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mTOR has distinct functions in generating versus sustaining humoral immunity
55/55 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
1 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 55 checked references that resolve
resolves10.1016/j.immuni.2009.01.011
Initial Clonal Expansion of Germinal Center B Cells Takes Place at the Perimeter of Follicles
resolves10.1084/jem.173.5.1165
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
resolves10.1084/jem.192.6.813
Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival
resolves10.1182/blood-2009-01-200014
The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells
resolves10.4049/jimmunol.1102808
Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens
resolves10.4049/jimmunol.1100783
Long-Term Maintenance of Polysaccharide-Specific Antibodies by IgM-Secreting Cells
resolves10.1084/jem.173.3.731
Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.
resolves10.1084/jem.171.1.265
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
resolves10.1084/jem.20092712
Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity
resolves10.1042/BST20130030
The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis
resolves10.1016/j.molcel.2006.03.029
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
resolves10.4049/jimmunol.1103143
Mammalian Target of Rapamycin Integrates Diverse Inputs To Guide the Outcome of Antigen Recognition in T Cells
resolves10.1038/ni.2005
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
resolves10.1093/ndt/gfn216
Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice
resolves10.1177/0961203307088289
Rapamycin prevents the development of nephritis in lupus-prone NZB/W F
<sub>1</sub>
mice
resolves10.1038/nrrheum.2015.172
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases
resolves10.1182/blood-2013-01-477505
Requirement for Rictor in homeostasis and function of mature B lymphoid cells
resolves10.1038/ni.2741
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus
resolves10.1073/pnas.1407104111
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition
resolves10.1002/eji.201040677
Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling
resolves10.1084/jem.20040168
Short-lived Plasmablasts and Long-lived Plasma Cells Contribute to Chronic Humoral Autoimmunity in NZB/W Mice
resolves10.4049/jimmunol.1401264
Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
resolves10.1126/science.1213368
B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity
resolves10.4049/jimmunol.1501365
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells
resolves10.1016/j.cell.2010.10.032
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
resolves10.1084/jem.20040973
Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
resolves10.1016/j.molcel.2010.06.022
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
resolves10.1128/MCB.24.15.6773-6787.2004
Global mRNA Stabilization Preferentially Linked to Translational Repression during the Endoplasmic Reticulum Stress Response
resolves10.1016/j.immuni.2015.10.021
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones
resolves10.1002/eji.1830211209
Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens
resolves10.1038/ni.3348
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
resolves10.1002/art.27233
Efficacy and safety of rituximab in moderately‐to‐severely active systemic lupus erythematosus: The randomized, double‐blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial
resolves10.1371/journal.pone.0135081
Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice
resolves10.1126/scitranslmed.3006941
Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression
resolves10.2202/1544-6115.1027
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
The 1 reference without a DOI — listed, not checked
no DOI — not checkedLong-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
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