Reference health
Mitochondrial reactive oxygen species and cancer
1 of 110 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
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References needing attention
marked retracted — notice via Crossref, record curated by Retraction Watch10.1038/nature10167
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
The 109 checked references that resolve
resolves10.1126/science.270.5234.296
Requirement for Generation of H
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O
<sub>2</sub>
for Platelet-Derived Growth Factor Signal Transduction
resolves10.1126/scisignal.2002943
From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate
resolves10.1124/pr.110.002980
NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair
resolves10.1126/science.275.5306.1649
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
resolves10.7554/eLife.03496
Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress
resolves10.1016/j.freeradbiomed.2012.08.015
Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters
resolves10.1074/jbc.M407715200
Complex III Releases Superoxide to Both Sides of the Inner Mitochondrial Membrane
resolves10.1042/BJ20091541
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
resolves10.1016/j.cell.2010.01.009
Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling
resolves10.1074/jbc.M305770200
Glutathione Peroxidase 1 Is Regulated by the c-Abl and Arg Tyrosine Kinases
resolves10.1093/nar/gkq212
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
resolves10.1073/pnas.172398899
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
resolves10.1128/MCB.23.22.8137-8151.2003
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
resolves10.1074/jbc.M109.051714
Activation of NRF2 by Nitrosative Agents and H2O2 Involves KEAP1 Disulfide Formation
resolves10.1038/nature10189
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
resolves10.1158/0008-5472.CAN-12-4499
Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
resolves10.1038/nature01819
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
resolves10.1126/science.1069004
Redox Regulation of Forkhead Proteins Through a
<i>p66shc</i>
-Dependent Signaling Pathway
resolves10.1074/jbc.M410690200
Mitochondrial H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation
resolves10.1083/jcb.200512100
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism
resolves10.1016/S0006-291X(02)00268-1
Regulation of protein phosphatase 2A by hydrogen peroxide and glutathionylation
resolves10.1038/nature01680
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
resolves10.1111/j.1742-4658.2007.06173.x
Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells
resolves10.1016/j.molcel.2008.04.009
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
resolves10.1073/pnas.95.20.11715
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
resolves10.1016/S0014-5793(99)00783-8
Cells depleted of mitochondrial DNA (p<sup>0</sup>) yield insight into physiological mechanisms
resolves10.1074/jbc.M001914200
Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
resolves10.1161/CIRCRESAHA.109.206334
Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells
resolves10.1016/j.cmet.2005.05.001
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
resolves10.1016/j.cmet.2005.05.002
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
resolves10.1016/j.cmet.2005.05.003
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
resolves10.1083/jcb.200609074
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
resolves10.1016/j.cell.2004.08.025
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress
resolves10.1016/j.febslet.2005.03.088
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α
resolves10.1073/pnas.0706585104
A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation
resolves10.1073/pnas.0812688106
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma
resolves10.1016/j.cmet.2006.02.002
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
resolves10.1016/j.cmet.2011.10.008
Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity
resolves10.1038/onc.2010.193
Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression
resolves10.1016/j.cmet.2009.08.015
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2
resolves10.1016/j.ccr.2012.05.016
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
resolves10.1126/scisignal.2000431
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
resolves10.1126/science.1211485
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
resolves10.1016/j.cell.2013.09.025
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
resolves10.1073/pnas.1003428107
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
resolves10.1016/S1097-2765(02)00520-8
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
resolves10.1016/S1097-2765(02)00522-1
E2F1 and c-Myc Potentiate Apoptosis through Inhibition of NF-κB Activity that Facilitates MnSOD-Mediated ROS Elimination
resolves10.1016/j.cell.2012.04.026
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
resolves10.1016/j.ccr.2011.02.014
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
resolves10.1038/onc.2011.37
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
resolves10.1093/hmg/ddp069
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
resolves10.1093/hmg/ddr395
Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation
resolves10.1126/science.1156906
ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis
resolves10.1038/nature13110
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
resolves10.1093/hmg/ddt533
Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment
resolves10.1016/j.ajpath.2011.10.003
Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Mice
resolves10.1038/nrc3648
Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity
resolves10.1128/MCB.01338-07
Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis
resolves10.1158/0008-5472.203.65.1
A Mutation in the <i>SDHC</i> Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis
resolves10.1128/MCB.00483-09
Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
resolves10.1016/j.molcel.2013.05.003
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
resolves10.1016/j.ccr.2011.09.006
Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
resolves10.1016/j.ccr.2011.08.024
An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
resolves10.1056/NEJM199605023341802
Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease
resolves10.1016/j.immuni.2012.10.020
Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
resolves10.1186/1471-2407-13-285
Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death
resolves10.1371/journal.pone.0033411
Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis
resolves10.1074/jbc.275.1.223
Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I
resolves10.1042/bj3480607
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
resolves10.7554/eLife.02242
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
resolves10.1038/sj.onc.1209406
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells
resolves10.1126/scitranslmed.3003016
Anti-Invasive Adjuvant Therapy with Imipramine Blue Enhances Chemotherapeutic Efficacy Against Glioma
resolves10.1177/1534735404270335
Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness
resolves10.1016/j.ccr.2006.08.009
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
The 3 references without a DOI — listed, not checked
no DOI — not checkedSzatrowski TP, Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Can Res. 1991, 51 (3): 794-798.
no DOI — not checkedBuetler TM, Krauskopf A, Ruegg UT: Role of superoxide as a signaling molecule. News Physiol Sci. 2004, 19: 120-123.
no DOI — not checkedBhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL: Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest. 2009, 119 (8): 2359-2365.
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