Every reference with a DOI in the deposited reference list resolved to a known
work in Crossref or DataCite at the dated check, and none carried a retraction,
withdrawal, or removal notice.
The 111 checked references that resolve
resolves10.1038/nrd.2016.29Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
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resolves10.1016/S0092-8674(00)81307-0Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
resolves10.1016/S0092-8674(00)81717-1The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
resolves10.1038/nchembio.2153Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices
resolves10.1073/pnas.1303002110Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
resolves10.1021/jm4011675Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress
resolves10.1021/cb501020rHydrocarbon Stapled Peptides as Modulators of Biological Function
resolves10.1021/ja405108pIn Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide
resolves10.1021/acschembio.6b00486Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein–Protein Interaction
resolves10.1038/nrd1343Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
resolves10.1038/nbt1127Engineering novel binding proteins from nonimmunoglobulin domains
resolves10.1021/jm1012374Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery
resolves10.1038/nrd2590The exploration of macrocycles for drug discovery — an underexploited structural class
resolves10.1021/np200906sNatural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
resolves10.1126/science.4001944Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface
resolves10.1002/pmic.200500606T7 lytic phage‐displayed peptide libraries exhibit less sequence bias than M13 filamentous phage‐displayed peptide libraries
resolves10.1016/j.jviromet.2006.09.017Bacteriophage T4 nanoparticle capsid surface SOC and HOC bipartite display with enhanced classical swine fever virus immunogenicity: A powerful immunological approach
resolves10.1038/nchembio.184Phage-encoded combinatorial chemical libraries based on bicyclic peptides
resolves10.1016/j.tetlet.2008.11.094Thiol-ene reactions of 1,3,5-triacryloylhexahydro-1,3,5-triazine (TAT): facile access to functional tripodal thioethers
resolves10.1002/cbic.201200049Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides
resolves10.1039/c4cc00811aConstruction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7
resolves10.1021/cb4006722Discovery of Light-Responsive Ligands through Screening of a Light-Responsive Genetically Encoded Library
resolves10.1021/ja301017y<i>In Vitro</i>
Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors
resolves10.1021/ja054373hA General Route for Post-Translational Cyclization of mRNA Display Libraries
resolves10.1039/c2ob25306bSelective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation
resolves10.1016/j.chembiol.2011.09.013Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library
resolves10.1126/science.2146742Protein Splicing Converts the Yeast
<i>TFP1</i>
Gene Product to the 69-kdDSubunit of the Vacuolar H
<sup>+</sup>
-Adenosine Triphosphatase
resolves10.1073/pnas.95.16.9226Protein
<i>trans</i>
-splicing by a split intein encoded in a split DnaE gene of
<i>Synechocystis</i>
sp. PCC6803
resolves10.1073/pnas.93.19.10315Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.
resolves10.1073/pnas.0406999101A systematic method for identifying small-molecule modulators of protein–protein interactions
resolves10.1002/anie.200500417Genetically Selected Cyclic‐Peptide Inhibitors of AICAR Transformylase Homodimerization
resolves10.1074/jbc.M206162200Retrovirally Delivered Random Cyclic Peptide Libraries Yield Inhibitors of Interleukin-4 Signaling in Human B Cells
resolves10.1021/ja402993uA Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells
resolves10.1039/c3sc50481fA cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
resolves10.1021/jm501892gThe Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity
resolves10.1073/pnas.0805130105High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
resolves10.1021/jm0606600Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor
resolves10.1021/jm2007062Optimization of the Potency and Pharmacokinetic Properties of a Macrocyclic Ghrelin Receptor Agonist (Part I): Development of Ulimorelin (TZP-101) from Hit to Clinic
resolves10.1016/j.bmcl.2009.09.089Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog
resolves10.1038/nchem.1729A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling
resolves10.1055/s-0035-1561414Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology
resolves10.1038/354082a0A new type of synthetic peptide library for identifying ligand-binding activity
resolves10.1038/354084a0Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
resolves10.1021/ja063722kHigh-Throughput Sequence Determination of Cyclic Peptide Library Members by Partial Edman Degradation/Mass Spectrometry
resolves10.1021/cc000102lRapid Sequencing of Library-Derived Peptides by Partial Edman Degradation and Mass Spectrometry
resolves10.1021/cb200450wCyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction
resolves10.1021/ja405106uScreening Bicyclic Peptide Libraries for Protein–Protein Interaction Inhibitors: Discovery of a Tumor Necrosis Factor-α Antagonist
resolves10.1002/anie.201502763Inhibition of Ras Signaling by Blocking Ras–Effector Interactions with Cyclic Peptides
resolves10.1016/S0169-409X(00)00129-0Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
resolves10.1002/bdd.476The effect of increased lipoprotein levels on the pharmacokinetics of cyclosporine A in the laboratory rat
resolves10.1021/acs.jmedchem.5b00919Going Out on a Limb: Delineating The Effects of β-Branching, <i>N</i>-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues
resolves10.1021/ja303200dIntestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified
resolves10.1021/acs.jcim.6b00251Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States
resolves10.4155/fmc.15.78Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products
resolves10.1021/jm070836dEffect of Structural and Conformation Modifications, Including Backbone Cyclization, of Hydrophilic Hexapeptides on Their Intestinal Permeability and Enzymatic Stability
resolves10.1016/j.bmc.2014.11.034Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties
resolves10.1021/ml500239mEPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides
resolves10.1038/nchembio.664On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
resolves10.1039/C5MB00308CSynthesis of a large library of macrocyclic peptides containing multiple and diverse
<i>N</i>
-alkylated residues
resolves10.1021/cc700185gCyclic Peptidyl Inhibitors of Grb2 and Tensin SH2 Domains Identified from Combinatorial Libraries
resolves10.1038/mt.2012.132Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication
resolves10.1021/ja510391nFluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides
resolves10.1021/jm901778vMembrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1
resolves10.1038/ncomms1459Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides
resolves10.1002/anie.201102572Cell‐Penetrating Homochiral Cyclic Peptides as Nuclear‐Targeting Molecular Transporters
resolves10.1021/bi5004102Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery
resolves10.1021/cb3005275Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs
resolves10.1021/ja503710nCell-Permeable Bicyclic Peptide Inhibitors against Intracellular Proteins
resolves10.1021/acscombsci.5b00164Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
resolves10.1002/anie.201411594Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity
resolves10.1002/anie.201610888Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization
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