Reference health

The <scp>GAD65</scp> knock out mouse – a model for <scp>GABAergic</scp> processes in fear‐ and stress‐induced psychopathology

https://doi.org/10.1111/gbb.12188
CiteStamped reference-health badge
117/117 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 117 checked references that resolve
resolves10.1006/bbrc.1996.1898
Mice Lacking the 65 kDa Isoform of Glutamic Acid Decarboxylase (GAD65) Maintain Normal Levels of GAD67 and GABA in Their Brains but Are Susceptible to Seizures
resolves10.1073/pnas.94.12.6496
Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase
resolves10.1016/j.brainresbull.2005.09.015
Effects of early-life stress on behavior and neurosteroid levels in the rat hypothalamus and entorhinal cortex
resolves10.1016/j.nlm.2004.02.004
Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat
resolves10.1016/j.psyneuen.2008.12.018
Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor
resolves10.1016/j.bbr.2013.11.042
The GABA-synthetic enzyme GAD65 controls circadian activation of conditioned fear pathways
resolves10.1101/lm.705408
Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory
resolves10.1016/S0149-7634(01)00009-4
Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic
resolves10.1016/S0149-7634(96)00062-0
Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries
resolves10.1016/0091-3057(93)90185-V
Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice
resolves10.1523/JNEUROSCI.18-15-05938.1998
Region-Specific Regulation of Glutamic Acid Decarboxylase (GAD) mRNA Expression in Central Stress Circuits
resolves10.1016/0091-3057(86)90547-2
Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus
resolves10.1016/j.brainresbull.2007.06.003
GABA/benzodiazepine receptors in the ventromedial hypothalamic nucleus regulate both anxiety and panic-related defensive responses in the elevated T-maze
resolves10.1038/sj.npp.1300436
Maternal Behavior Regulates Benzodiazepine/GABAA Receptor Subunit Expression in Brain Regions Associated with Fear in BALB/c and C57BL/6 Mice
resolves10.1016/j.nlm.2007.07.009
Contextual learning induces an increase in the number of hippocampal CA1 neurons expressing high levels of BDNF☆
resolves10.1523/JNEUROSCI.22-13-05271.2002
Absence of Long-Term Depression in the Visual Cortex of Glutamic Acid Decarboxylase-65 Knock-Out Mice
resolves10.4088/JCP.12m07946
Childhood Sexual Abuse and Psychiatric Disorders in Middle-Aged and Older Adults
resolves10.1083/jcb.118.2.309
Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain.
resolves10.1016/S0021-9258(18)54529-4
Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.
resolves10.1038/12207
Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
resolves10.1176/appi.ajp.2011.11010052
Cortical Deficits of Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Clinical, Protein, and Cell Type-Specific Features
resolves10.1016/j.pnpbp.2013.05.006
Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers
resolves10.1016/j.psyneuen.2013.06.007
Enduring psychobiological effects of childhood adversity
resolves10.1007/s00213-010-1835-6
Sustained stress-induced changes in mice as a model for chronic depression
resolves10.1016/0896-6273(91)90077-D
Two genes encode distinct glutamate decarboxylases
resolves10.1007/978-1-4615-3302-3_10
The Midbrain Periaqueductal Gray as a Coordinator of Action in Response to Fear and Anxiety
resolves10.1007/s00213-010-1973-x
GABAA ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety
resolves10.1101/lm.183406
Stability of recent and remote contextual fear memory
resolves10.1111/j.1499-1654.2000.001534.x
Distribution of Seizure Precipitants Among Epilepsy Syndromes
resolves10.1016/j.biopsych.2009.02.027
Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1
resolves10.1016/j.expneurol.2011.07.009
Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice
resolves10.1016/j.brainres.2012.01.073
Post-weaning social isolation rearing influences the expression of molecules related to inhibitory neurotransmission and structural plasticity in the amygdala of adult rats
resolves10.1016/j.biopsych.2014.05.010
Lower Glutamic Acid Decarboxylase 65-kDa Isoform Messenger RNA and Protein Levels in the Prefrontal Cortex in Schizoaffective Disorder but Not Schizophrenia
resolves10.1016/j.neuron.2014.06.033
Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation
resolves10.1016/j.bbr.2012.12.001
Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice
resolves10.1001/archpsyc.57.11.1061
Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder
resolves10.1101/lm.993608
Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear
resolves10.1212/01.wnl.0000278112.48285.84
Seizure occurrence
resolves10.1038/sj.npp.1300468
Prepulse Inhibition Deficits in GAD65 Knockout Mice and the Effect of Antipsychotic Treatment
resolves10.1038/tp.2012.101
In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice
resolves10.1111/j.1460-9568.2007.05970.x
