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POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation

https://doi.org/10.1073/pnas.1715165115
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73/73 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 73 checked references that resolve
resolves10.1101/gad.1536007
Hippo signaling in organ size control
resolves10.1111/dgd.12212
Roles of <scp>H</scp>ippo signaling pathway in size control of organ regeneration
resolves10.15252/embr.201438638
The Hippo signaling pathway in stem cell biology and cancer
resolves10.1016/S0092-8674(03)00557-9
The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis
resolves10.1038/ncb1051
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
resolves10.1038/ncb1050
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
resolves10.1016/S0092-8674(03)00549-X
hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts
resolves10.1101/gad.9.5.534
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
resolves10.1242/dev.121.4.1053
Identifying tumor suppressors in genetic mosaics: the <i>Drosophila lats</i> gene encodes a putative protein kinase
resolves10.1016/j.cell.2005.06.007
The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP
resolves10.1242/dev.015255
In vivo regulation of Yorkie phosphorylation and localization
resolves10.1002/dvdy.22723
Hippo signaling in <i>Drosophila</i>: Recent advances and insights
resolves10.1101/gad.274027.115
Mechanisms of Hippo pathway regulation
resolves10.1038/ncb1339
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
resolves10.1016/j.devcel.2009.12.012
Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded
resolves10.1016/j.devcel.2009.12.013
The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
resolves10.1016/j.devcel.2009.12.011
Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
resolves10.1126/scisignal.2004208
Hippo Gains Weight: Added Insights and Complexity to Pathway Control
resolves10.1016/j.devcel.2017.02.004
Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded
resolves10.1093/emboj/cdg021
POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis
resolves10.1128/MCB.25.22.9949-9959.2005
Regulation of Apoptotic c-Jun N-Terminal Kinase Signaling by a Stabilization-Based Feed-Forward Loop
resolves10.1016/j.febslet.2006.05.005
POSH, a scaffold protein for JNK signaling, binds to ALG‐2 and ALIX in <i>Drosophila</i>
resolves10.1074/jbc.M601056200
Direct Interaction of the Molecular Scaffolds POSH and JIP Is Required for Apoptotic Activation of JNKs
resolves10.1038/sj.embor.7400537
The RING‐finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila
resolves10.1016/j.cellsig.2005.05.026
Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes
resolves10.1083/jcb.200611036
The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp
resolves10.1016/j.celrep.2012.08.007
POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration
resolves10.1083/jcb.201404066
Rab8, POSH, and TAK1 regulate synaptic growth in a <i>Drosophila</i> model of frontotemporal dementia
resolves10.1002/eji.201343635
The <scp>POSH</scp>/<scp>JIP</scp>‐1 scaffold network regulates <scp>TCR</scp>‐mediated <scp>JNK</scp>1 signals and effector function in <scp>CD</scp>8<sup>+</sup><scp>T</scp> cells
resolves10.4049/jimmunol.1501728
POSH Regulates CD4+ T Cell Differentiation and Survival
resolves10.1074/jbc.M704321200
Regulation of the Pro-apoptotic Scaffolding Protein POSH by Akt
resolves10.1242/dev.125.6.1049
Systematic gain-of-function genetics in <i>Drosophila</i>
resolves10.1016/S1673-8527(09)60080-1
POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila
resolves10.1038/ng1887
Delineation of a Fat tumor suppressor pathway
resolves10.1016/j.devcel.2008.01.007
The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway
resolves10.1016/j.cell.2006.07.013
The Hippo Pathway Regulates the bantam microRNA to Control Cell Proliferation and Apoptosis in Drosophila
resolves10.1101/gad.12.4.557
puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
resolves10.1016/j.stem.2008.10.016
Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila
resolves10.1242/dev.060483
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
resolves10.1073/pnas.1012759107
Hippo signaling regulates <i>Drosophila</i> intestine stem cell proliferation through multiple pathways
resolves10.1242/dev.052506
The Hippo pathway regulates intestinal stem cell proliferation during<i>Drosophila</i>adult midgut regeneration
resolves10.1016/j.cub.2010.07.041
Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation
resolves10.1073/pnas.1004060107
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in <i>Drosophila</i>
resolves10.1016/j.cub.2010.01.055
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
resolves10.1073/pnas.1004279107
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
resolves10.1016/j.cub.2010.03.019
Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded
resolves10.1016/S0960-9822(99)00277-8
A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila
resolves10.1016/0092-8674(95)90053-5
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of drosophila
resolves10.1038/cr.2014.166
SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila
resolves10.1016/j.cub.2006.09.045
Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway
resolves10.1016/j.cub.2006.09.004
The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway
resolves10.1016/j.cub.2006.09.005
The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size
resolves10.1186/1471-213X-11-57
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling
resolves10.1016/j.ydbio.2010.11.036
Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors
resolves10.1038/onc.2008.341
Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
resolves10.1038/nrc3461
Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics
resolves10.1146/annurev-genet-110711-155414
Dissecting Social Cell Biology and Tumors Using <i>Drosophila</i> Genetics
resolves10.1016/bs.ctdb.2016.07.008
Modeling Human Cancers in Drosophila
resolves10.1038/nrc1994
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
resolves10.1038/nrc1881
Ubiquitin ligases: cell-cycle control and cancer
resolves10.1073/pnas.1101273108
Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability
resolves10.1038/ncb3073
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
resolves10.1038/ncomms7314
NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway
resolves10.1093/carcin/bgt338
SH3RF2 functions as an oncogene by mediating PAK4 protein stability
resolves10.1101/gad.1978810
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
resolves10.1073/pnas.1415020112
Impaired Hippo signaling promotes Rho1–JNK-dependent growth
resolves10.1080/19336934.2017.1336270
The dark side of hippo signaling: A cancer promoter role
resolves10.1073/pnas.1621359114
Hippo signaling promotes JNK-dependent cell migration
resolves10.1038/cdd.2013.154
Bendless modulates JNK-mediated cell death and migration in Drosophila
resolves10.1038/cddis.2015.111
Wallenda regulates JNK-mediated cell death in Drosophila
resolves10.1093/genetics/146.1.245
Isolation of Mutations in the Drosophila Homologues of the Human <i>Neurofibromatosis 2</i> and Yeast <i>CDC42</i> Genes Using a Simple and Efficient Reverse-Genetic Method
resolves10.1016/j.devcel.2008.01.006
The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control
resolves10.1002/(SICI)1520-6408(1997)20:2<103::AID-DVG3>3.0.CO;2-B
Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs
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