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1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel γ-Secretase Modulator, Reduces Brain β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease without Causing Peripheral Toxicity
40/40 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 40 checked references that resolve
resolves10.1212/01.wnl.0000260269.93245.d2
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
resolves10.1001/jama.289.21.2819
Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression
resolves10.1074/jbc.M404937200
Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site
resolves10.1124/jpet.106.114330
The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse
resolves10.1523/JNEUROSCI.3987-04.2004
Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide
resolves10.1124/jpet.106.103184
A Novel Phospholipid Derivative of Indomethacin, DP-155 [Mixture of 1-Steroyl and 1-Palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl Choline], Shows Superior Safety and Similar Efficacy in Reducing Brain Amyloid β in an Alzheimer’s Disease Model
resolves10.1172/JCI18162
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
resolves10.1016/j.neurobiolaging.2005.02.006
Nimodipine selectively stimulates β-amyloid 1–42 secretion by a mechanism independent of calcium influx blockage
resolves10.1073/pnas.1834302100
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
resolves10.1126/science.274.5284.99
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
resolves10.1523/JNEUROSCI.22-06-02246.2002
Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice
resolves10.1523/JNEUROSCI.21-02-00372.2001
Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease
resolves10.1124/jpet.104.073965
Lack of Specific Amyloid-β(1-42) Suppression by Nonsteroidal Anti-Inflammatory Drugs in Young, Plaque-Free Tg2576 Mice and in Guinea Pig Neuronal Cultures
resolves10.1523/JNEUROSCI.20-15-05709.2000
Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
resolves10.1016/S0197-4580(01)00299-8
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
resolves10.1038/nm1112
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
resolves10.1093/toxsci/kfh254
Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation
resolves10.1046/j.1471-4159.2002.01195.x
Selective inhibition of Aβ42 production by NSAID <i>R</i>‐enantiomers
resolves10.1021/jm0502541
Synthesis and Biological Activity of Flurbiprofen Analogues as Selective Inhibitors of β-Amyloid<sub>1</sub><sub>-</sub><sub>42</sub>Secretion
resolves10.1073/pnas.0503839103
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
resolves10.1074/jbc.M307757200
Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor
resolves10.1016/j.bmcl.2006.01.033
The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer’s disease modifying agent
resolves10.1016/S0002-9440(10)63269-5
Modulation of Nuclear Factor-κB Activity by Indomethacin Influences Aβ Levels but Not Aβ Precursor Protein Metabolism in a Model of Alzheimer's Disease
resolves10.1159/000078501
Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Alzheimer’s Disease: A Systematic Review
resolves10.1074/jbc.M301619200
Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation
resolves10.1038/sj.npp.1300690
A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment
resolves10.1038/nature03659
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
resolves10.1016/S0140-6736(01)05623-9
Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study
resolves10.1016/j.brainresrev.2004.12.026
Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology
resolves10.1038/35102591
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
resolves10.1074/jbc.M304824200
Aβ42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain
resolves10.1074/jbc.M303592200
Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity
resolves10.1016/j.neuroscience.2006.10.020
Amyloid-β vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
resolves10.1074/jbc.M311652200
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
resolves10.1523/JNEUROSCI.23-20-07504.2003
Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease
The 1 reference without a DOI — listed, not checked
no DOI — not checkedSainati SM, Ingram DM, Talwalker S, and Geis G (2000) Results of a double-blind, randomized, placebo-controlled study of celecoxib in the treatment of progression of Alzheimer’s disease, in 6th International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy; 2000 April 5–8; Stockholm, Sweden. Abstract Book, p 180.
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