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Protein transport into the human ER and related diseases, Sec61-channelopathies

https://doi.org/10.1139/bcb-2014-0043

141/141 checkable references clean · checked 2026-07-22

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The 141 checked references that resolve

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ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum

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A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

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Structural Determinants of Lateral Gate Opening in the Protein Translocon

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Regulation of the Protein-Conducting Channel by a Bound Ribosome

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Immunoglobulin heavy chain binding protein

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A new role for BiP

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Following the signal sequence from ribosomal tunnel exit to signal recognition particle

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The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER Membrane

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BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

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Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

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Evolutionary conservation of components of the protein translocation complex

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Ca2+-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane

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MAM: more than just a housekeeper

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TRAM Regulates the Exposure of Nascent Secretory Proteins to the Cytosol during Translocation into the Endoplasmic Reticulum

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Structure of the SecY Complex Unlocked by a Preprotein Mimic

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TRC40 can deliver short secretory proteins to the Sec61 translocon

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The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

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Genomic and Expression Analysis of the 3q25-q26 Amplification Unit Reveals TLOC1/SEC62 as a Probable Target Gene in Prostate Cancer

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Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

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Sec61 complexes form ubiquitous ER Ca2+leak channels

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Both Lumenal and Cytosolic Gating of the Aqueous ER Translocon Pore Are Regulated from Inside the Ribosome during Membrane Protein Integration

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Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

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A Point Mutation in Sec61α1 Leads to Diabetes and Hepatosteatosis in Mice

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Basal and Physiological Ca2+ Leak from the Endoplasmic Reticulum of Pancreatic Acinar Cells

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A new congenital disorder of glycosylation caused by a mutation in SSR4, the signal sequence receptor 4 protein of the TRAP complex

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Glioblastoma Proto-oncogene SEC61γ Is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress

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The Unfolding Tale of the Unfolded Protein Response

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Intricate Links between ER Stress and Apoptosis

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The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer

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Mammalian Sec61 Is Associated with Sec62 and Sec63

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Different Transmembrane Domains Associate with Distinct Endoplasmic Reticulum Components during Membrane Integration of a Polytopic Protein

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Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

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A membrane component essential for vectorial translocation of nascent proteins across the endoplasmic reticulum: requirements for its extraction and reassociation with the membrane.

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Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum.

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Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

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Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation

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The mystery of nonclassical protein secretion

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Mechanisms of regulated unconventional protein secretion

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The Mammalian Endoplasmic Reticulum-Associated Degradation System

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Intracellular Ca2+ release via the ER translocon activates store-operated calcium entry

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Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor

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Intracellular Aspects of the Process of Protein Synthesis

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Preserving the membrane barrier for small molecules during bacterial protein translocation

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Structure of the SecY channel during initiation of protein translocation

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Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

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Structure and 3D Arrangement of Endoplasmic Reticulum Membrane-Associated Ribosomes

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Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

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Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

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Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

resolves10.1074/jbc.M202559200

Endoplasmic Reticulum-bound Ribosomes Reside in Stable Association with the Translocon following Termination of Protein Synthesis

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Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane

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Biogenesis of tail-anchored proteins: the beginning for the end?

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Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation

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Myopathy in Marinesco–Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology

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The Role of p58IPK in Protecting the Stressed Endoplasmic Reticulum

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The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

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Sec61p is part of the endoplasmic reticulum‐associated degradation machinery

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BiP‐mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

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A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.

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Control of glycosylation of MHC class II‐associated invariant chain by translocon‐associated RAMP4

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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

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Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy

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A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

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Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase

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A protein-conducting channel in the endoplasmic reticulum

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Large aqueous channels in membrane vesicles derived from the rough endoplasmic reticulum of canine pancreas or the plasma membrane of Escherichia coli.

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TRAP assists membrane protein topogenesis at the mammalian ER membrane

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

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The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast

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Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes

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Polypeptide‐binding proteins mediate completion of co‐translational protein translocation into the mammalian endoplasmic reticulum

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Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores

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X-ray structure of a protein-conducting channel

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

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Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane.

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A protein complex required for signal-sequence-specific sorting and translocation

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Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation

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Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7

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Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP

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Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

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Seventy‐kilodalton heat shock proteins and an additional component from reticulocyte lysate stimulate import of M13 procoat protein into microsomes.

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