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Phosphatidylethanolamine <i>N</i> ‐methyltransferase <i>(PEMT)</i> gene expression is induced by estrogen in human and mouse primary hepatocytes

https://doi.org/10.1096/fj.07-8227com
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63/63 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

7 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 63 checked references that resolve
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Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
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Choline availability alters embryonic development of the hippocampus and septum in the rat
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Choline Availability During Embryonic Development Alters Progenitor Cell Mitosis in Developing Mouse Hippocampus
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Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation
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Choline-Induced Spatial Memory Facilitation Correlates with Altered Distribution and Morphology of Septal Neurons
resolves10.1016/S0149-7634(03)00069-1
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan
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Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos
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Periconceptional Dietary Intake of Choline and Betaine and Neural Tube Defects in Offspring
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Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load
resolves10.1093/ajcn/80.1.163
Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts
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Hyperhomocysteinemia:<i>An Emerging and Important Risk Factor for Thromboembolic and Cardiovascular Disease</i>
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Concentrations of Choline-Containing Compounds and Betaine in Common Foods
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Erratum
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Ad Libitum Choline Intake in Healthy Individuals Meets or Exceeds the Proposed Adequate Intake Level,
resolves10.1042/bst0260337
Why has phosphatidylethanolamine <i>N</i>-methyltransferase survived in evolution?
resolves10.1016/0006-3002(61)90745-4
Methyl transfering enzyme system of microsomes in the biosynthesis of lecithin (phosphatidylcholine)
resolves10.1016/S0005-2760(97)00108-2
Phosphatidylethanolamine N-methyltransferase from liver
resolves10.1093/jn/125.12.3049
Pregnancy and Lactation Are Associated with Diminished Concentrations of Choline and Its Metabolites in Rat Liver
resolves10.1210/endo-119-6-2611
Estradiol Activates Methylating Enzyme(s) Involved in the Conversion of Phosphatidylethanolamine to Phosphatidylcholine in Rat Pituitary Membranes*
resolves10.1016/S0022-2275(20)39478-5
Estradiol- and testosterone-induced alterations in phosphatidylcholine and triglyceride synthesis in hepatic endoplasmic reticulum
resolves10.1042/bst0090098
Effect of diethylstilboestrol on phosphatidylcholine biosynthesis in the liver of roosters
resolves10.1002/hep.1840210617
Protective effect of hepatocyte growth factor on interferon-gamma—induced cytotoxicity in mouse hepatocytes
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The role of estrogens on the proliferation of human breast tumor cells (MCF-7)
resolves10.1073/pnas.83.8.2496
Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.
resolves10.1006/meth.2001.1262
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
resolves10.1074/jbc.275.8.5867
Proteinase Inhibitor 9, an Inhibitor of Granzyme B-mediated Apoptosis, Is a Primary Estrogen-inducible Gene in Human Liver Cells
resolves10.1016/S0021-9258(17)44512-1
Pitfalls and problems in studies on the methylation of phosphatidylethanolamine.
resolves10.1073/pnas.2136655100
Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage
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Dragon ERE Finder version 2: a tool for accurate detection and analysis of estrogen response elements in vertebrate genomes
resolves10.1016/S1388-1981(01)00122-6
Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene1Sequence data from this article have been deposited with the GenBank Data Library under accession numbers AF294460–AF294468 inclusive.1
resolves10.1016/S0022-2275(20)37483-6
Characterization of the murine phosphatidylethanolamine N-methyltransferase-2 gene
resolves10.1038/ng1901
Genome-wide analysis of estrogen receptor binding sites
resolves10.1101/gr.817703
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resolves10.1093/nar/27.1.318
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Characterization of choline transport at maternal and fetal interfaces of the perfused guinea‐pig placenta.
