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Opioid-Induced Respiratory Depression: A Mathematical Model for Fentanyl

https://doi.org/10.1109/tbme.2004.827344
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40/40 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

5 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 40 checked references that resolve
resolves10.1097/00000542-199907000-00023
Pharmacokinetic-Pharmacodynamic Modeling of the Respiratory Depressant Effect of Alfentanil 
resolves10.1139/y90-195
Quantitative integration of the cardiovascular system and synthesis of drug actions: another attempt
resolves10.1097/00000542-199809000-00009
Effects of Alfentanil on the Ventilatory Response to Sustained Hypoxia
resolves10.1097/00000542-197904000-00011
Fentanyl Disposition in Cerebrospinal Fluid and Plasma and Its Relationship to Ventilatory Depression in the Dog
resolves10.1093/bja/37.12.898
FACTORS INFLUENCING THE ARTERIAL OXYGEN TENSION DURING ANAESTHESIA WITH ARTIFICIAL VENTILATION
resolves10.1093/bja/41.1.28
METHODS OF ELEVATION OF Pco2 FOR RESTORATION OF SPONTANEOUS BREATHING AFTER ARTIFICIAL VENTILATION OF ANAESTHETIZED PATIENTS
resolves10.1097/00000542-198102000-00003
Interactions among Ventilation, the Circulation and the Uptake and Distribution of Halothane—Use of a Hybrid Computer Multiple Model
resolves10.1007/BF01059111
A mathematical model for dynamics of cardiovascular drug action: Application to intravenous dihydropyridines in healthy volunteers
resolves10.1056/NEJM197505222922106
Diminished Ventilatory Response to Hypoxia and Hypercapnia after Morphine in Normal Man
resolves10.1152/jappl.1979.47.1.112
Effects of morphine on ventilatory response to exercise
resolves10.1097/00000542-200109000-00029
Opioid Action on Respiratory Neuron Activity of the Isolated Respiratory Network in Newborn Rats
resolves10.1056/NEJM200010263431705
Effects of Intrathecal Morphine on the Ventilatory Response to Hypoxia
resolves10.1046/j.1365-2281.2001.00349.x
An integrated model of the human ventilatory control system: the response to hypercapnia
resolves10.1007/BF02364439
Computational expressions for blood oxygen and carbon dioxide concentrations
resolves10.1016/0034-5687(90)90074-9
Hypoxic depression of ventilation in humans: alternative models for the chemoreflexes
resolves10.1152/jappl.1993.74.4.2007
A mathematical model of the human ventilatory response to isocapnic hypoxia
resolves10.1152/jappl.1995.79.2.373
Hypoxic ventilatory decline: site of action
resolves10.1016/0034-5687(71)90054-5
Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats
resolves10.1097/00132586-196812000-00012
THE MAGNITUDE AND DURATION OF RESPIRATORY DEPRESSION DUE TO FENTANYL AND MEPERIDINE IN MAN
resolves10.1213/00000539-198311000-00002
Ventilatory Depression Related to Plasma Fentanyl Concentrations during and after Anesthesia in Humans
resolves10.1097/00000542-199706000-00016
Influences of Morphine on the Ventilatory Response to Isocapnic Hypoxia 
resolves10.1097/00000539-200110000-00028
The Concentration-Effect Relationship of the Respiratory Depressant Effects of Alfentanil and Fentanyl
resolves10.1097/00000542-199905000-00017
Sex Differences in Morphine-induced Ventilatory Depression Reside within the Peripheral Chemoreflex Loop 
resolves10.1016/0304-3959(90)90051-E
Steady-state infusions of opioids in human. II. Concentration-effect relationships and therapeutic margins
resolves10.1111/j.1399-6576.1984.tb02013.x
Ventilatory and Mental Effects of Alfentanil and Fentanyl
resolves10.1152/jappl.1985.59.6.1675
Opioids and breathing
resolves10.1046/j.1365-2044.1998.00519.x
The effect of low‐dose ketamine on fentanyl‐induced respiratory depression
resolves10.1097/00000542-199406000-00018
Effects of Morphine and Physostigmine on the Ventilatory Response to Carbon Dioxide
resolves10.1093/bja/73.5.583
Effects of surgical stimulation on the apnoeic thresholds for carbon dioxide during anaesthesia with sevoflurane
resolves10.1111/j.1365-2044.1985.tb11043.x
Variability of fentanyl pharmacokinetics in man
resolves10.1111/imj.1967.16.1.20
A CLINICAL METHOD FOR ASSESSING THE VENTILATORY RESPONSE TO CARBON DIOXIDE
resolves10.1093/bja/39.11.861
THE RESPIRATORY RESPONSE TO CARBON DIOXIDE DURING INNOVAR-NITROUS OXIDE ANAESTHESIA IN MAN
resolves10.1097/00000542-200302000-00008
Response Surface Modeling of Remifentanil–Propofol Interaction on Cardiorespiratory Control and Bispectral Index
resolves10.1097/00000542-196105000-00009
THE RESPIRATORY THRESHOLD FOR CARBON DIOXIDE IN ANESTHETIZED MAN Determination of Carbon Dioxide Threshold During Halothane Anesthesia
resolves10.1097/00000542-200106000-00011
Response Surface Modeling of Alfentanil-Sevoflurane Interaction on Cardiorespiratory Control and Bispectral Index
resolves10.1093/bja/65.2.155
CARBON DIOXIDE CYLINDERS ON ANAESTHETIC APPARATUS
resolves10.1093/bja/54.10.1087
PLASMA FENTANYL CONCENTRATIONS AND THE OCCURRENCE OF RESPIRATORY DEPRESSION IN VOLUNTEERS
resolves10.1109/10.668748
Pharmacokinetic-pharmacodynamic model for educational simulations
resolves10.1097/00000542-198503000-00005
EEG Quantitation of Narcotic Effect
resolves10.1093/bja/70.4.411
AN ALTERNATIVE METHOD OF INCREASING Pco2 USING APNOEA AND CONTINUOUS POSITIVE AIRWAY PRESSURE
The 5 references without a DOI — listed, not checked
no DOI — not checkedventilatory effects during and after continuous infusion of fentanyl or alfentanil
no DOI — not checkedintegration of respiratory responses to changes in alveolar partial pressures of co<formula><tex>$_2$</tex></formula> and o<formula><tex>$_2$</tex></formula> and in arterial ph
no DOI — not checkedthe additive effect of nitrous oxide on respiratory depression in patients having fentanyl or alfentanil infusions
no DOI — not checkedthe magnitude and duration of respiratory depression produced by fentanyl and fentanyl plus droperidol in man
no DOI — not checkedmetabolic control of blood flow with reference to heart, skeletal muscle and brain
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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