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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
36/36 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 36 checked references that resolve
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Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
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Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial
resolves10.1172/JCI21404
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
resolves10.1053/j.gastro.2007.03.104
Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice
resolves10.1084/jem.20061082
IL-23 plays a key role in
<i>Helicobacter hepaticus</i>
–induced T cell–dependent colitis
resolves10.1038/ni.1736
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
resolves10.4049/jimmunol.177.5.2760
Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis
resolves10.1016/j.clim.2003.09.013
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
resolves10.1126/science.1135245
A Genome-Wide Association Study Identifies
<i>IL23R</i>
as an Inflammatory Bowel Disease Gene
resolves10.1038/ng2061
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
resolves10.1038/ng.175
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
resolves10.1053/j.gastro.2008.07.014
A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease
resolves10.1126/scitranslmed.3001107
Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
resolves10.1136/gut.2005.081950b
European evidence based consensus on the diagnosis and management of Crohn’s disease: current management
resolves10.1038/ng2032
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
resolves10.1053/j.gastro.2005.11.030
Human Anti–Tumor Necrosis Factor Monoclonal Antibody (Adalimumab) in Crohn’s Disease: the CLASSIC-I Trial
resolves10.1053/gast.2001.24042
An engineered human antibody to TNF (CDP571) for active Crohn's disease: A randomized double-blind placebo-controlled trial
resolves10.7326/0003-4819-146-12-200706190-00159
Adalimumab Induction Therapy for Crohn Disease Previously Treated with Infliximab
resolves10.1111/j.1365-2036.2004.02285.x
Intravenous CDP870, a PEGylated Fab′ fragment of a humanized antitumour necrosis factor antibody, in patients with moderate‐to‐severe Crohn's disease: an exploratory study
resolves10.1097/MOG.0b013e328339d099
Proinflammatory cytokines underlying the inflammation of Crohnʼs disease
resolves10.1002/acr.20420
Submissions invited for themed issue of <i>Arthritis Care & Research</i>: Muscle and bone in the rheumatic diseases
resolves10.1084/jem.20091983
Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
resolves10.1126/science.1200439
Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
resolves10.1084/jem.20110958
Gain-of-function human
<i>STAT1</i>
mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
resolves10.1016/S1473-3099(11)70217-1
Insights into human antifungal immunity from primary immunodeficiencies
resolves10.1038/ajg.2009.454
Relationship of C-Reactive Protein With Clinical Response After Therapy With Ustekinumab in Crohn's Disease
resolves10.1038/ajg.2008.36
TNFSF15 Polymorphisms Are Associated With Susceptibility to Inflammatory Bowel Disease in a New European Cohort
resolves10.1002/ibd.21124
TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease
The 3 references without a DOI — listed, not checked
no DOI — not checkedSpiegelhalter D Abrams KR Myles JP . Bayesian Approaches to Clinical Trials and Health-care Evaluation. Chichester, UK: John Wiley & Sons, 2004. ISBN:978-0-471-49975-6.
no DOI — not checkedRich PA Sigurgeirsson B Thaci PD . Secukinumab, A New Fully Human Monoclonal Anti-Interleukin-17A Antibody, in the Treatment of Moderate-to-severe Plaque Psoriasis: Interim Efficacy and Safety Data from a Phase II Regimen-finding Trial. 20th Congress of the European Academy of Dermatology and Venereology; October 21, 2011. Lisbon, Portugal. Abstract 0627. ISBN# 9789892026091.
no DOI — not checkedA Multicentre, Randomized, Double-blind, Placebo-controlled Phase 2b Study of Ustekinumab, A Human Monoclonal Antibody to IL-12/23p40 in Patients with Moderately to Severely Active Crohn's Disease: Results Through Week 22 from the CERTIFI trial DDW 2011
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