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The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
37/37 checkable references clean · checked 2026-07-26
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
The 37 checked references that resolve
resolves10.4049/jimmunol.176.4.2439
Regulation of IgH Gene Assembly: Role of the Intronic Enhancer and 5′DQ52 Region in Targeting DHJH Recombination
resolves10.4049/jimmunol.0901978
In Vivo Redundant Function of the 3′
<i>IgH</i>
Regulatory Element HS3b in the Mouse
resolves10.1371/journal.pgen.1000332
A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation
resolves10.1084/jem.20091280
Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region
resolves10.1074/jbc.M109.098251
The Mouse Immunoglobulin Heavy Chain V-D Intergenic Sequence Contains Insulators That May Regulate Ordered V(D)J Recombination
resolves10.1016/S1074-7613(00)80592-0
Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription
resolves10.1073/pnas.1015954107
Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination
resolves10.1084/jem.20110118
Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
resolves10.4049/jimmunol.1202082
Identification of Core DNA Elements That Target Somatic Hypermutation
resolves10.4049/jimmunol.180.4.2019
Cutting Edge: A <i>cis</i>-Acting DNA Element Targets AID-Mediated Sequence Diversification to the Chicken Ig Light Chain Gene Locus
resolves10.1073/pnas.0901368106
H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination
resolves10.1182/blood-2006-02-005355
Regulation of ϵ germline transcription and switch region mutations by IgH locus 3′ enhancers in transgenic mice
resolves10.1084/jem.188.8.1421
Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers
resolves10.1007/s12026-009-8142-5
Controlling somatic hypermutation in immunoglobulin variable and switch regions
resolves10.1182/blood-2002-12-3827
The immunoglobulin heavy-chain locus hs3b and hs4 3′ enhancers are dispensable for VDJ assembly and somatic hypermutation
resolves10.1084/jem.20062409
Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T
resolves10.4049/jimmunol.166.4.2540
Deletion of the DQ52 Element Within the Ig Heavy Chain Locus Leads to a Selective Reduction in VDJ Recombination and Altered D Gene Usage
resolves10.1016/j.cell.2010.09.017
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
resolves10.1073/pnas.0507090102
Elucidation of IgH intronic enhancer functions via germ-line deletion
resolves10.1126/science.1218692
AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells
resolves10.1016/S1074-7613(01)00181-9
Localization of the 3′ IgH Locus Elements that Effect Long-Distance Regulation of Class Switch Recombination
resolves10.1074/jbc.M112.341024
Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination
resolves10.1073/pnas.96.4.1526
Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions
resolves10.4049/jimmunol.167.2.811
A Pivotal Role for DNase I-Sensitive Regions 3b and/or 4 in the Induction of Somatic Hypermutation of IgH Genes
resolves10.1128/MCB.06138-11
Cross Talk between Immunoglobulin Heavy-Chain Transcription and RNA Surveillance during B Cell Development
resolves10.4049/jimmunol.179.9.6033
The 3′
<i>IgH</i>
Locus Control Region Is Sufficient to Deregulate a c-
<i>myc</i>
Transgene and Promote Mature B Cell Malignancies with a Predominant Burkitt-Like Phenotype
resolves10.1016/S0161-5890(97)00065-5
Evaluation of the role of the 3′α heavy chain enhancer [3′αE(hs1,2)] in Vh gene somatic hypermutation
resolves10.4049/jimmunol.0900214
Ig Synthesis and Class Switching Do Not Require the Presence of the hs4 Enhancer in the 3′ IgH Regulatory Region
resolves10.1182/blood-2010-01-264689
Genomic deletion of the whole IgH 3′ regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes
resolves10.4049/jimmunol.180.10.6725
The Downstream Transcriptional Enhancer, Ed, Positively Regulates Mouse Igκ Gene Expression and Somatic Hypermutation
resolves10.1084/jem.20061835
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
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