Reference health
Systemic drugs with impact on osteoarthritis
153/153 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 153 checked references that resolve
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A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2
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A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis – the HUMOR trial
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Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
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Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: Implications for human efficacy and toxicity
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The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review
resolves10.1089/ten.tea.2014.0668
The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells
resolves10.1080/03602532.2016.1277737
Systemic drugs that influence titanium implant osseointegration
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The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial
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Comparing the effect of Glucosamine and Glucosamine With Alendronate in Symptomatic Relieve of Degenerative Knee Joint Disease: A Double- blind Randomized Clinical Trial Study
resolves10.1016/j.joca.2015.07.008
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration
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Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: A new potential treatment of osteoarthritis
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Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature
resolves10.1002/art.22160
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: Results of the two‐year multinational knee osteoarthritis structural arthritis study
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Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: Cartilage oligomeric matrix protein counteracts type IX collagen–induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures
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Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo‐controlled, double‐blind trial
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Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
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Non-surgical management of knee osteoarthritis: where are we now and where do we need to go?
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A Double-Blind, Active-Controlled Clinical Trial of Sodium Bicarbonate and Calcium Gluconate in the Treatment of Bilateral Osteoarthritis of the Knee
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Structural and Mechanical Differences between Collagen Homo- and Heterotrimers: Relevance for the Molecular Origin of Brittle Bone Disease
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Ascorbic acid provides protection for human chondrocytes against oxidative stress
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Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
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Activity and potential role of licofelone in the management of osteoarthritis
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24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
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A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
resolves10.1002/art.27436
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4
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Protective Effects of Many <i>Citrus</i> Flavonoids on Cartilage Degradation Process
resolves10.1016/j.joca.2008.09.002
The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment
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Chondroprotective effects of zoledronic acid on articular cartilage in dogs with experimentally induced osteoarthritis
resolves10.1016/j.joca.2016.01.112
Vitamin D supplementation for the management of knee osteoarthritis: A randomized controlled trial
resolves10.1007/s40266-019-00666-9
Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis
resolves10.1053/joca.2000.0365
Interindividual variability and correlation among morphological parameters of knee joint cartilage plates: analysis with three-dimensional MR imaging
resolves10.1177/0363546514533777
Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee
resolves10.1177/1759720X12448454
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis
resolves10.1016/j.joca.2008.01.005
Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis
resolves10.3390/nu8040233
Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet
resolves10.1046/j.1365-2036.2003.01792.x
Ursodeoxycholic acid — adverse effects and drug interactions
resolves10.1002/art.20384
Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor–mediated arthritis
resolves10.1097/00003086-198010000-00037
Ultrastructure of the Articular Cartilage After Systemic Administration of Hydrocortisone in the Rabbit
resolves10.1136/annrheumdis-2014-207169
Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose
resolves10.3390/nu10040471
Zinc Protects Articular Chondrocytes through Changes in Nrf2-Mediated Antioxidants, Cytokines and Matrix Metalloproteinases
resolves10.1038/emm.2015.88
Crosstalk between FLS and chondrocytes is regulated by HIF-2α-mediated cytokines in arthritis
resolves10.1093/rheumatology/keq217
Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway
resolves10.1016/j.bbrc.2016.05.126
Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro
resolves10.1001/jama.2016.1961
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis
resolves10.3899/jrheum.160226
The Effect of Aging and Mechanical Loading on the Metabolism of Articular Cartilage
resolves10.1002/art.23638
Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis
resolves10.1186/1749-799X-9-14
Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague–Dawley rats
resolves10.1016/j.joca.2014.12.019
Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials
resolves10.1016/j.joca.2016.07.017
Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future
resolves10.1016/j.joca.2006.03.014
Calcitonin is involved in cartilage homeostasis: Is calcitonin a treatment for OA?
resolves10.1186/s13075-015-0546-0
Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice
resolves10.1016/j.joca.2005.10.003
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
resolves10.1016/j.ccr.2008.01.027
Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
resolves10.55460/JLSS-PG9B
Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis
resolves10.1002/art.20776
Role of interleukin‐1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage
resolves10.1053/joca.2002.0856
Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice
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Rebamipide: A novel agent in the treatment of recurrent aphthous ulcer and Behcet′s syndrome
resolves10.3390/ijms141019705
The COX-2 Selective Blocker Etodolac Inhibits TNFα-Induced Apoptosis in Isolated Rabbit Articular Chondrocytes
resolves10.1053/joca.2001.0489
Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice
resolves10.1002/art.38314
Effect of Oral Glucosamine on Joint Structure in Individuals With Chronic Knee Pain: A Randomized, Placebo‐Controlled Clinical Trial
resolves10.1136/annrheumdis-2011-200970
Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial
resolves10.1016/j.joca.2012.11.010
Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair
resolves10.1089/ten.teb.2015.0300
Repositioning Bevacizumab: A Promising Therapeutic Strategy for Cartilage Regeneration
resolves10.1016/j.joca.2015.06.005
Leptin protects rat articular chondrocytes from cytotoxicity induced by TNF-α in the presence of cyclohexamide
resolves10.1111/jphp.12379
Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis
resolves10.1016/j.joca.2015.08.013
Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-β1 in ovariectomized rats
resolves10.1136/bjsports-2016-097333
Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis
resolves10.1016/j.joca.2015.07.022
Systemic administration of strontium or NBD peptide ameliorates early stage cartilage degradation of mouse mandibular condyles
resolves10.3109/03602532.2015.1124889
In quest of optimal drug-supported and targeted bone regeneration in the cranio facial area: a review of techniques and methods
resolves10.1080/02726351.2017.1331287
The role of BMP-2, low-level laser therapy and low x-ray doses in dental follicle stem cell migration
resolves10.1186/s12896-015-0229-6
Dental follicle stem cells in bone regeneration on titanium implants
resolves10.1136/annrheumdis-2012-202485
Randomised, controlled trial of avocado–soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study
resolves10.1001/jama.2012.164487
Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis
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Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial
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The impact of proton pump inhibitors on bone regeneration and implant osseointegration
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Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats
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Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?
