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Prognostic Effect of Epithelial and Stromal Lymphocyte Infiltration in Non–Small Cell Lung Cancer

https://doi.org/10.1158/1078-0432.ccr-08-0133
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36/36 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

8 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 36 checked references that resolve
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Prognosis of 6644 resected non-small cell lung cancers in Japan: A Japanese lung cancer registry study
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CD4<sup>+</sup>CD25<sup>high</sup> regulatory T cells reduce T cell transendothelial migration in cancer patients
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CD4<sup>+</sup> T cells in cancer stroma, not CD8<sup>+</sup> T cells in cancer cell nests, are associated with favorable prognosis in human non‐small cell lung cancers
resolves10.1067/mlc.2002.128317
Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression
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Tumour‐infiltrating lymphocytes in non‐small cell lung cancer are activated T lymphocytes
resolves10.1158/1078-0432.CCR-0732-3
Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma
resolves10.1002/jso.10321
Prognostic value of intratumoral CD8<sup>+</sup> T lymphocyte in extrahepatic bile duct carcinoma as essential immune response
resolves10.1073/pnas.0611618104
CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma
resolves10.1177/205873920601900117
Tumor Infiltrating Lymphocytes in Uveal Melanoma: A Link with Clinical Behavior?
resolves10.1158/1078-0432.CCR-06-1734
CD8+ T-Cell Content in Diagnostic Lymph Nodes Measured by Flow Cytometry Is a Predictor of Survival in Follicular Lymphoma
resolves10.1111/j.1600-0463.2001.apm090706.x
High number of tumour-infiltrating lymphocytes is associated with apoptosis in non-small cell lung carcinoma
resolves10.1038/sj.bjc.6602934
Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma
resolves10.1016/S0169-5002(02)00100-9
Immunologic parameters as significant prognostic factors in lung cancer
resolves10.1016/j.jss.2003.11.006
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Tissue microarray technology for high-throughput molecular profiling of cancer
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Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
resolves10.1158/1078-0432.CCR-07-0414
Inverse Prognostic Impact of Angiogenic Marker Expression in Tumor Cells versus Stromal Cells in Non–Small Cell Lung Cancer
resolves10.1038/ni1102-991
Cancer immunoediting: from immunosurveillance to tumor escape
resolves10.1056/NEJMp058236
Tumor-Infiltrating T Cells — Friend or Foe of Neoplastic Cells?
resolves10.1016/j.lungcan.2003.11.004
Immune activation status of CD8+ T cells infiltrating non-small cell lung cancer
resolves10.1007/s00262-006-0214-y
Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma
resolves10.1111/j.1349-7006.2007.00558.x
HLA class I antigen expression is associated with a favorable prognosis in early stage non‐small cell lung cancer
resolves10.1038/sj.bjc.6602201
Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis
resolves10.1002/1521-4141(200208)32:8<2199::AID-IMMU2199>3.0.CO;2-L
CD8 lethargy in the absence of CD4 help
resolves10.1084/jem.186.12.2057
CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity
resolves10.1038/nri1413
Helping the CD8+ T-cell response
resolves10.1002/eji.200324181
CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
resolves10.1084/jem.194.6.823
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
resolves10.1158/1078-0432.CCR-05-1886
Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers
resolves10.1016/j.molmed.2005.03.002
Immunotherapy: target the stroma to hit the tumor
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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
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The promise of cancer vaccines
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De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
The 8 references without a DOI — listed, not checked
no DOI — not checkedParkin DM, Muir CS. Cancer incidence in five continents. Comparability and quality of data. IARC Sci Publ 1992;120:45–173.
no DOI — not checkedMukai S, Kjaergaard J, Shu S, Plautz GE. Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy. Cancer Res 1999;59:5245–9.
no DOI — not checkedCostello RT, Gastaut JA, Olive D. Tumor escape from immune surveillance. Arch Immunol Ther Exp (Warsz) 1999;47:83–8.
no DOI — not checkedEerola AK, Soini Y, Paakko P. A high number of tumor-infiltrating lymphocytes are associated with a small tumor size, low tumor stage, and a favorable prognosis in operated small cell lung carcinoma. Clin Cancer Res 2000;6:1875–81.
no DOI — not checkedSchumacher K, Haensch W, Roefzaad C, Schlag PM. Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. Cancer Res 2001;61:3932–6.
no DOI — not checkedNaito Y, Saito K, Shiiba K, et al. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 1998;58:3491–4.
no DOI — not checkedPelletier MP, Edwardes MD, Michel RP, Halwani F, Morin JE. Prognostic markers in resectable non-small cell lung cancer: a multivariate analysis. Can J Surg 2001;44:180–8.
no DOI — not checkedSpiotto MT, Schreiber H. Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells. Cancer Immun 2005;5:8.
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