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Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)
48/48 checkable references clean · checked 2026-07-25
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
The 48 checked references that resolve
resolves10.1016/j.bbapap.2008.02.010
Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates
resolves10.1080/10409230701380452
Protein Degradation within Mitochondria: Versatile Activities of AAA Proteases and Other Peptidases
resolves10.1016/j.resmic.2004.06.003
Comparative genomics and functional roles of the ATP-dependent proteases Lon and Clp during cytosolic protein degradation
resolves10.1016/S1016-8478(23)25247-4
Oligomeric Structure of the ATP-dependent Protease La (Lon) of Escherichia coli
resolves10.1073/pnas.96.12.6787
Mitochondrial Lon of
<i>Saccharomyces cerevisiae</i>
is a ring-shaped protease with seven flexible subunits
resolves10.1016/j.resmic.2009.08.003
Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases
resolves10.1210/me.2005-0458
Turnover of Mitochondrial Steroidogenic Acute Regulatory (StAR) Protein by Lon Protease: The Unexpected Effect of Proteasome Inhibitors
resolves10.1016/j.cell.2007.01.047
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
resolves10.1074/jbc.M502796200
Cleavage Site Selection within a Folded Substrate by the ATP-dependent Lon Protease
resolves10.1038/ncb836
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
resolves10.1016/S0378-1119(03)00403-7
The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals
resolves10.1021/bi970928c
The Human LON Protease Binds to Mitochondrial Promoters in a Single-Stranded, Site-Specific, Strand-Specific Manner
resolves10.1074/jbc.M309642200
DNA and RNA Binding by the Mitochondrial Lon Protease Is Regulated by Nucleotide and Protein Substrate
resolves10.1074/jbc.M611540200
Roles for the Human ATP-dependent Lon Protease in Mitochondrial DNA Maintenance
resolves10.1016/S0021-9258(17)42340-4
PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae.
resolves10.1126/science.8146662
Requirement for the Yeast Gene
<i>LON</i>
in Intramitochondrial Proteolysis and Maintenance of Respiration
resolves10.1093/jb/mvi169
PDIP38 Associates with Proteins Constituting the Mitochondrial DNA Nucleoid
resolves10.1093/nar/gkp157
Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A
resolves10.1128/MCB.24.22.9823-9834.2004
Architectural Role of Mitochondrial Transcription Factor A in Maintenance of Human Mitochondrial DNA
resolves10.1074/jbc.M303842200
Functional Domains of Chicken Mitochondrial Transcription Factor A for the Maintenance of Mitochondrial DNA Copy Number in Lymphoma Cell Line DT40
resolves10.1038/ng909
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
resolves10.1042/bj3540243
Drosophila mitochondrial transcription factor A (d-TFAM) is dispensable for the transcription of mitochondrial DNA in Kc167 cells
resolves10.1038/ng0398-231
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
resolves10.1093/nar/30.9.1929
Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells
resolves10.1074/jbc.M610550200
Differential Phenotypes of Active Site and Human Autosomal Dominant Progressive External Ophthalmoplegia Mutations in Drosophila Mitochondrial DNA Helicase Expressed in Schneider Cells
resolves10.1007/978-1-59745-365-3_15
Functional Analysis by Inducible RNA Interference in Drosophila melanogaster
resolves10.1074/jbc.M500569200
Drosophila Mitochondrial Transcription Factor B1 Modulates Mitochondrial Translation but Not Transcription or DNA Copy Number in Schneider Cells
resolves10.1074/jbc.M401643200
Drosophila Mitochondrial Transcription Factor B2 Regulates Mitochondrial DNA Copy Number and Transcription in Schneider Cells
resolves10.1093/nar/gkl703
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells
resolves10.1196/annals.1404.015
Importance of the Lon Protease in Mitochondrial Maintenance and the Significance of Declining Lon in Aging
resolves10.1016/j.freeradbiomed.2004.11.017
Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death
resolves10.1016/j.febslet.2007.04.076
ClpP: A distinctive family of cylindrical energy‐dependent serine proteases
resolves10.1186/1471-2121-6-28
Dynamic assembly, localization and proteolysis of the Bacillus subtilis SMC complex
resolves10.1073/pnas.0910392106
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine
resolves10.1074/jbc.M803674200
Physiological and Biochemical Defects in Carboxyl-terminal Mutants of Mitochondrial DNA Helicase
resolves10.1074/jbc.274.21.14779
Functional Interactions of Mitochondrial DNA Polymerase and Single-stranded DNA-binding Protein
resolves10.1074/jbc.272.21.13640
Accessory Subunit of Mitochondrial DNA Polymerase fromDrosophila Embryos
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