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Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance

https://doi.org/10.1074/jbc.m109.018010
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Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

7 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 38 checked references that resolve
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Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitutions of Leucine 22
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Critical Role of Phenylalanine 34 of Human Dihydrofolate Reductase in Substrate and Inhibitor Binding and in Catalysis
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Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme
resolves10.1177/1087057108318783
2-Tier Bacterial and In Vitro Selection of Active and Methotrexate-Resistant Variants of Human Dihydrofolate Reductase
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Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH
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Increasing Methotrexate Resistance by Combination of Active-site Mutations in Human Dihydrofolate Reductase
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Crystal structure of human dihydrofolate reductase complexed with folate
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Structure determination of tetrahydroquinazoline antifolates in complex with human and<i>Pneumocystis carinii</i>dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry
resolves10.1107/S0907444903014963
Analysis of three crystal structure determinations of a 5-methyl-6-<i>N</i>-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
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Analysis of two polymorphic forms of a pyrido[2,3-<i>d</i>]pyrimidine N9—C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase
resolves10.1021/jm980081y
Structure-Based Design and Synthesis of Lipophilic 2,4-Diamino-6-Substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductases and Potential Antitumor Agents
resolves10.1021/bi971711l
Comparison of Two Independent Crystal Structures of Human Dihydrofolate Reductase Ternary Complexes Reduced with Nicotinamide Adenine Dinucleotide Phosphate and the Very Tight-Binding Inhibitor PT523<sup>,</sup>
resolves10.1038/2632
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Ex vivo expansion and selection of human CD34+ peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer
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NMR Investigation of Tyr105 Mutants in TEM-1 β-Lactamase
resolves10.1016/S0076-6879(97)76065-8
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Likelihood-enhanced fast rotation functions
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Atomic Structures of Human Dihydrofolate Reductase Complexed with NADPH and Two Lipophilic Antifolates at 1.09Å and 1.05Å Resolution
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Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate
resolves10.1002/prot.21131
New insights into DHFR interactions: Analysis of <i>Pneumocystis carinii</i> and mouse DHFR complexes with NADPH and two highly potent 5‐(ω‐carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions
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Implications of protein flexibility for drug discovery
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Intrinsic dynamics of an enzyme underlies catalysis
resolves10.1016/S0021-9258(19)81516-8
Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase.
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Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin
The 7 references without a DOI — listed, not checked
no DOI — not checked10.1074/jbc.M109.018010_bib1
no DOI — not checked10.1074/jbc.M109.018010_bib9
no DOI — not checked10.1074/jbc.M109.018010_bib25
no DOI — not checked10.1074/jbc.M109.018010_bib26
no DOI — not checked10.1074/jbc.M109.018010_bib30
no DOI — not checked10.1074/jbc.M109.018010_bib31
no DOI — not checked10.1074/jbc.M109.018010_bib40
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