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ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

https://doi.org/10.1101/2021.05.20.444938
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1 of 51 checkable references need attention · checked 2026-07-22

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References needing attention

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The 50 checked references that resolve
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Adipocyte-type fatty acid-binding protein as inter-compartmental shuttle for peroxisome proliferator activated receptor γ agonists in cultured cell
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Sortilin limits EGFR signaling by promoting its internalization in lung cancer
resolves10.1101/2020.01.12.903187
Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling
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Crystal Structure and Thermodynamic Analysis of Human Brain Fatty Acid-binding Protein
resolves10.1074/jbc.M115.647180
Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other
resolves10.1523/JNEUROSCI.2425-12.2013
The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain
resolves10.1007/s00109-014-1152-3
Sorting receptor sortilin—a culprit in cardiovascular and neurological diseases
resolves10.1073/pnas.0914984107
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
resolves10.1126/science.8346443
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
resolves10.1074/jbc.M114.618447
Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
resolves10.1016/0896-6273(94)90341-7
Brain lipid-binding protein (BLBP): A novel signaling system in the developing mammalian CNS
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resolves10.1101/cshperspect.a006312
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
resolves10.1016/j.neuron.2010.09.034
Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
resolves10.1038/nn2000
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An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease
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Identification of intracellular carriers for the endocannabinoid anandamide
resolves10.1016/j.bbrc.2010.10.121
Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking
resolves10.1073/pnas.95.8.4333
ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
resolves10.1016/j.cmet.2010.08.006
Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export
resolves10.1172/JCI6172
Apo E structure determines VLDL clearance and atherosclerosis risk in mice
resolves10.1186/1476-511X-8-2
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resolves10.1242/dev.120.9.2637
The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
resolves10.1186/1471-2407-6-97
Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma
resolves10.1093/abbs/gmz029
Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein
resolves10.1016/j.celrep.2019.02.027
SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
resolves10.3233/JAD-131961
Reductions in Endocannabinoid Levels and Enhanced Coupling of Cannabinoid Receptors in the Striatum are Accompanied by Cognitive Impairments in the AβPPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease
resolves10.1016/j.neures.2014.08.012
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resolves10.1074/jbc.M110.170076
Brain Fatty Acid-binding Protein and ω-3/ω-6 Fatty Acids
resolves10.3389/fphys.2012.00385
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resolves10.1111/j.1600-0854.2006.00429.x
The Lysosomal Trafficking of Acid Sphingomyelinase is Mediated by Sortilin and Mannose 6‐phosphate Receptor
resolves10.1093/emboj/20.9.2180
The sortilin cytoplasmic tail conveys Golgi–endosome transport and binds the VHS domain of the GGA2 sorting protein
resolves10.1620/tjem.214.213
Fatty Acid Binding Protein: Localization and Functional Significance in the Brain
resolves10.1111/j.1460-9568.2006.04855.x
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resolves10.1016/j.expneurol.2006.01.018
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
resolves10.1001/archneur.63.11.1545
Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease
resolves10.1007/BF02536067
Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease
resolves10.1016/j.bbrc.2016.07.096
Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells
resolves10.1172/JCI63563
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
resolves10.1111/jnc.13879
Docosahexaenoic acid up‐regulates both <scp>PI</scp>3K/<scp>AKT</scp>‐dependent <scp>FABP</scp>7–<scp>PPAR</scp>γ interaction and <scp>MKP</scp>3 that enhance <scp>GFAP</scp> in developing rat brain astrocytes
resolves10.1038/nn.2689
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
resolves10.1074/jbc.271.40.24711
Ligand Specificity of Brain Lipid-binding Protein
resolves10.1038/srep07130
DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease
resolves10.1038/s41467-020-19264-0
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
resolves10.1016/j.neuron.2020.02.034
Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways
resolves10.1073/pnas.0503689102
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
resolves10.1002/prca.200800111
An integrated LC‐ESI‐MS platform for quantitation of serum peptide ladders. Application for colon carcinoma study
resolves10.1021/pr700600n
Assigning Significance to Peptides Identified by Tandem Mass Spectrometry Using Decoy Databases
resolves10.1002/glia.23778
SorCS2 facilitates release of endostatin from astrocytes and controls post‐stroke angiogenesis
The 1 reference without a DOI — listed, not checked
no DOI — not checkedSORCS1 and SORCS3 control energy balance and orexigenic peptide production
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