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Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

https://doi.org/10.1158/1078-0432.ccr-21-2547
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24/24 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 24 checked references that resolve
resolves10.1093/annonc/mdf172
End points for new agents in induction chemotherapy for locally advanced head and neck cancers
resolves10.1093/annonc/mdq453
Optimal treatment for recurrent/metastatic head and neck cancer
resolves10.3389/fcell.2019.00052
Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy
resolves10.1056/NEJMoa0912217
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
resolves10.1093/jnci/djn011
Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial
resolves10.1016/S0140-6736(19)32591-7
Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study
resolves10.3389/fonc.2020.00268
Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer
resolves10.1158/0008-5472.CAN-15-1490
Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment
resolves10.1593/neo.11980
Modeling Pharmacological Inhibition of Mast Cell Degranulation as a Therapy for Insulinoma
resolves10.1158/2159-8290.CD-15-0827
Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
resolves10.1158/0008-5472.CAN-14-2852
Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma
resolves10.1038/s41389-021-00308-z
Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness
resolves10.1016/j.celrep.2017.03.037
Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis
resolves10.1016/bs.mie.2019.05.039
High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers
resolves10.1016/j.idc.2019.01.001
Chemotherapy and Beyond
resolves10.1073/pnas.1119238109
Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response
resolves10.1371/journal.ppat.1003446
Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages
resolves10.1038/s41408-018-0136-x
Effect of the BTK inhibitor ibrutinib on macrophage- and γδ T cell-mediated response against Mycobacterium tuberculosis
resolves10.1186/s40425-017-0257-y
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
resolves10.1158/2326-6066.CIR-16-0237
Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients
resolves10.1111/liv.13746
Hepatotoxicity of immune checkpoint inhibitors: An evolving picture of risk associated with a vital class of immunotherapy agents
resolves10.1172/JCI89756
Ibrutinib treatment improves T cell number and function in CLL patients
resolves10.1158/0008-5472.CAN-14-3098
Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer
resolves10.1038/sj.bjc.6605465
Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
The 2 references without a DOI — listed, not checked
no DOI — not checkedHead and neck squamous cell carcinoma
no DOI — not checked2025112606400543300_bib14
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