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Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

https://doi.org/10.1093/brain/awaa090
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1 of 67 checkable references need attention · checked 2026-07-25

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

References needing attention

marked retracted — notice via Crossref, record curated by Retraction Watch10.1186/s40478-017-0445-5
RETRACTED ARTICLE: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
The 66 checked references that resolve
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Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation
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Glia and alpha-synuclein in neurodegeneration: A complex interaction
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Extracellular vesicles round off communication in the nervous system
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The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia
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Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD
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α-Synuclein-carrying extracellular vesicles in Parkinson’s disease: deadly transmitters
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Pathogenic Lysosomal Depletion in Parkinson's Disease
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Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein
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Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
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Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons
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Neuroinflammation contributes to autophagy flux blockage in the neurons of rostral ventrolateral medulla in stress-induced hypertension rats
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
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Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
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β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors
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resolves10.1172/JCI43366
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
resolves10.1126/scisignal.aau4543
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
resolves10.1523/JNEUROSCI.5610-12.2013
MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration
resolves10.1038/nri3705
Innate immune activation in neurodegenerative disease
resolves10.1016/S1353-8020(11)70065-7
Neuroinflammation in Parkinson's disease
resolves10.1007/s00192-016-2952-5
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resolves10.1038/nrneurol.2015.197
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resolves10.1242/jcs.01620
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Origins and Effects of Extracellular α-synuclein: Implications in Parkinson’s Disease
resolves10.1523/JNEUROSCI.3809-03.2004
Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
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α-Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1
resolves10.1126/science.1227157
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
resolves10.1084/jem.20112457
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
resolves10.1126/science.aah3374
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
resolves10.1111/imr.12298
E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses
resolves10.1080/15548627.2017.1395992
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
resolves10.1016/j.nbd.2015.12.018
Dynamic structural flexibility of α-synuclein
resolves10.1093/brain/awn109
Debris clearance by microglia: an essential link between degeneration and regeneration
resolves10.4161/auto.36436
Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
resolves10.4049/jimmunol.179.3.1913
Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages
resolves10.1093/brain/awv346
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
resolves10.1091/mbc.e13-10-0574
Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization
resolves10.1016/j.nbd.2009.11.004
Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
resolves10.1126/science.1153124
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
resolves10.1523/JNEUROSCI.1629-14.2014
ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein
resolves10.3390/ijms18020469
Potential Modes of Intercellular α-Synuclein Transmission
resolves10.1186/2051-5960-1-2
The prion hypothesis in Parkinson's disease: Braak to the future
resolves10.1038/nprot.2014.143
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
resolves10.1016/j.neuron.2011.08.033
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
resolves10.1074/jbc.M300227200
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
resolves10.1038/s41419-019-1404-9
Microglia as modulators of exosomal alpha-synuclein transmission
resolves10.1038/nm.3111
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
resolves10.1007/s12035-015-9593-4
Microglia-Mediated Inflammation and Neurodegenerative Disease
resolves10.1096/fj.04-2751com
Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease
resolves10.1111/jnc.12340
The Parkinson's disease‐associated gene <i><scp>PINK</scp>1</i> protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1
resolves10.2353/ajpath.2007.060524
Regulation of Autophagy by Extracellular Signal-Regulated Protein Kinases During 1-Methyl-4-Phenylpyridinium-Induced Cell Death
The 4 references without a DOI — listed, not checked
no DOI — not checkedApoptosis and autophagy in nigral neurons of patients with Parkinson’s disease
no DOI — not checkedParkinson’s Disease Society Brain Bank, London: overview and research
no DOI — not checkedA contribution to the method of mortality tables and potential demography for measurement of general health status
no DOI — not checked2020052115181840400_awaa090-B58
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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