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First FDA Approval Agnostic of Cancer Site — When a Biomarker Defines the Indication

https://doi.org/10.1056/nejmp1709968
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5/5 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 5 checked references that resolve
resolves10.1158/1078-0432.CCR-15-1678
Microsatellite Instability as a Biomarker for PD-1 Blockade
resolves10.1038/nm.4191
Classification and characterization of microsatellite instability across 18 cancer types
resolves10.1158/1078-0432.CCR-14-0332
Mismatch Repair Status and <i>BRAF</i> Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
resolves10.1200/JCO.2015.63.2497
Phase II Pilot Study of Vemurafenib in Patients With Metastatic <i>BRAF</i> -Mutated Colorectal Cancer
resolves10.1158/1538-7445.SABCS16-PD2-08
Abstract PD2-08: Neratinib + fulvestrant in <i>ERBB2</i>-mutant, HER2–non-amplified, estrogen receptor (ER)-positive, metastatic breast cancer (MBC): Preliminary analysis from the phase II SUMMIT trial
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