resolves10.4110/in.2014.14.1.45
Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats
resolves10.1016/j.joca.2012.08.002
Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes
resolves10.1186/s13075-014-0427-y
Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis
resolves10.1136/bmjopen-2017-017652
Evolution of pain at 3 months by oral resveratrol in knee osteoarthritis (ARTHROL): protocol for a multicentre randomised double-blind placebo-controlled trial
resolves10.1016/j.joca.2011.01.008
Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover
resolves10.1007/s10067-013-2338-8
Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial
resolves10.1101/gad.231969.113
Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways
resolves10.1053/joca.2002.0868
AG-041R stimulates cartilage matrix synthesis without promoting terminal differentiation in rat articular chondrocytes
resolves10.1016/j.joca.2013.01.008
Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo
resolves10.3904/kjim.2018.460
Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis
resolves10.1016/j.acthis.2009.04.005
The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage
resolves10.3944/AOTT.2013.3136
Protective effect of zoledronic acid on corticosteroidinduced chondrocyte apoptosis
resolves10.1248/bpb.b17-00161
Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin
resolves10.1007/s00011-014-0794-5
Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis
resolves10.1007/s10067-010-1384-8
Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee
resolves10.1136/annrheumdis-2012-201710
Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
resolves10.1186/s13075-016-1149-0
Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study
resolves10.1186/1746-6148-10-97
Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis
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Hyaluronic Acid Suppresses the Expression of Metalloproteinases in Osteoarthritic Cartilage Stimulated Simultaneously by Interleukin 1β and Mechanical Load
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Type II collagen degradation and its regulation in articular cartilage in osteoarthritis
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Lactoferrin from Camelus dromedarius inhibits nuclear transcription Factor-kappa B activation, cyclooxygenase-2 expression and prostaglandin E2 production in stimulated human chondrocytes
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Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
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Strontium ranelate in the treatment of knee osteoarthritis: new insights and emerging clinical evidence
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Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis
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Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction
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Long‐Term Safety and Efficacy of Fulranumab in Patients With Moderate‐to‐Severe Osteoarthritis Pain: A Phase II Randomized, Double‐Blind, Placebo‐Controlled Extension Study
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Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial
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Functional Outcomes After Surgical Management of Articular Cartilage Lesions in the Knee: A Systematic Literature Review to Guide Postoperative Rehabilitation
resolves10.1016/j.joca.2010.06.005
Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins
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The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial
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The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model
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The Basic Science of Articular Cartilage: Structure, Composition, and Function
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Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ
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Long‐term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up‐regulation of MMP‐3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs
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Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period
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Lithium chloride prevents interleukin‐1β induced cartilage degradation and loss of mechanical properties
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Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis
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<i>In Vitro</i>Biocompatibility of Human Endothelial Cells with Collagen-Doxycycline Matrices
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Systemically administered rhBMP‐2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice
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Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway
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Zoledronic Acid Effect on Chondrocyte Apoptosis in Degenerative Osteoarthritis Model
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Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?
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Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials
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Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit
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Human Notch-1 Inhibits NF-κB Activity in the Nucleus Through a Direct Interaction Involving a Novel Domain
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Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study
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Does statin use have a disease modifying effect in symptomatic knee osteoarthritis? Study protocol for a randomised controlled trial
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Aspirin is associated with reduced cartilage loss in knee osteoarthritis: Data from a cohort study
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Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
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Effect of Naringin on Monosodium Iodoacetate-Induced Osteoarthritis Pain in Rats
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Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis
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ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’
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Non-steroidal Anti-inflammatory Drugs Inhibit Nitric Oxide-induced Apoptosis and Dedifferentiation of Articular Chondrocytes Independent of Cyclooxygenase Activity
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Biphasic Activation of Nuclear Factor-Kappa B in Experimental Models of Subarachnoid Hemorrhage<i>In Vivo</i>and<i>In Vitro</i>
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The protective effects of Donepezil (DP) against cartilage matrix destruction induced by TNF-α
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Recombinant human midkine stimulates proliferation of articular chondrocytes
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Naringin Protects Against Cartilage Destruction in Osteoarthritis Through Repression of NF-κB Signaling Pathway
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Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats
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Investigational drugs for the treatment of osteoarthritis, an update on recent developments
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Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis
The 16 references without a DOI — listed, not checked
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