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PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer

https://doi.org/10.1158/1078-0432.ccr-12-2623
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1 of 44 checkable references need attention · checked 2026-07-23

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

4 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

References needing attention

does not resolve to a known work10.1302/0301-620X.82B2 .9730
The 43 checked references that resolve
resolves10.1053/j.gastro.2007.08.001
Histologic Inflammation Is a Risk Factor for Progression to Colorectal Neoplasia in Ulcerative Colitis: A Cohort Study
resolves10.1038/nri1132
The immunological and genetic basis of inflammatory bowel disease
resolves10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z
Cancer risk in patients with inflammatory bowel disease
resolves10.1053/j.gastro.2010.05.037
Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis
resolves10.1053/j.gastro.2009.12.001
Phosphatidylinositol 3-Kinase γ Inhibition Ameliorates Inflammation and Tumor Growth in a Model of Colitis-Associated Cancer
resolves10.1126/science.1096502
High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers
resolves10.1016/S0092-8674(00)81683-9
The Hallmarks of Cancer
resolves10.1097/01.sla.0000220040.66012.a9
Targeted Molecular Therapy of the PI3K Pathway
resolves10.1158/0008-5472.CAN-05-2612
Breast Cancer–Associated <i>PIK3CA</i> Mutations Are Oncogenic in Mammary Epithelial Cells
resolves10.1038/nrc1753
Oncogenic PI3K deregulates transcription and translation
resolves10.1007/s10555-011-9286-z
The significant role of mast cells in cancer
resolves10.1016/j.it.2008.07.004
The multiple roles of phosphoinositide 3-kinase in mast cell biology
resolves10.1016/j.ccr.2011.04.016
Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
resolves10.18632/oncotarget.240
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
resolves10.1016/S0021-9258(17)37680-9
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
resolves10.1073/pnas.0913683107
In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction
resolves10.1158/1078-0432.CCR-09-1230
Crosstalk between Mast Cells and Pancreatic Cancer Cells Contributes to Pancreatic Tumor Progression
resolves10.1073/pnas.0704620104
Mast cells are an essential hematopoietic component for polyp development
resolves10.1182/blood.V75.5.1037.1037
Structure and function of the leukocyte adhesion molecules CD11/CD18
resolves10.1111/j.1365-2141.1995.tb05195.x
Flow cytometric analysis of intracellular CD6 8 molecule expression in normal and malignant haemopoiesis
resolves10.1371/journal.pone.0002916
Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth
resolves10.1158/0008-5472.CAN-10-1923
Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APCΔ468 Mice
resolves10.1007/s12307-010-0052-5
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
resolves10.1038/nm1649
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
resolves10.1016/S0145-2126(02)00343-0
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI
resolves10.1016/j.bcmd.2005.08.006
Uncommon phenotypes of acute myelogenous leukemia: Basophilic, mast cell, eosinophilic, and myeloid dendritic cell subtypes: A review
resolves10.1053/j.gastro.2010.01.058
Inflammation and Colon Cancer
resolves10.1038/nri2340
The genetics and immunopathogenesis of inflammatory bowel disease
resolves10.1016/S0016-5085(19)35241-2
Carcinoma and Ulcerative Colitis: Prognosis
resolves10.1016/j.ejca.2005.04.022
The prevalence of PIK3CA mutations in gastric and colon cancer
resolves10.1053/j.gastro.2009.10.038
Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis
resolves10.1007/BF02071410
Increased numbers of macrophages in noninflamed gastroduodenal mucosa of patients with Crohn's disease
resolves10.1078/0065-1281-00641
Mast cells and inflammatory mediators in chronic ulcerative colitis
resolves10.1158/1078-0432.CCR-06-2073
High Macrophage Infiltration along the Tumor Front Correlates with Improved Survival in Colon Cancer
resolves10.1186/1479-5876-9-88
No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients
resolves10.1016/j.dld.2004.09.028
Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas
resolves10.1182/blood-2006-12-062448
CD34 facilitates the development of allergic asthma
resolves10.1189/jlb.0704386
Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation
resolves10.3748/wjg.v11.i8.1210
Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer
resolves10.1074/jbc.M009851200
Phosphoinositide 3-Kinase Facilitates Antigen-stimulated Ca2+ Influx in RBL-2H3 Mast Cells via a Phosphatidylinositol 3,4,5-Trisphosphate-sensitive Ca2+Entry Mechanism
resolves10.1038/ni768
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice
resolves10.1111/j.1440-1746.2007.05009.x
Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer
resolves10.1016/j.cell.2010.03.014
Macrophage Diversity Enhances Tumor Progression and Metastasis
The 4 references without a DOI — listed, not checked
no DOI — not checkedMast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation
no DOI — not checkedThe phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
no DOI — not checkedWortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
no DOI — not checkedPrognostic significance of microvessel density and mast cell density for the survival of Thai patients with primary colorectal cancer
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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