Reference health
Deadly allies: the fatal interplay between platelets and metastasizing cancer cells
90/90 checkable references clean · checked 2026-07-25
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
16 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 90 checked references that resolve
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The Risk of a Diagnosis of Cancer after Primary Deep Venous Thrombosis or Pulmonary Embolism
resolves10.1016/j.ygyno.2006.05.034
The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma
resolves10.1002/1097-0142(19920615)69:12<2975::AID-CNCR2820691218>3.0.CO;2-A
Poor prognosis associated with thrombocytosis in patients with cervical cancer
resolves10.1016/S0002-9378(94)70225-X
Significance of thrombocytosis in patients with epithelial ovarian cancer
resolves10.1007/BF02573067
Poor prognosis associated with thrombocytosis in patients with gastric cancer
resolves10.1016/j.jamcollsurg.2004.01.022
Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma1
resolves10.1016/S0002-9343(99)80013-8
Elevated Plasma Thrombopoietic Activity in Patients With Metastatic Cancer-Related Thrombocytosis
resolves10.1172/JCI113411
Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo.
resolves10.1182/blood-2004-06-2272
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells
resolves10.1158/0008-5472.CAN-04-2078
Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation
resolves10.1158/0008-5472.CAN-09-2123
Platelet-Derived Transforming Growth Factor-β Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity
resolves10.1016/S0049-3848(01)00285-7
Molecular Basis for the Relationship Between Thrombosis and Cancer
resolves10.1073/pnas.94.2.663
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
resolves10.1016/j.ccr.2006.10.002
Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype
resolves10.1158/0008-5472.CAN-08-0718
Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage
resolves10.1111/j.1538-7836.2005.01770.x
Increased metastatic potential of tumor cells in von Willebrand factor‐deficient mice
resolves10.1084/jem.192.2.193
Platelet Glycoprotein Ibα Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)
resolves10.1084/jem.190.6.803
The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
resolves10.1016/0049-3848(95)00113-6
Characterization of tumor-induced platelet aggregation: The role of immunorelated GPIb and expression by MCF-7 breast cancer cells
resolves10.1038/sj.bjp.0705606
Membrane type‐1 matrix metalloproteinase stimulates tumour cell‐induced platelet aggregation: role of receptor glycoproteins
resolves10.1182/blood.V95.3.886.003k45_886_893
Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies
resolves10.1002/ijc.2910390617
Tumor‐cell‐induced platelet aggregation is a glycoprotein‐dependent and lipoxygenase‐associated process
resolves10.3181/00379727-186-3-RC1
Inhibition of Human Tumor Cell Induced Platelet Aggregation by Antibodies to Platelet Glycoproteins lb and llb/llla
resolves10.1182/blood-2004-03-1127
Genetic deletion of mouse platelet glycoprotein Ibβ produces a Bernard-Soulier phenotype with increased α-granule size
resolves10.1182/blood-2002-03-0997
Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome
resolves10.1016/S0301-472X(02)00774-9
Absence of GPIbα is responsible for aberrant membrane development during megakaryocyte maturation
resolves10.1158/0008-5472.CAN-03-1054
Endothelial P-Selectin as a Target of Heparin Action in Experimental Melanoma Lung Metastasis
resolves10.1016/S0092-8674(00)81607-4
Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow
resolves10.1182/blood-2004-04-1257
Integrins: dynamic scaffolds for adhesion and signaling in platelets
resolves10.1093/emboj/20.9.2120
Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen
resolves10.1016/j.thromres.2005.08.001
GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism
resolves10.1593/neo.08380
Type I Collagen Receptor (α2β1) Signaling Promotes Prostate Cancer Invasion through RhoC GTPase
resolves10.1080/09537109975915
Blockade of GpIIb/IIIa inhibits the release of vascular endothelial growth factor (VEGF) from tumor cell-activated platelets and experimental metastasis
resolves10.1002/(SICI)1097-0045(19980515)35:3<185::AID-PROS4>3.0.CO;2-G
Role of αIIbβ3 integrin in prostate cancer metastasis
resolves10.1002/(SICI)1097-0215(19970807)72:4<642::AID-IJC16>3.0.CO;2-D
Ectopic expression of platelet integrin αIIbβ3 in tumor cells from various species and histological origin
resolves10.1038/13522
Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice
resolves10.1111/j.1432-1033.1994.tb18647.x
Two human melanoma cell‐line variants with enhanced <i>in vivo</i> tumor growth and metastatic capacity do not express the β<sub>3</sub> integrin subunit
resolves10.1002/jcb.21709
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice
resolves10.1152/physrev.1999.79.1.181
Mechanisms That Regulate the Function of the Selectins and Their Ligands
resolves10.1055/s-0037-1614407
The Biology of P-Selectin Glycoprotein Ligand-1: Its Role as a Selectin Counterreceptor in Leukocyte-Endothelial and Leukocyte-Platelet Interaction
resolves10.1038/359848a0
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
resolves10.1084/jem.20021868
Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin
resolves10.1073/pnas.261704098
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis
resolves10.1073/pnas.061615598
Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
resolves10.1016/S0049-3848(07)70138-X
Heparin attenuates metastasis mainly due to inhibition of P- and L-selectin, but non-anticoagulant heparins can have additional effects
resolves10.1038/nature05816
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins
resolves10.1038/216857a0
Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets
resolves10.1073/pnas.72.8.2994
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
resolves10.1038/35393
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
resolves10.1016/0092-8674(91)90261-V
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
resolves10.1172/JCI6042
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
resolves10.1172/JCI114976
Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo.
