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Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

https://doi.org/10.1126/sciadv.aax2659
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54/54 checkable references clean · checked 2026-07-25

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 54 checked references that resolve
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Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
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resolves10.1186/s13287-017-0628-9
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resolves10.1016/j.scr.2011.11.002
Aging alters tissue resident mesenchymal stem cell properties
resolves10.1073/pnas.062527199
Embryonic stem cells and somatic cells differ in mutation frequency and type
resolves10.1371/journal.pgen.1005932
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resolves10.1038/ncomms15183
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Mutagenesis by <i>O</i><sup>6</sup>-Methyl-, <i>O</i><sup>6</sup>-Ethyl-, and <i>O</i><sup>6</sup>-Benzylguanine and <i>O</i><sup>4</sup>-Methylthymine in Human Cells:  Effects of <i>O</i><sup>6</sup>-Alkylguanine-DNA Alkyltransferase and Mismatch Repair
resolves10.1093/mutage/geh025
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resolves10.1038/362709a0
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resolves10.1038/sj.bjc.6601894
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
resolves10.1101/322859
The Repertoire of Mutational Signatures in Human Cancer
resolves10.1038/ng.2653
The Genotype-Tissue Expression (GTEx) project
resolves10.1038/nature11245
Architecture of the human regulatory network derived from ENCODE data
resolves10.1146/annurev-genet-120213-092015
Transcription-Associated Mutagenesis
resolves10.1073/pnas.45.1.30
ON THE NATURE OF THE AGING PROCESS
resolves10.1111/j.1749-6632.1958.tb46828.x
THE AGING PROCESS AND CANCEROGENESIS
resolves10.1155/2011/859415
Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver
resolves10.1093/carcin/21.3.379
Significance of multiple mutations in cancer
resolves10.1016/j.cell.2017.09.004
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns
resolves10.1038/nature21065
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
resolves10.1126/science.aah4115
Aging increases cell-to-cell transcriptional variability upon immune stimulation
resolves10.1002/bit.10727
Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK)
resolves10.1016/S0070-2153(05)73005-2
Biological Principles for Ex Vivo Adult Stem Cell Expansion
resolves10.1634/stemcells.20-6-561
Asymmetric Cell Kinetics Genes: The Key to Expansion of Adult Stem Cells in Culture
resolves10.1038/nature11826
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
resolves10.1016/j.cell.2014.11.050
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
resolves10.1093/bioinformatics/btp324
Fast and accurate short read alignment with Burrows–Wheeler transform
resolves10.1093/bioinformatics/btp352
The Sequence Alignment/Map format and SAMtools
resolves10.1101/gr.107524.110
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
resolves10.1101/gr.129684.111
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
resolves10.1038/nbt.2514
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
resolves10.1002/hep.24252
Hepatocyte turnover and regeneration: Virtually a virtuoso performance
resolves10.1053/j.gastro.2009.05.044
Stem Cells and Liver Regeneration
resolves10.1186/s13073-018-0539-0
MutationalPatterns: comprehensive genome-wide analysis of mutational processes
resolves10.1093/nar/gkq603
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
resolves10.1093/nar/gkg509
SIFT: predicting amino acid changes that affect protein function
resolves10.1093/bioinformatics/btv195
PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels
resolves10.1038/nprot.2012.101
Identifying ChIP-seq enrichment using MACS
The 1 reference without a DOI — listed, not checked
no DOI — not checkedA. J. Sanyal T. D. Boyer N. A. Terrault K. D. Lindor Zakim and Boyer’s Hepathology: A Testbook Of Liver Disease (Elsevier ed. 7 2017).
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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