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Metabolic Regulation of Brain Aβ by Neprilysin
27/27 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
5 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 27 checked references that resolve
resolves10.1016/S0962-8924(98)01363-4
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
resolves10.1016/0166-2236(93)90008-A
Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease
resolves10.1016/S0197-4580(98)00033-5
Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid
resolves10.1038/72237
Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
resolves10.1074/jbc.274.45.32469
Molecular Identification and Characterization of Novel Membrane-bound Metalloprotease, the Soluble Secreted Form of Which Hydrolyzes a Variety of Vasoactive Peptides
resolves10.1073/pnas.070509897
Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers
resolves10.1093/oxfordjournals.jbchem.a022839
Biochemical Identification of the Neutral Endopeptidase Family Member Responsible for the Catabolism of Amyloid Peptide in the Brain
resolves10.1523/JNEUROSCI.20-05-01657.2000
Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme
resolves10.1023/A:1007527721160
Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains
resolves10.1523/JNEUROSCI.20-11-03937.2000
The Plasmin System Is Induced by and Degrades Amyloid-β Aggregates
resolves10.1016/S0896-6273(00)80230-5
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
resolves10.1046/j.1460-9568.1999.00698.x
Accumulation of murine amyloidβ42 in a gene‐dosage‐dependent manner in PS1 ‘knock‐in’ mice
resolves10.1016/S0304-3940(97)00660-5
Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice
resolves10.1016/S0304-3940(00)01675-X
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide
resolves10.1016/0896-6273(94)90458-8
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
resolves10.1074/jbc.270.11.5723
Tissue-specific Expression of Rat Neutral Endopeptidase (Neprilysin) mRNAs
resolves10.1006/bbrc.1995.1275
Characterization of the 5′ Region of the CD10/Neutral Endopeptidase 24.11 Gene
resolves10.1016/S0303-7207(00)00326-9
Identification and characterization of two androgen response regions in the human neutral endopeptidase gene
resolves10.1007/s004399900082
A familial case of Alzheimer's disease without tau pathology may be linked with chromosome 3 markers
The 5 references without a DOI — listed, not checked
no DOI — not checked___, Neurosci. News 5(3), 52 (2000).
no DOI — not checkedK. Shirotani et al. J. Biol. Chem. in press (available at www.jbc.org/cgi/reprint/M008511200v1).
no DOI — not checkedA. Perez L. Morelli
no DOI — not checkedN. Iwata et al. data not shown.
no DOI — not checkedWe thank T. Kudo and M. Takeda for providing mutant I213T presenilin 1 knock-in mice. We also thank T. Yoshikawa for valuable discussions; J. Q. Trojanowski V. M.-Y. Lee and T. Hensch for critical reading of the manuscript; and Y. Dohzono M. Sekiguchi E. Hosoki and K. Watanabe for technical assistance. Funded by research grants from RIKEN BSI Ministry of Education Special Coordination Funds for promoting Science and Technology of STA Ministry of Health and Welfare and Takeda Chemical Industries.
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