Training‐induced changes in the expression of GABA<sub>A</sub>‐associated genes in the amygdala after the acquisition and extinction of Pavlovian fear
resolves10.1126/science.282.5393.1504
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
resolves10.1038/sj.mp.4001845
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
resolves10.1159/000331393
Post-Weaning to Pre-Pubertal (‘Juvenile’) Stress: A Model of Induced Predisposition to Stress-Related Disorders
resolves10.1073/pnas.95.26.15718
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
resolves10.1523/JNEUROSCI.23-17-06695.2003
Rapid Critical Period Induction by Tonic Inhibition in Visual Cortex
resolves10.1016/S0168-0102(99)00005-X
Development of the GABA system in organotypic culture of hippocampal and cerebellar slices from a 67-kDa isoform of glutamic acid decarboxylase (GAD67)-deficient mice
resolves10.1016/j.neures.2005.12.008
Behavioural anomalies in mice evoked by “Tokyo” disruption of the Vitamin D receptor gene
resolves10.1073/pnas.94.25.14060
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
resolves10.1073/pnas.96.4.1698
Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
resolves10.1111/j.1471-4159.1991.tb08211.x
Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions
resolves10.1016/j.nlm.2013.04.005
Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: Dissociation between anxiety, locomotion and non-emotional memory behavior
resolves10.1038/npp.2014.72
Glutamic Acid Decarboxylase 65: A Link Between GABAergic Synaptic Plasticity in the Lateral Amygdala and Conditioned Fear Generalization
resolves10.1002/ajmg.b.30377
Mutation screen of the <i>GAD2</i> gene and association study of alcoholism in three populations
resolves10.1016/S0166-4328(03)00101-3
Generalisation of conditioned fear and its behavioural expression in mice
resolves10.1146/annurev.neuro.23.1.155
Emotion Circuits in the Brain
resolves10.1111/j.1601-183X.2009.00501.x
Heroin addiction in African Americans: a hypothesis‐driven association study
resolves10.1073/pnas.051614698
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse
resolves10.1016/j.pnpbp.2013.01.020
Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder
resolves10.1016/S0920-9964(01)00198-0
Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia
resolves10.1016/j.neuroscience.2012.11.037
Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress
resolves10.1038/29312
Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala
resolves10.1038/npp.2010.53
Behavioral and Neural Analysis of GABA in the Acquisition, Consolidation, Reconsolidation, and Extinction of Fear Memory
resolves10.1146/annurev.neuro.24.1.897
Neurobiology of Pavlovian Fear Conditioning
resolves10.1002/syn.10085
Gabaergic modulation of the stress response in frontal cortex and amygdala
resolves10.1523/JNEUROSCI.11-09-02725.1991
Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain
resolves10.1111/ejn.12337
Traits of fear resistance and susceptibility in an advanced intercross line
resolves10.1523/JNEUROSCI.23-09-03855.2003
Neural Correlates of Competing Fear Behaviors Evoked by an Innately Aversive Stimulus
resolves10.1038/sj.mp.4001939
Mechanisms of fear extinction
resolves10.1016/j.yebeh.2004.11.003
Which seizure-precipitating factors do patients with epilepsy most frequently report?
resolves10.1016/j.brainres.2006.05.007
Rats displaying distinct exploratory activity also have different expression patterns of γ-aminobutyric acid- and cholecystokinin-related genes in brain regions
resolves10.1097/FBP.0000000000000070
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression
resolves10.1016/j.bbr.2014.07.023
PCP-induced deficits in murine nest building activity: Employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia
resolves10.1016/0006-8993(94)01318-C
The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines
resolves10.1037/0735-7044.106.2.274
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
resolves10.1073/pnas.0801853105
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder
resolves10.1523/JNEUROSCI.0047-14.2014
Modulation of GABAA Receptor Signaling Increases Neurogenesis and Suppresses Anxiety through NFATc4
resolves10.1152/jn.1991.66.3.999
Inhibitory transmission in the basolateral amygdala
resolves10.1002/j.1460-2075.1991.tb08069.x
GABA and pancreatic beta‐cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic‐like microvesicles suggests their role in GABA storage and secretion.
resolves10.1093/schbul/sbs195
Prenatal Immune Activation Induces Maturation-Dependent Alterations in the Prefrontal GABAergic Transcriptome
resolves10.1016/S1734-1140(12)70955-6
Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice
resolves10.1016/S0014-2999(00)00128-X
Sodium lactate elicits anxiety in rats after repeated GABA receptor blockade in the basolateral amygdala
resolves10.1016/0006-8993(95)00915-D
Priming of experimental anxiety by repeated subthreshold GABA blockade in the rat amygdala
