Reference health
Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension
1 of 125 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1152/ajplung.00353.2007
Protein kinase Cδ regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation
The 124 checked references that resolve
resolves10.1016/S0140-6736(12)61766-8
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
resolves10.1073/pnas.91.16.7583
Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.
resolves10.1124/jpet.105.096115
Kv Channels Contribute to Nitric Oxide- and Atrial Natriuretic Peptide-Induced Relaxation of a Rat Conduit Artery
resolves10.1161/01.CIR.91.5.1314
Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo
resolves10.1161/01.CIR.91.6.1732
Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension
resolves10.1161/01.CIR.87.1.86
Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels.
resolves10.1080/00365519950185724
Impaired endothelium-dependent relaxation in mesenteric arteries of reduced renal mass hypertensive rats
resolves10.1097/00004872-200208000-00020
Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats
resolves10.1016/j.niox.2013.08.005
Agmatine induced NO dependent rat mesenteric artery relaxation and its impairment in salt-sensitive hypertension
resolves10.1161/01.HYP.0000122804.32680.c9
Reduced NOS3 Phosphorylation Mediates Reduced NO/cGMP Signaling in Mesenteric Arteries of Deoxycorticosterone Acetate-Salt Hypertensive Rats
resolves10.1161/01.RES.87.10.840
Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress
resolves10.1161/01.CIR.94.6.1298
Defective
<scp>l</scp>
-Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients
resolves10.1161/01.CIR.0000149748.79945.52
Impaired
<scp>l</scp>
-Arginine Transport and Endothelial Function in Hypertensive and Genetically Predisposed Normotensive Subjects
resolves10.1016/S0735-1097(98)00391-X
Impairment of the nitric oxide–mediated vasodilator response to mental stress in hypertensive but not in hypercholesterolemic patients
resolves10.1161/01.ATV.0000081742.92006.59
Asymmetric Dimethylarginine Causes Hypertension and Cardiac Dysfunction in Humans and Is Actively Metabolized by Dimethylarginine Dimethylaminohydrolase
resolves10.1038/aps.2010.127
COX-mediated endothelium-dependent contractions: from the past to recent discoveries
resolves10.1111/j.1476-5381.2011.01276.x
Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products
resolves10.1161/HYPERTENSIONAHA.111.00995
Endothelial Dysfunction in Small Arteries of Essential Hypertensive Patients
resolves10.1161/CIRCRESAHA.108.179770
Cyclooxygenase-2–Derived Prostaglandin F
<sub>2α</sub>
Mediates Endothelium-Dependent Contractions in the Aortae of Hamsters With Increased Impact During Aging
resolves10.1089/ars.2010.3874
Oxidative Stress-Dependent Cyclooxygenase-2-Derived Prostaglandin F
<sub>2α</sub>
Impairs Endothelial Function in Renovascular Hypertensive Rats
resolves10.1089/ars.2013.5519
Uncoupling Protein-2 Mediates DPP-4 Inhibitor-Induced Restoration of Endothelial Function in Hypertension Through Reducing Oxidative Stress
resolves10.1073/pnas.0409594102
Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
resolves10.1161/CIRCRESAHA.110.222794
Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation
resolves10.1093/eurheartj/ehp061
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis
resolves10.2215/CJN.08490910
Asymmetric Dimethylarginine and Clinical Outcomes in Chronic Kidney Disease
resolves10.1016/0140-6736(92)90865-Z
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
resolves10.1681/ASN.2005121379
Molecular Mechanism for Elevation of Asymmetric Dimethylarginine and Its Role for Hypertension in Chronic Kidney Disease
resolves10.1007/s11897-012-0097-5
Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling
resolves10.1016/j.jhep.2005.02.036
Up-regulation of nNOS and associated increase in nitrergic vasodilation in superior mesenteric arteries in pre-hepatic portal hypertension
resolves10.1083/jcb.200601051
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
resolves10.1016/j.freeradbiomed.2010.04.004
Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease
resolves10.1074/jbc.M709250200
Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase
resolves10.1016/S0021-9258(18)38112-2
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
resolves10.1007/s00125-012-2557-6
The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes
resolves10.1016/j.cardiores.2004.10.040
Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells
resolves10.1172/JCI0214442
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
resolves10.1016/j.yjmcc.2009.09.011
Dihydrofolate reductase and biopterin recycling in cardiovascular disease
resolves10.1152/ajpheart.00823.2007
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
resolves10.1073/pnas.90.13.6252
Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.