resolves10.1016/0009-8981(85)90267-0
Measurement of free choline concentrations in maternal and neonatal blood by micropyrolysis gas chromatography
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Choline and choline esters in human and rat milk and in infant formulas
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Maternal Nutrient Intakes and Risk of Orofacial Clefts
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Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum
resolves10.1016/j.devbrainres.2005.07.002
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus
resolves10.1159/000048701
Maternal Choline Availability Alters the Localization of p15Ink4B and p27Kip1 Cyclin-Dependent Kinase Inhibitors in the Developing Fetal Rat Brain Hippocampus
resolves10.1080/1028415031000084418
Choline Availability During Embryonic Development Alters the Localization of Calretinin in Developing and Aging Mouse Hippocampus
resolves10.1023/A:1022411510636
Choline Availability Modulates the Expression of TGFβ1 and Cytoskeletal Proteins in the Hippocampus of Developing Rat Brain
resolves10.1096/fj.05-4707com
Dietary choline deficiency alters global and gene‐specific DNA methylation in the developing hippocampus of mouse fetal brains
resolves10.1152/jn.1998.79.4.1790
Prenatal Dietary Choline Supplementation Decreases the Threshold for Induction of Long-Term Potentiation in Young Adult Rats
resolves10.1097/00001756-199709290-00010
Perinatal choline supplementation increases the threshold for chunking in spatial memory
resolves10.1002/dev.420210405
Pre‐ and postnatal choline supplementation produces long‐term facilitation of spatial memory
resolves10.1042/bj2000321
Effect of diethylstilboestrol on phosphatidylcholine biosynthesis and choline metabolism in the liver of roosters
resolves10.1016/0005-2760(81)90269-1
Diethylstilbestrol treatment modulates the enzymatic activities of phosphatidylcholine biosynthesis in rooster liver
resolves10.1210/endo-121-2-569
Variations of Phospholipid Methyltransferase(s) Activity in the Rat Pituitary: Estrous Cycle and Sex Differences*
resolves10.1093/nar/gkh943
Computational method for discovery of estrogen responsive genes
resolves10.1210/endo.143.6.8855
Estrogen Activates the High-Density Lipoprotein Receptor Gene via Binding to Estrogen Response Elements and Interaction with Sterol Regulatory Element Binding Protein-1A
resolves10.1093/molehr/8.2.167
Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter
resolves10.1124/mol.56.1.31
Characterization and Implications of Estrogenic Down-Regulation of Human Catechol-<i>O</i>-Methyltransferase Gene Transcription
resolves10.1074/jbc.273.45.29321
Sequence Requirements for Estrogen Receptor Binding to Estrogen Response Elements
resolves10.1210/me.2003-0441
Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse
resolves10.1210/mend.11.13.0039
Effects of Multiple Estrogen Responsive Elements, Their Spacing, and Location on Estrogen Response of Reporter Genes
resolves10.1074/jbc.270.39.22777
Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers
resolves10.1073/pnas.0505575102
Location analysis of estrogen receptor α target promoters reveals that FOXA1 defines a domain of the estrogen response
resolves10.1016/j.cell.2005.05.008
Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1
resolves10.1096/fj.06-5734com
Common genetic polymorphisms affect the human requirement for the nutrient choline
The 7 references without a DOI — listed, not checked
no DOI — not checkedDietary Reference Intakes for Folate, Thiamin, Riboflavin, Niacin, Vitamin B12, Panthothenic Acid, Biotin, and Choline
no DOI — not checkedGender and menopausal status influence human dietary requirements for the nutrient choline
no DOI — not checkedSexually differentiated response to choline in choline deficiency and ethionine intoxication
no DOI — not checkedA gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phos-phatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice
no DOI — not checkedIsolation and culture of primary human hepatocytes
no DOI — not checkedEvidence of saturable uptake mechanisms at maternal and fetal sides of the perfused human placenta by rapid paired-tracer dilution: studies with calcium and choline
no DOI — not checkedSteroid hormone levels during pregnancy and incidence of maternal breast cancer
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