resolves10.1073/pnas.92.18.8205
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.
resolves10.1182/blood.V92.10.3694
Protease-Activated Receptor 1 (PAR-1) Is Required and Rate-Limiting for Thrombin-Enhanced Experimental Pulmonary Metastasis
resolves10.1016/0049-3848(92)90081-K
Thrombin enhances tumor cell adhesive and metastatic properties via increased αIIbβ3 expression on the cell surface
resolves10.1046/j.1365-2141.1996.d01-1494.x
Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumour tyrosine phosphorylation
resolves10.1002/ijc.2910530620
Thrombin stimulates melanoma tumor‐cell binding to endothelial cells and subendothelial matrix
resolves10.1038/bjc.1998.349
Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under flow conditions: role of platelet glycoproteins P-selectin and GPIIb-IIIA
resolves10.1007/s11626-997-0139-6
Addition of both platelets and thrombin in combination accelerates tumor cells to adhere to endothelial cells In vitro
resolves10.1182/blood-2004-02-0434
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
resolves10.1002/1097-0142(19940701)74:1<38::AID-CNCR2820740108>3.0.CO;2-E
Subcutaneous heparin treatment increases survival in small cell lung cancer
resolves10.1158/1078-0432.CCR-05-1131
Differential Metastasis Inhibition by Clinically Relevant Levels of Heparins—Correlation with Selectin Inhibition, Not Antithrombotic Activity
resolves10.1160/TH05-07-0515
The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivo
resolves10.1200/JCO.2005.03.133
Randomized Comparison of Low Molecular Weight Heparin and Coumarin Derivatives on the Survival of Patients With Cancer and Venous Thromboembolism
resolves10.1111/j.1538-7836.2004.00871.x
A randomized clinical trial of combination chemotherapy with and without low‐molecular‐weight heparin in small cell lung cancer
resolves10.1200/JCO.2004.10.002
Low Molecular Weight Heparin, Therapy With Dalteparin, and Survival in Advanced Cancer: The Fragmin Advanced Malignancy Outcome Study (FAMOUS)
resolves10.1200/JCO.2005.03.134
The Effect of Low Molecular Weight Heparin on Survival in Patients With Advanced Malignancy
resolves10.4065/81.6.758
Low-Molecular-Weight Heparin in Patients With Advanced Cancer: A Phase 3 Clinical Trial
resolves10.1186/1471-2407-9-355
FRAGMATIC: A randomised phase III clinical trial investigating the effect of fragmin® added to standard therapy in patients with lung cancer
The 16 references without a DOI — listed, not checked
no DOI — not checkedPhlegmasia alba dolens.
no DOI — not checkedThrombocytosis: platelet kinetics in neoplasia.
no DOI — not checkedPreoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer.
no DOI — not checkedThe role of tumor-induced platelet aggregation, platelet adhesion and adhesive proteins in tumor metastasis.
no DOI — not checkedInhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454.
no DOI — not checkedLysis of tumor cells by natural killer cells in mice is impeded by platelets.
no DOI — not checkedA mitogenic factor for transformed fibroblasts from human platelets.
no DOI — not checkedThe vascular biology of the glycoprotein Ib-IX-V complex.
no DOI — not checkedMultiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis.
no DOI — not checkedInhibition of in vive tumour growth by the blocking of host alpha (v) beta3 and alphaII(b) beta3 integrins.
no DOI — not checkedDifferential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins.
no DOI — not checkedIncreased expression of sialyl Lewis x antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study.
no DOI — not checkedTissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells.
no DOI — not checkedStimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.
no DOI — not checkedThe use of heparin for treating human malignancies.
no DOI — not checkedClinical studies with anticoagulants to improve survival in cancer patients.
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