resolves10.1074/jbc.271.44.27237
Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1
resolves10.1074/jbc.C100122200
Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase
resolves10.1161/hh1101.092677
Phosphorylation of Thr
<sup>495</sup>
Regulates Ca
<sup>2+</sup>
/Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity
resolves10.1038/21218
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
resolves10.1161/CIRCRESAHA.108.178467
An Ezrin/Calpain/PI3K/AMPK/eNOS
<sub>s1179</sub>
Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production
resolves10.1093/cvr/cvm010
CaM Kinase II-dependent pathophysiological signalling in endothelial cells
resolves10.1073/pnas.0511011103
Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism
resolves10.1172/JCI11235
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
resolves10.1161/CIRCRESAHA.108.189316
Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure
resolves10.1016/j.bbrc.2010.01.080
SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
resolves10.1161/CIRCRESAHA.110.222968
Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase
resolves10.1038/nature09599
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
resolves10.1089/ars.2011.3904
S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling
resolves10.1126/science.1062688
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
resolves10.1152/ajprenal.00199.2014
Role of caveolin 1 in AT<sub>1a</sub>receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney
resolves10.3317/jraas.2006.003
Role of Angiotensin II in Cardiovascular Disease — Therapeutic Implications of More Than a Century of Research
resolves10.1111/j.1365-201X.2004.01331.x
Exploring type I angiotensin (AT<sub>1</sub>) receptor functions through gene targeting
resolves10.1016/j.yjmcc.2009.07.025
Mechanistic insights into folic acid-dependent vascular protection: Dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: A novel HPLC-based fluorescent assay for DHFR activity
resolves10.1161/HYPERTENSIONAHA.111.181644
Role of Uncoupled Endothelial Nitric Oxide Synthase in Abdominal Aortic Aneurysm Formation
resolves10.1371/journal.pone.0088899
Recoupling of eNOS with Folic Acid Prevents Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E Null Mice
resolves10.2337/db06-0288
Attenuation of Angiotensin II Signaling Recouples eNOS and Inhibits Nonendothelial NOX Activity in Diabetic Mice
resolves10.1073/pnas.80.6.1546
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.
resolves10.1074/jbc.M109.041483
Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling
resolves10.1074/jbc.M809295200
Tetrahydrobiopterin Recycling, a Key Determinant of Endothelial Nitric-oxide Synthase-dependent Signaling Pathways in Cultured Vascular Endothelial Cells
resolves10.1159/000126927
Role of Angiotensin II on Dihydrofolate Reductase, GTP-Cyclohydrolase 1 and Nitric Oxide Synthase Expressions in Renal Ischemia-Reperfusion
resolves10.1161/ATVBAHA.112.252700
Vascular Function During Prolonged Progression and Regression of Atherosclerosis in Mice
resolves10.1172/JCI200314172
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
resolves10.1042/CS20050307
Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms
resolves10.1152/ajpheart.00835.2011
Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension
resolves10.2174/1389200024605073
Tetrahydrobiopterin Biosynthesis, Utilization and Pharmacological Effects
resolves10.1152/ajpheart.00007.2009
Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability
resolves10.1161/CIRCULATIONAHA.107.748236
Endothelium-Specific GTP Cyclohydrolase I Overexpression Attenuates Blood Pressure Progression in Salt-Sensitive Low-Renin Hypertension
resolves10.1161/01.ATV.0000110785.96039.f6
Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
resolves10.1074/jbc.M302227200
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
resolves10.1161/01.HYP.0000057421.28533.37
Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities
resolves10.1074/jbc.M004392200
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin
resolves10.1074/jbc.M002248200
Ascorbic Acid Enhances Endothelial Nitric-oxide Synthase Activity by Increasing Intracellular Tetrahydrobiopterin
resolves10.1172/JCI650
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.
