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The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

https://doi.org/10.1182/blood-2013-03-493924
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21/21 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

3 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 21 checked references that resolve
resolves10.1182/blood.V96.8.2655
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1
resolves10.1182/blood-2004-03-0889
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α
resolves10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y
Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
resolves10.1038/leu.2008.299
CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
resolves10.1080/10428190290011921
Chemokine Receptors and Stromal Cells in the Homing and Homeostasis of Chronic Lymphocytic Leukemia B Cells
resolves10.1182/blood-2012-08-447813
Impact of oxygen concentration on growth of mesenchymal stromal cells from the marrow of patients with chronic lymphocytic leukemia
resolves10.1074/jbc.274.34.23916
Stromal Cell-derived Factor-1α Associates with Heparan Sulfates through the First β-Strand of the Chemokine
resolves10.1093/glycob/cwr052
Molecular modeling of the interaction between heparan sulfate and cellular growth factors: Bringing pieces together
resolves10.1161/CIRCULATIONAHA.112.113290
Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions
resolves10.1182/blood.V91.7.2387
Chronic Lymphocytic Leukemic B Cells But Not Normal B Cells Are Rescued From Apoptosis by Contact With Normal Bone Marrow Stromal Cells
resolves10.1182/blood-2009-07-233718
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
resolves10.1182/blood.V94.11.3658
Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells
resolves10.1073/pnas.91.6.2305
Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
resolves10.1182/blood-2004-12-4918
Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
resolves10.1371/journal.pone.0011716
Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomics Analysis
resolves10.1182/blood.V116.21.2450.2450
Preliminary Results From A Phase I Dose Escalation Study to Determine the Maximum Tolerated Dose of Plerixafor In Combination with Rituximab In Patients with Relapsed Chronic Lymphocytic Leukemia
resolves10.1517/13543784.2012.656197
Development of novel CXCR4-based therapeutics
resolves10.1038/nbt0996-1112
Mirror-image RNA that binds D-adenosine
resolves10.1002/cbic.200300663
Spiegelmers: Biostable Aptamers
resolves10.1038/clpt.2013.58
Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12
resolves10.1002/0471142700.nc0446s46
RNA Aptamers and Spiegelmers: Synthesis, Purification, and Post‐Synthetic PEG Conjugation
The 3 references without a DOI — listed, not checked
no DOI — not checkedMouse lymphoid leukemias: symbiotic complexes of neoplastic lymphocytes and their microenvironments.
no DOI — not checkedToward third-generation aptamers: Spiegelmers and their therapeutic prospects.
no DOI — not checkedPhase IIa study of the anti-CXCL12/SDF-1 Spiegelmer® Nox-A12 alone and combined with bendamustine/rituximab in patients with relapsed chronic lymphocytic leukemia (CLL) [abstract].
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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