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Pancreatic Beta-cell Dysfunction in Type 2 Diabetes
137/137 checkable references clean · checked 2026-08-10
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 137 checked references that resolve
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ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells
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BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells
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Celebrities in the heart, strangers in the pancreatic beta cell: Voltage‐gated potassium channels K<sub>v</sub>7.1 and K<sub>v</sub>11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes
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KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current
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Patients With Long-QT Syndrome Caused by Impaired
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KCNQ1 Long QT Syndrome Patients Have Hyperinsulinemia and Symptomatic Hypoglycemia
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Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
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Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: Role of free fatty acid receptor 2
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Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes
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DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis
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Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating Autophagy
resolves10.1007/s00125-022-05842-y
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
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Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis
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Exploring G Protein-Coupled Receptor Signaling in Primary Pancreatic Islets
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The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent
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Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion and prevents glucotoxicity-induced β-cell dysfunction
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Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
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The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
resolves10.1371/journal.pone.0226696
N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells
resolves10.3390/nu11091979
Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid
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∆nFGF1 Protects <i>β</i>‐Cells against High Glucose‐Induced Apoptosis via the AMPK/SIRT1/PGC‐1<i>α</i> Axis
resolves10.1021/acschembio.2c00052
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
resolves10.1016/j.molcel.2021.08.027
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity
resolves10.3389/fendo.2018.00384
Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes
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Mechanisms controlling pancreatic islet cell function in insulin secretion
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Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis
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Free fatty acid receptors in the endocrine regulation of glucose metabolism: Insight from gastrointestinal-pancreatic-adipose interactions
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A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion.
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Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.
resolves10.1080/19382014.2019.1601490
Palmitate is not an effective fuel for pancreatic islets and amplifies insulin secretion independent of calcium release from endoplasmic reticulum
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Toxicity of fatty acid profiles of popular edible oils in human EndoC-βH1 beta-cells
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Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-βH1 beta-cells
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Palmitate Inhibits Insulin Gene Expression by Altering PDX-1 Nuclear Localization and Reducing MafA Expression in Isolated Rat Islets of Langerhans
resolves10.1186/1476-511X-10-115
Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells
resolves10.1186/s12986-021-00541-8
Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death
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Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells
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Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice
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Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells
resolves10.1002/dmrr.1233
Interleukin‐6 treatment induces beta‐cell apoptosis via STAT‐3‐mediated nitric oxide production
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Micro<scp>RNA</scp>‐181c negatively regulates the inflammatory response in oxygen‐glucose‐deprived microglia by targeting Toll‐like receptor 4
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Upregulation of caveolin-1 and its colocalization with cytokine receptors contributes to beta cell apoptosis
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Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
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Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice
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Islet Amyloid in Patients With Diabetes Due to Exocrine Pancreatic Disorders, Type 2 Diabetes, and Nondiabetic Patients
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Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
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Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.
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Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling
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Coordination of Zn
<sup>2+</sup>
and Cu
<sup>2+</sup>
to the membrane disrupting fragment of amylin
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Elemental composition of secretory granules in pancreatic islets of Langerhans
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Interaction of amylin species with transition metals and membranes
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Zinc Chelator Inhibits Zinc-Induced Islet Amyloid Polypeptide Deposition and Apoptosis in INS-1 Cells
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α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice
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Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein
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α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
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The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic β cells in type 2 diabetes
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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells
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Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic <i>β</i>-cells
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Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
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RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
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Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death
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Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β‐cells
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Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway
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Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
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Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
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Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity
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Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
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Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes
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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
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Identification of natural products with neuronal and metabolic benefits through autophagy induction
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ER Stress and β-Cell Pathogenesis of Type 1 and Type 2 Diabetes and Islet Transplantation
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The endoplasmic reticulum: structure, function and response to cellular signaling
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A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
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Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation
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Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress
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Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress
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Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cells
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Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload
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Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells
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Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells
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no DOI — not checkedPancreapedia: Exocrine Pancreas Knowledge Base
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no DOI — not checkedbibr132-1721727X231154152
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