resolves10.1152/ajpheart.01315.2010
Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy
resolves10.1161/01.CIR.102.18.2172
Endothelial Dysfunction of Coronary Resistance Arteries Is Improved by Tetrahydrobiopterin in Atherosclerosis
resolves10.1161/01.CIR.0000124223.00113.A4
gp91phox-Containing NADPH Oxidase Mediates Endothelial Dysfunction in Renovascular Hypertension
resolves10.1161/01.HYP.0000032100.23772.98
Role of p47
<sup>
<i>phox</i>
</sup>
in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
resolves10.1016/j.freeradbiomed.2005.12.035
Noxa1 is a central component of the smooth muscle NADPH oxidase in mice
resolves10.1016/S0165-6147(03)00233-5
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
resolves10.1111/j.1476-5381.2010.00920.x
Comparative pharmacology of chemically distinct NADPH oxidase inhibitors
resolves10.1161/HYPERTENSIONAHA.109.149187
Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition
resolves10.1016/j.cardiores.2006.01.022
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation☆
resolves10.1016/j.bbrc.2006.03.114
Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells
resolves10.1161/CIRCULATIONAHA.112.132159
NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis
resolves10.1021/cb100219n
A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells
resolves10.1016/j.freeradbiomed.2011.09.012
Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse
resolves10.1161/HYPERTENSIONAHA.108.112094
Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure
resolves10.1007/s00125-005-1857-5
Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation
resolves10.1161/01.CIR.0000092948.04444.C7
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
resolves10.1371/journal.pone.0099823
PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G+ -Toxins
resolves10.1152/ajpheart.01064.2002
Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning
resolves10.1074/jbc.M100229200
Reciprocal Phosphorylation and Regulation of Endothelial Nitric-oxide Synthase in Response to Bradykinin Stimulation
resolves10.1073/pnas.0704329104
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
resolves10.1074/jbc.M304471200
Synergistic Activation of Endothelial Nitric-oxide Synthase (eNOS) by HSP90 and Akt
resolves10.1074/jbc.M001644200
Reconstitution of an Endothelial Nitric-oxide Synthase (eNOS), hsp90, and Caveolin-1 Complex in Vitro
resolves10.1161/01.RES.0000031799.12850.1E
Chronic Hypoxia Increases Endothelial Nitric Oxide Synthase Generation of Nitric Oxide by Increasing Heat Shock Protein 90 Association and Serine Phosphorylation
resolves10.1172/JCI33338
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
The 6 references without a DOI — listed, not checked
no DOI — not checkedHeart disease and stroke statistics-2012 update: a report from the American Heart Association.
no DOI — not checkedEffect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers.
no DOI — not checkedTetrahydrobiopterin and eNOS dimermonomer ratio: a clue to eNOS uncoupling in diabetes Cardiovasc R
no DOI — not checkedMalignant hypertension produced by treatment with desoxycorticosterone acetate and sodium chloride.
no DOI — not checkedNADPH oxidase inhibitors: new antihypertensive agents J Cardiovasc P
no DOI — not checkedFulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
What this badge says. CiteStamped means the CHECKABLE references of this
work were clean at the dated check: each resolved to a known work in a public registry, and none
carried a retraction notice at that time. It says nothing about the quality, findings,
or importance of the work itself, and nothing about references deposited without a DOI.
checked 2026-07-22 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record
Embed this badge
Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.
<a href="https://citestamp.com/citestamped/10.1097/hjh.0000000000000587"><img src="https://citestamp.com/citestamped/10.1097/hjh.0000000000000587/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>
[](https://citestamp.com/citestamped/10.1097/hjh.0000000000000587)