resolves10.1111/gbb.12131
Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice
resolves10.1101/lm.025874.112
Differential regulation of glutamic acid decarboxylase gene expression after extinction of a recent memory vs. intermediate memory
resolves10.1523/JNEUROSCI.2620-09.2009
Deficiency of the 65 kDa Isoform of Glutamic Acid Decarboxylase Impairs Extinction of Cued But Not Contextual Fear Memory
resolves10.1016/j.nlm.2008.06.007
Gabaergic mechanisms of hypothalamic nuclei in the expression of conditioned fear
resolves10.1523/JNEUROSCI.2161-13.2013
Hippocampal Hyperexcitability Underlies Enhanced Fear Memories in Tg<i>NTRK3</i>, a Panic Disorder Mouse Model
resolves10.1016/j.bbr.2012.05.016
Generalization of contextual fear depends on associative rather than non-associative memory components
resolves10.1038/npp.2013.81
Phencyclidine-Induced Social Withdrawal Results from Deficient Stimulation of Cannabinoid CB1 Receptors: Implications for Schizophrenia
resolves10.1016/j.euroneuro.2013.11.007
Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model
resolves10.1038/nn1732
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
resolves10.1046/j.1471-4159.1996.66052082.x
Heteromers of Glutamate Decarboxylase Isoforms Occur in Rat Cerebellum
resolves10.1016/S0197-0186(99)00063-7
Regional distribution and relative amounts of glutamate decarboxylase isoforms in rat and mouse brain
resolves10.1038/sj.mp.4002121
Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system
resolves10.1016/S0920-1211(99)00093-5
Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy
resolves10.1016/j.seizure.2007.09.003
Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy
resolves10.1016/S0006-8993(00)02206-X
Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65
resolves10.1034/j.1601-183X.2003.00008.x
Altered conditioned fear behavior in glutamate decarboxylase 65 null mutant mice
resolves10.1523/JNEUROSCI.20-23-08909.2000
Putative Cortical and Thalamic Inputs Elicit Convergent Excitation in a Population of GABAergic Interneurons of the Lateral Amygdala
resolves10.1073/pnas.96.22.12911
The role of the synthetic enzyme GAD65 in the control of neuronal γ-aminobutyric acid release
resolves10.1038/sj.npp.1301397
Exposure to Stressors during Juvenility Disrupts Development-Related Alterations in the PSA-NCAM to NCAM Expression Ratio: Potential Relevance for Mood and Anxiety Disorders
resolves10.1371/journal.pone.0094666
Long-Term Behavioral Programming Induced by Peripuberty Stress in Rats Is Accompanied by GABAergic-Related Alterations in the Amygdala
resolves10.1176/ajp.2006.163.8.1446
Relationship Between Posttrauma GABA Plasma Levels and PTSD at 1-Year Follow-Up
resolves10.1016/j.biopsych.2003.08.009
Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder
resolves10.1590/S0100-879X2003000500002
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear
resolves10.1001/archpsyc.57.3.237
Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia
resolves10.1037/0033-295X.104.4.667
Schizophrenia: A neural diathesis-stress model.
resolves10.1111/j.1471-4159.2010.07043.x
GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity
resolves10.1371/journal.pone.0037651
Gender Differences in Associations of Glutamate Decarboxylase 1 Gene (GAD1) Variants with Panic Disorder
resolves10.3171/2009.9.JNS09577
Induction of panic attack by stimulation of the ventromedial hypothalamus
resolves10.1172/JCI71472
Changes in neural network homeostasis trigger neuropsychiatric symptoms
resolves10.1016/j.brainres.2007.04.008
Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles—Evidence from GAD65-knockout mice studies
resolves10.1016/j.neuron.2007.09.006
Response Variation following Trauma: A Translational Neuroscience Approach to Understanding PTSD
resolves10.1016/j.schres.2007.02.023
Systematic study of association of four GABAergic genes: Glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABAB receptor 1 gene and GABAA receptor subunit β2 gene, with schizophrenia using a universal DNA microarray
resolves10.1097/WNR.0000000000000243
Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice
resolves10.1097/YCO.0b013e3282f269ee
Post-traumatic stress disorder: facts and fiction
The 1 reference without a DOI — listed, not checked
no DOI — not checkedGAD65 haplodeficiency conveys resilience in animal models of stress‐induced psychopathology
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

checked 2026-07-22 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record

Embed this badge

Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.

<a href="https://citestamp.com/citestamped/10.1111/gbb.12188"><img src="https://citestamp.com/citestamped/10.1111/gbb.12188/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>
[![CiteStamped reference-health badge](https://citestamp.com/citestamped/10.1111/gbb.12188/badge.svg)](https://citestamp.com/citestamped/10.1111/gbb.12188)