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Therapeutic Basis of Clinical Pain Modulation

https://doi.org/10.1111/cts.12282
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69/69 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 69 checked references that resolve
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Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain – Basic and therapeutic aspects
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Mechanism of Spinal Pain Transmission and Its Regulation
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Descending control of nociception: Specificity, recruitment and plasticity
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Pain Mechanisms: A New Theory
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Constructing and deconstructing the gate theory of pain
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Theories of pain: from specificity to gate control
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Whole body vibration therapy for painful diabetic peripheral neuropathy: A pilot study
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Reduction of pain and side effects in the treatment of solar lentigines with pneumatic skin flattening (PSF)
resolves10.1126/science.164.3878.444
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
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Current Research on Opioid Receptor Function
resolves10.1523/JNEUROSCI.1400-13.2013
Alterations in Endogenous Opioid Functional Measures in Chronic Back Pain
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Relationship Between Endogenous Opioid Function and Opioid Analgesic Adverse Effects
resolves10.1016/j.jpain.2010.05.006
The Endogenous Opioid System Is Not Involved in Modulation of Opioid-Induced Hyperalgesia
resolves10.1016/j.bbi.2010.06.008
Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain
resolves10.1097/00000542-200108000-00036
Opioid Peptide–expressing Leukocytes
resolves10.1097/AJP.0b013e31823ae69e
Comparing Pain Modulation and Autonomic Responses in Fibromyalgia and Irritable Bowel Syndrome Patients
resolves10.1016/j.neulet.2013.05.041
The dopamine agonist apomorphine enhances conditioned pain modulation in healthy humans
resolves10.1016/j.pneurobio.2009.10.010
Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis
resolves10.1016/j.pain.2010.09.034
In vivo patch-clamp analysis of dopaminergic antinociceptive actions on substantia gelatinosa neurons in the spinal cord
resolves10.1111/ejn.12174
Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue‐triggered ‘wanting’ for reward: entire core and medial shell mapped as substrates for <scp>PIT</scp> enhancement
resolves10.1111/pme.12139
Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole-Venule Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue
resolves10.1016/j.genhosppsych.2014.10.005
Comparison of the effects of escitalopram and nortriptyline on painful symptoms in patients with major depression
resolves10.1097/ALN.0000000000000324
Peripheral Nerve Injury Reduces Analgesic Effectsof Systemic Morphine via Spinal 5-Hydroxytryptamine 3 Receptors
resolves10.1016/S0022-3565(24)38213-8
Periaqueductal Gray Stimulation-Induced Inhibition of Nociceptive Dorsal Horn Neurons in Rats Is Associated with the Release of Norepinephrine, Serotonin, and Amino Acids
resolves10.1016/j.pain.2011.06.008
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain
resolves10.1016/j.pain.2011.09.021
Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E2 in the spinal cord
resolves10.1002/ejp.586
A selective<scp>α</scp><sub>2</sub><scp><sub>B</sub></scp>adrenoceptor agonist (A‐1262543) and duloxetine modulate nociceptive neurones in the medial prefrontal cortex, but not in the spinal cord of neuropathic rats
resolves10.1016/j.pain.2012.02.021
Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
resolves10.1097/SPC.0000000000000055
Descending pain modulation and chronification of pain
resolves10.1016/j.jpain.2011.12.004
The Association Between Polymorphisms in Serotonin-Related Genes and Pain Modulation Might Be of Importance for the Pathogenesis of Sudden Infant Death Syndrome
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Association Between Polymorphisms in Serotonin and Dopamine-Related Genes and Endogenous Pain Modulation
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Time-Dependent Cross Talk between Spinal Serotonin 5-HT<sub>2A</sub>Receptor and mGluR1 Subserves Spinal Hyperexcitability and Neuropathic Pain after Nerve Injury
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Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain
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Efficacy of Antidepressants as Analgesics: A Review
resolves10.1007/s00213-010-2037-y
Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors
resolves10.1016/j.bmcl.2010.05.078
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain
resolves10.1038/npp.2011.59
Cholecystokinin Exerts an Effect via the Endocannabinoid System to Inhibit GABAergic Transmission in Midbrain Periaqueductal Gray
resolves10.1016/j.pain.2011.09.028
Peripheral and spinal GABAergic regulation of incisional pain in rats
resolves10.1016/j.neuropharm.2011.03.017
A question of balance – Positive versus negative allosteric modulation of GABAA receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain
resolves10.1016/j.ejphar.2013.01.070
GABAA receptor modulation: Potential to deliver novel pain medicines?
