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Animal Models of Acute Moderate Hypoxia Are Associated with a Down-Regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and Up-Regulation of CYP3A6 and P-glycoprotein in Liver
38/38 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 38 checked references that resolve
resolves10.1016/S0026-895X(25)09857-8
Transforming growth factor-beta 1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture.
resolves10.1124/dmd.105.006197
THE ROLE OF PREGNANE X RECEPTOR IN 2-ACETYLAMINOFLUORENE-MEDIATED INDUCTION OF DRUG TRANSPORT AND -METABOLIZING ENZYMES IN MICE
resolves10.1074/jbc.M006180200
Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension
resolves10.1016/S0014-2999(03)01968-X
Interleukin-1β, interleukin-6, tumour necrosis factor-α and interferon-γ released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes
resolves10.1016/0003-2697(76)90527-3
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
resolves10.1515/BC.2005.060
A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression
resolves10.1074/jbc.274.17.12115
Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways
resolves10.1006/abbi.1996.9815
Identification of Positive and Negative Regulatory Elements of the Human Cytochrome P4501A2 (CYP1A2) Gene
resolves10.1158/0008-5472.CAN-04-1919
c-Jun NH2-Terminal Kinase Activation Contributes to Hypoxia-Inducible Factor 1α–Dependent P-Glycoprotein Expression in Hypoxia
resolves10.1002/cpt1976194468
The effect of arterial oxygen tension on antipyrine half‐time in plasma
resolves10.1038/sj.bjp.0701232
Down‐regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver
resolves10.1016/S0009-9236(96)90001-6
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*
resolves10.1038/sj.bjp.0704933
Hypoxia‐induced down‐regulation of CYP1A1/1A2 and up‐regulation of CYP3A6 involves serum mediators
resolves10.1038/sj.bjp.0705543
Hypoxia‐inducible factor‐1 and activator protein‐1 modulate the upregulation of CYP3A6 induced by hypoxia
resolves10.1016/1043-4666(93)90017-Y
Regulation of IL-6 and the hepatic IL-6 receptor in acute inflammation in vivo
resolves10.1007/s002280100268
Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine
resolves10.1111/j.1365-2125.1995.tb04455.x
Metabolism of theophylline by cDNA‐expressed human cytochromes P‐450.
resolves10.1006/abbi.2000.1772
Suppression of CYP2C11 Gene Transcription by Interleukin-1 Mediated by NF-κB Binding at the Transcription Start Site
resolves10.1124/dmd.32.1.20
SUPPRESSION OF DRUG-METABOLIZING ENZYMES AND EFFLUX TRANSPORTERS IN THE INTESTINE OF ENDOTOXIN-TREATED RATS
resolves10.1074/jbc.M313599200
The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme
resolves10.1038/sj.bjp.0702795
Effect of hypoxia alone or combined with inflammation and 3‐methylcholanthrene on hepatic cytochrome P450 in conscious rabbits
resolves10.1016/S0167-4889(00)00041-0
Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions
resolves10.1002/(SICI)1097-4652(199712)173:3<335::AID-JCP5>3.0.CO;2-O
Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells
resolves10.1038/bjc.1991.405
Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance
resolves10.1152/jappl.2000.88.4.1474
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
resolves10.1016/S0090-9556(25)07377-5
Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
resolves10.1007/s00280-006-0224-7
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1α gene
resolves10.1124/jpet.104.076141
The Involvement of the Pregnane X Receptor in Hepatic Gene Regulation during Inflammation in Mice
resolves10.1074/jbc.274.1.510
Ah Receptor and NF-κB Interactions, a Potential Mechanism for Dioxin Toxicity
resolves10.1016/S0168-8278(03)00238-1
Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA
resolves10.1074/jbc.272.19.12422
Activation of Transcription Factor NF-κB and p38 Mitogen-activated Protein Kinase Is Mediated by Distinct and Separate Stress Effector Pathways
The 2 references without a DOI — listed, not checked
no DOI — not checkedFactors affecting the expression and function of P-glycoprotein in rats: drug treatments and diseased states
no DOI — not checkedRegulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species
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