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Structure of Tracheal Cytotoxin in Complex with a Heterodimeric Pattern-Recognition Receptor

https://doi.org/10.1126/science.1123056
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18/18 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

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The 18 checked references that resolve
resolves10.1016/S0092-8674(00)80412-2
Innate Immunity: The Virtues of a Nonclonal System of Recognition
resolves10.1038/nature02021
The immune response of Drosophila
resolves10.1016/S1074-7613(04)00104-9
Monomeric and Polymeric Gram-Negative Peptidoglycan but Not Purified LPS Stimulate the Drosophila IMD Pathway
resolves10.1038/ni922
The Drosophila immune system detects bacteria through specific peptidoglycan recognition
resolves10.4049/jimmunol.173.12.7339
Peptidoglycan Molecular Requirements Allowing Detection by the <i>Drosophila</i> Immune Deficiency Pathway
resolves10.1073/pnas.97.25.13772
A family of peptidoglycan recognition proteins in the fruit fly <i>Drosophila melanogaster</i>
resolves10.1177/09680519050110020601
Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system
resolves10.1128/iai.36.2.782-794.1982
Detection, isolation, and analysis of a released Bordetella pertussis product toxic to cultured tracheal cells
resolves10.1073/pnas.0504547102
Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition
resolves10.1073/pnas.0407559102
Ligand-induced dimerization of <i>Drosophila</i> peptidoglycan recognition proteins <i>in vitro</i>
resolves10.1073/pnas.0407856101
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins
resolves10.1073/pnas.0404952102
<i>Drosophila</i> peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
resolves10.1371/journal.pbio.0020277
A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity
resolves10.1016/j.jmb.2005.01.070
Crystal Structure of Human Peptidoglycan Recognition Protein S (PGRP-S) at 1.70Å Resolution
resolves10.1016/j.jmb.2004.04.077
Crystal Structure of the Drosophila Peptidoglycan Recognition Protein (PGRP)-SA at 1.56 Å Resolution
resolves10.1038/ni952
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster
resolves10.1074/jbc.M001239200
Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth
resolves10.1074/jbc.M513030200
Structural Basis for Preferential Recognition of Diaminopimelic Acid-type Peptidoglycan by a Subset of Peptidoglycan Recognition Proteins
The 2 references without a DOI — listed, not checked
no DOI — not checkedMaterials and methods are available as supporting material on Science Online.
no DOI — not checkedWe thank K. Ihara and S. Wakatsuki for sharing their beamtime for screening crystals at the Photon Factory Japan and for helpful advice and technical assistance. This work was supported by the Howard Hughes Medical Institute (to J.D.) and the Centre National de la Recherche Scientifique (to D.M.-L.). Coordinates and structural factors have been submitted to the Protein Data Bank (PDB) with accession number 2F2L.
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