resolves10.1016/j.pain.2010.12.034
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release
resolves10.1523/JNEUROSCI.5387-10.2011
Mitochondrial Reactive Oxygen Species Are Activated by mGluR5 through IP <sub>3</sub> and Activate ERK and PKA to Increase Excitability of Amygdala Neurons and Pain Behavior
resolves10.1155/2012/545386
Peripheral Galanin Receptor 2 as a Target for the Modulation of Pain
resolves10.1186/1744-8069-8-41
Differential Roles of Galanin on Mechanical and Cooling Responses at the Primary Afferent Nociceptor
resolves10.1016/j.npep.2011.08.002
Galanin receptor-expressing dorsal horn neurons: Role in nociception
resolves10.3389/fphar.2014.00072
Inhibition of visceral nociceptors
resolves10.1016/j.peptides.2013.02.015
Galanin receptors possibly modulate the obesity-induced change in pain threshold
resolves10.1155/2011/625315
An Examination of the Observed Placebo Effect Associated with the Treatment of Low Back Pain – A Systematic Review
resolves10.1016/S0140-6736(78)92762-9
THE MECHANISM OF PLACEBO ANALGESIA
resolves10.1073/pnas.1305050110
Placebo improves pleasure and pain through opposite modulation of sensory processing
resolves10.1523/JNEUROSCI.5791-10.2011
Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
resolves10.1016/j.pain.2013.02.005
Altered gray matter volume in the frontal pain modulation network in patients with cluster headache
resolves10.1111/papr.12181
Endogenous Pain Modulation in Response to Exercise in Patients with Rheumatoid Arthritis, Patients with Chronic Fatigue Syndrome and Comorbid Fibromyalgia, and Healthy Controls: A Double‐Blind Randomized Controlled Trial
resolves10.1016/j.neuroimage.2011.12.045
Acupuncture — Deep pain with an autonomic dimension?
resolves10.1016/0306-4522(93)90372-M
Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP
resolves10.1093/bja/aet153
Opioids and immune modulation: more questions than answers
resolves10.36076/ppj.2011/14/249
Peripherally Acting Opioids and Clinical Implications for Pain Control
resolves10.3389/fphar.2013.00123
Targeting pain and inflammation by peripherally acting opioids
resolves10.1124/jpet.113.208272
Modulation of Peripheral μ-Opioid Analgesia by σ1 Receptors
resolves10.1002/pam.21729
Point/Counterpoint
resolves10.1111/j.1476-5381.2010.01063.x
Non‐psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
resolves10.1186/1744-8069-6-16
Cannabinoid-Mediated Modulation of Neuropathic Pain and Microglial Accumulation in a Model of Murine Type I Diabetic Peripheral Neuropathic Pain
resolves10.1084/jem.20120242
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
resolves10.1016/j.pain.2012.11.007
Pain as a reward: Changing the meaning of pain from negative to positive co-activates opioid and cannabinoid systems
resolves10.1016/j.clinph.2013.04.001
Modulation of laser-evoked potentials and pain perception by transcutaneous electrical nerve stimulation (TENS): A placebo-controlled study in healthy volunteers
resolves10.1097/AJP.0b013e31823c2bd7
Functional Magnetic Resonance Imaging of the Effects of Low-frequency Transcutaneous Electrical Nerve Stimulation on Central Pain Modulation
resolves10.1002/j.1532-2149.2012.00208.x
High frequency electrical stimulation concurrently induces central sensitization and ipsilateral inhibitory pain modulation
resolves10.1111/j.1526-4610.2012.02141.x
tDCS‐Induced Analgesia and Electrical Fields in Pain‐Related Neural Networks in Chronic Migraine
resolves10.1097/AJP.0b013e318262330f
Alternating-Frequency TENS Effects on Experimental Pain in Healthy Human Participants
The 6 references without a DOI — listed, not checked
no DOI — not checkedIntrathecal lentivirus‐mediated transfer of interleukin‐10 attenuates chronic constriction injury‐induced neuropathic pain through modulation of spinal high‐mobility group box 1 in rats
no DOI — not checkede_1_2_18_9_1
no DOI — not checkedEndogenous opioid analgesia in peripheral tissues and the clinical implications for pain control
no DOI — not checkedHeart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children
no DOI — not checkedThe anti‐nociception effect of dezocine in a rat neuropathic pain model
no DOI — not checkedCholecystokinin enhances visceral pain‐related affective memory via vagal afferent pathway in rats
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