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A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

https://doi.org/10.1182/blood-2014-02-555169
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70/70 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

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The 70 checked references that resolve
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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.
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CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
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The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression
resolves10.1182/blood-2003-09-3109
Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
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Six color flow cytometry detects plasma cells expressing aberrant immunophenotype in bone marrow of healthy donors
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Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells
resolves10.1182/blood-2008-04-153544
Blood-borne human plasma cells in steady state are derived from mucosal immune responses
resolves10.4049/jimmunol.1000911
Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells
resolves10.1182/blood-2010-01-266536
Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab
resolves10.1007/BF01468720
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Immunoglobulin Synthesis by Human Lymphoid Tissues: Normal Bone Marrow as a Major Site of IgG Production
resolves10.1182/blood-2004-07-2507
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resolves10.1002/eji.1830270319
Regulatory role of CD95 ligation on human B cells induced <i>in vivo</i> capable of spontaneous and highrate Ig secretion
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The Endoplasmic Reticulum Is a Key Component of the Plasma Cell Death Pathway
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TRAIL/Apo-2 Ligand Induces Primary Plasma Cell Apoptosis
resolves10.1073/pnas.88.19.8661
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.
resolves10.1038/ni.2527
Mcl-1 is essential for the survival of plasma cells
resolves10.1186/ar2789
Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis
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Polyclonal Rabbit Antithymocyte Globulin Triggers B-Cell and Plasma Cell Apoptosis by Multiple Pathways
resolves10.1158/0008-5472.CAN-06-2258
Extensive Immunoglobulin Production Sensitizes Myeloma Cells for Proteasome Inhibition
resolves10.4049/jimmunol.169.3.1277
Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a Memory Immune Response
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Plasma Cell Survival Is Mediated by Synergistic Effects of Cytokines and Adhesion-Dependent Signals
resolves10.1038/nm917
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Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cells
resolves10.1084/jem.20040973
Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
resolves10.4049/jimmunol.138.12.4128
Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells.
resolves10.1016/j.immuni.2006.01.012
Gene Repression by Pax5 in B Cells Is Essential for Blood Cell Homeostasis and Is Reversed in Plasma Cells
resolves10.4049/jimmunol.1102728
<i>CD28</i> –B7 Interaction Modulates Short- and Long-Lived Plasma Cell Function
resolves10.1084/jem.20110040
Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells
resolves10.1007/978-1-4614-6217-0_8
The CD28/B7 Pathway: A Novel Regulator of Plasma Cell Function
resolves10.4049/jimmunol.1100016
CD28 Expressed on Malignant Plasma Cells Induces a Prosurvival and Immunosuppressive Microenvironment
resolves10.4049/jimmunol.169.8.4213
The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity
resolves10.1002/eji.201344313
Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells
resolves10.4049/jimmunol.1002319
Basophils Support the Survival of Plasma Cells in Mice
resolves10.1038/ni.1981
Eosinophils are required for the maintenance of plasma cells in the bone marrow
resolves10.1182/blood-2009-12-259457
Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow
resolves10.1016/S0002-9440(10)62556-4
Expression of CD56/Neural Cell Adhesion Molecule Correlates with the Presence of Lytic Bone Lesions in Multiple Myeloma and Distinguishes Myeloma from Monoclonal Gammopathy of Undetermined Significance and Lymphomas with Plasmacytoid Differentiation
resolves10.1182/blood.V86.8.3151.3151
Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin
resolves10.3324/haematol.13740
Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
resolves10.1089/scd.2008.0212
Comparative Characteristics of Mesenchymal Stem Cells from Human Bone Marrow and Placenta: CD10, CD49d, and CD56 Make a Difference
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Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression
resolves10.1080/10428190500272549
Prognostic relevance of CD56 expression in multiple myeloma: A study including 107 cases treated with high-dose melphalan-based chemotherapy and autologous stem cell transplant
resolves10.1182/blood-2008-07-166892
Mesenchymal stromal cell–derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction
resolves10.1073/pnas.0800555105
Maintenance of the plasma cell pool is independent of memory B cells
resolves10.1002/art.22967
Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment
resolves10.1002/art.11181
Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis
resolves10.1016/j.clim.2006.08.016
Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE
resolves10.1084/jem.20071555
Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+ B cell repertoire in infants
resolves10.1084/jem.180.4.1383
Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.
resolves10.1084/jem.20101352
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
resolves10.1073/pnas.1113395108
Differential regulation of self-reactivity discriminates between IgG <sup>+</sup> human circulating memory B cells and bone marrow plasma cells
resolves10.1084/jem.20061254
High affinity germinal center B cells are actively selected into the plasma cell compartment
resolves10.1182/blood-2005-06-2269
Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin
resolves10.1038/nm1763
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
resolves10.1038/nrrheum.2009.184
CD19: a promising B cell target for rheumatoid arthritis
resolves10.1186/ar3909
Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity
resolves10.1182/blood.V76.2.377.377
Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19)
resolves10.1182/blood-2006-06-029355
CD200 is a new prognostic factor in multiple myeloma
resolves10.1309/AJCP59UORCYZEVQO
Diagnostic Usefulness and Prognostic Impact of CD200 Expression in Lymphoid Malignancies and Plasma Cell Myeloma
The 1 reference without a DOI — listed, not checked
no DOI — not checkedThe bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.
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