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Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants

https://doi.org/10.1128/jcm.00921-21
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18/18 checkable references clean · checked 2026-07-25

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

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The 18 checked references that resolve
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Molecular Epidemiology Surveillance of SARS-CoV-2: Mutations and Genetic Diversity One Year after Emerging
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Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity
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Genetic Variants of SARS-CoV-2—What Do They Mean?
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SARS-CoV-2 Viral Variants—Tackling a Moving Target
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COVID-19: A review of therapeutic strategies and vaccine candidates
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A Review of the Progress and Challenges of Developing a Vaccine for COVID-19
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
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Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
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Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape
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The immunodominant and neutralization linear epitopes for SARS-CoV-2
resolves10.1001/jama.2021.1612
Emergence of a Novel SARS-CoV-2 Variant in Southern California
resolves10.1126/science.abg5458
Captive gorillas test positive for coronavirus
resolves10.1016/j.cell.2020.07.012
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity
resolves10.1016/j.cell.2021.04.025
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
resolves10.1126/science.abi7994
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
resolves10.1016/j.chom.2021.06.006
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
resolves10.1016/j.jmb.2020.07.009
Mutations Strengthened SARS-CoV-2 Infectivity
resolves10.3389/fimmu.2021.691715
Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
The 1 reference without a DOI — listed, not checked
no DOI — not checkedWHO. 2021. Weekly epidemiological update on COVID-19 – 15 June 2021. WHO Emergency Situational Updates. WHO, Geneva, Switzerland.
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