017a059
Synthesis of indoles via palladium-catalyzed heteroannulation of internal alkynes
resolves10.1002/anie.201807536
Metal‐Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold
resolves10.1021/acs.orglett.7b01911
Water-Soluble Palladium Reagents for Cysteine <i>S</i>-Arylation under Ambient Aqueous Conditions
resolves10.1039/C6SC05454D
Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation
resolves10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
resolves10.1021/jo011148j
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
resolves10.1021/ol0518028
Efficient Route to<i>C</i><sub>2</sub>Symmetric Heterocyclic Backbone Modified Cyclic Peptides
resolves10.1002/anie.200461656
Head‐to‐Tail Peptide Cyclodimerization by Copper‐Catalyzed Azide–Alkyne Cycloaddition
resolves10.1021/ol053095o
Click Chemistry as a Route to Cyclic Tetrapeptide Analogues: Synthesis of<i>c</i><i>yclo</i>-[Pro-Val-ψ(triazole)-Pro-Tyr]
resolves10.1021/ol702228u
Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides
resolves10.1002/anie.200805901
Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three‐Dimensional Scaffolds for Rational Drug Design: Receptor‐Selective Somatostatin Analogues
resolves10.1021/ol303572t
Efficient Construction of Proline-Containing β-Turn Mimetic Cyclic Tetrapeptides via CuAAC Macrocyclization
resolves10.1021/jo800142s
Synthesis and Conformational Analysis of a Cyclic Peptide Obtained via <i>i</i> to <i>i</i>+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition
resolves10.1002/ejoc.200901157
Cu<sup>I</sup>‐Catalyzed Azide–Alkyne Intramolecular <i>i</i>‐to‐(<i>i</i>+4) Side‐Chain‐to‐Side‐Chain Cyclization Promotes the Formation of Helix‐Like Secondary Structures
resolves10.1021/jm201125d
Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction
resolves10.1016/j.tet.2013.10.032
The CuI-catalyzed alkyne–azide cycloaddition as direct conjugation/cyclization method of peptides to steroids
resolves10.1002/anie.201005846
Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics
resolves10.1039/C4SC00045E
Functionalised staple linkages for modulating the cellular activity of stapled peptides
resolves10.1002/anie.201508416
Double Strain‐Promoted Macrocyclization for the Rapid Selection of Cell‐Active Stapled Peptides
resolves10.1021/jo402670d
Cu(I)-Catalyzed Synthesis of Dihydropyrimidin-4-ones toward the Preparation of β- and β<sup>3</sup>-Amino Acid Analogues
resolves10.1002/asia.201700339
Copper(I)‐Mediated Denitrogenative Macrocyclization for the Synthesis of Cyclic α<sub>3</sub>β‐Tetrapeptide Analogues
resolves10.1002/anie.201611685
Diversity‐Oriented Synthesis of Cyclic Azapeptides by A<sup>3</sup>‐Macrocyclization Provides High‐Affinity CD36‐Modulating Peptidomimetics
resolves10.1002/anie.201705065
Adapting the Glaser Reaction for Bioconjugation: Robust Access to Structurally Simple, Rigid Linkers
resolves10.1039/jr9590000889
182. Macrocyclic acetylenic compounds. Part I. Cyclotetradeca-1 :3-diyne and related compounds
resolves10.1016/j.bmc.2014.10.026
Glaser oxidative coupling on peptides: Stabilization of β-turn structure via a 1,3-butadiyne constraint
resolves10.1039/C5OB01153A
Oxidative α,ω-diyne coupling as an approach towards novel peptidic macrocycles
resolves10.1002/ejoc.201201159
The Glaser–Hay Reaction: Optimization and Scope Based on <sup>13</sup>C NMR Kinetics Experiments
resolves10.1021/jacs.7b11853
Mechanism of the Ullmann Biaryl Ether Synthesis Catalyzed by Complexes of Anionic Ligands: Evidence for the Reaction of Iodoarenes with Ligated Anionic Cu<sup>I</sup> Intermediates
resolves10.1002/anie.200503538
Mild Ullmann‐Type Biaryl Ether Formation Reaction by Combination of <i>ortho</i>‐Substituent and Ligand Effects
resolves10.1021/ja000563a
An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides
resolves10.1002/(SICI)1521-3773(19981217)37:23<3281::AID-ANIE3281>3.0.CO;2-V
Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis
resolves10.1021/ol0508781
Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z
resolves10.1021/jo051933m
Synthesis of Alkyne-Bridged Cyclic Tripeptides toward Constrained Mimics of Vancomycin
resolves10.1038/ncomms11300
Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides
resolves10.1002/chem.201604621
Synergistic Heterobimetallic Manifold for Expedient Manganese(I)‐Catalyzed C−H Cyanation
resolves10.1002/anie.201702193
Air‐Stable Manganese(I)‐Catalyzed C−H Activation for Decarboxylative C−H/C−O Cleavages in Water
resolves10.1002/anie.201812705
Late‐Stage Diversification through Manganese‐Catalyzed C−H Activation: Access to Acyclic, Hybrid, and Stapled Peptides
resolves10.1002/anie.201611118
Manganese‐Catalyzed C−H Alkynylation: Expedient Peptide Synthesis and Modification
resolves10.1039/C9SC00694J
Photoredox Ni-catalyzed peptide C(sp
<sup>2</sup>
)–O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization
resolves10.1038/nchem.2888
Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials
resolves10.1021/ja505964r
Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin
resolves10.1002/anie.201609662
Nickel‐Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms
resolves10.1351/pac198658050675
Invention of new reactions useful in the chemistry of natural products
resolves10.1002/anie.201900243
Rapid, Traceless, Ag
<sup>I</sup>
‐Promoted Macrocyclization of Peptides Possessing an N‐Terminal Thioamide
resolves10.1002/ejoc.201800298
Recent Advances in [Cp*M<sup>III</sup>] (M = Co, Rh, Ir)‐Catalyzed Intramolecular Annulation Through C–H Activation
resolves10.1021/acs.orglett.7b01051
Rhodium(III)-Catalyzed C–H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones
resolves10.1002/chem.201602332
Harnessing C−H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones
resolves10.1016/j.chempr.2018.07.004
Gold-Catalyzed Oxidative Coupling of Alkynes toward the Synthesis of Cyclic Conjugated Diynes
resolves10.1021/acs.orglett.8b02858
Macrolactonization of Alkynyl Alcohol through Rh(I)/Yb(III) Catalysis
The 1 reference without a DOI — listed, not checked
no DOI — not checkedS. Zaretsky and A. K.Yudin , Practical Medicinal Chemistry with Macrocycles: Design, Synthesis, and Case Studies , ed. E. Marsault and M. L. Peterson , John Wiley & Sons , Hoboken, New Jersey , 2017 , pp. 1–24
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