Reference health
S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure
2 of 42 checkable references need attention · checked 2026-07-23
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
does not resolve to a known work10.1172/JCI18004
does not resolve to a known work10.1172/JCI14172
The 40 checked references that resolve
resolves10.1172/JCI10905
Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
resolves10.1074/jbc.M403937200
The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis
resolves10.1006/bbrc.1999.1586
Sphingosine 1-Phosphate Induces Angiogenesis: Its Angiogenic Action and Signaling Mechanism in Human Umbilical Vein Endothelial Cells
resolves10.1016/S0092-8674(00)81661-X
Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate
resolves10.1038/nm.3934
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure
resolves10.1074/jbc.M008375200
Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase
resolves10.1172/jci.insight.85484
Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload
resolves10.1016/S0014-2999(03)01731-X
S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate
resolves10.1038/sj.bjp.0707581
Analysis of sphingosine 1‐phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools
resolves10.1124/jpet.103.062828
Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes
resolves10.1016/j.ahj.2014.06.028
Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications
resolves10.1038/nature02284
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
resolves10.1126/science.1070238
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
resolves10.1177/1352458509357065
Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
resolves10.1182/blood-2003-02-0460
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
resolves10.1016/j.devcel.2012.07.015
Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development
resolves10.1111/j.1476-5381.2009.00451.x
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
resolves10.1074/jbc.M610318200
Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor
resolves10.1016/S1474-4422(14)70049-3
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial
resolves10.1371/journal.pone.0052985
The Clinically-tested S1P Receptor Agonists, FTY720 and BAF312, Demonstrate Subtype-Specific Bradycardia (S1P1) and Hypertension (S1P3) in Rat
resolves10.1111/j.1476-5381.2012.01865.x
FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase
resolves10.1161/CIRCRESAHA.107.165845
Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
resolves10.1038/nm1338
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice
resolves10.1242/jcs.02541
Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells
resolves10.1038/nature03952
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
resolves10.1161/CIRCRESAHA.108.192765
Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades
resolves10.1146/annurev.bioeng.9.060906.151959
The Structure and Function of the Endothelial Glycocalyx Layer
resolves10.1172/JCI81067
P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction
resolves10.1114/1.1397792
Modulation of ATP/ADP Concentration at the Endothelial Surface by Shear Stress: Effect of Flow-Induced ATP Release
resolves10.1172/JCI40659
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
resolves10.1161/CIRCRESAHA.110.226464
Sphingosine-1-Phosphate–Dependent Activation of p38 MAPK Maintains Elevated Peripheral Resistance in Heart Failure Through Increased Myogenic Vasoconstriction
resolves10.1161/01.CIR.0000080324.12530.0D
Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase
resolves10.1161/CIRCRESAHA.108.173575
Role of Sphingosine-1-Phosphate Phosphohydrolase 1 in the Regulation of Resistance Artery Tone
The 2 references without a DOI — listed, not checked
no DOI — not checkedWorld Health Organization. Global Status Report on Noncommunicable Diseases 2010. Geneva: World Health Organization; 2011.
no DOI — not checkedRubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol. 1986;250(6 pt 2):H1145–H1149.
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