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Effectiveness of modified Buzhong Yiqi decoction in treating myasthenia gravis: study protocol for a series of N-of-1 trials

https://doi.org/10.1186/s13063-022-06287-9
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30/30 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

11 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 30 checked references that resolve
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The epidemiology of myasthenia gravis
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Antibody effector mechanisms in myasthenia gravis—Pathogenesis at the neuromuscular junction
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Phenotypical characterization of regulatory T cells in humans and rodents
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Roles of cytokines and T cells in the pathogenesis of myasthenia gravis
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Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations
resolves10.1016/j.phrs.2019.02.024
Gut microbiota, a new frontier to understand traditional Chinese medicines
resolves10.3389/fmicb.2018.02627
Altered Gut Microbiota in Myasthenia Gravis
resolves10.1002/advs.201901441
Perturbed Microbial Ecology in Myasthenia Gravis: Evidence from the Gut Microbiome and Fecal Metabolome
resolves10.1155/2017/6512572
Efficacy and Safety of the TCM Qi‐Supplementing Therapy in Patients with Myasthenia Gravis: A Systematic Review and Meta‐Analysis
resolves10.1097/MD.0000000000013677
Modified Buzhong Yiqi decoction for myasthenia gravis
resolves10.1097/MD.0000000000023679
Therapeutic efficacy and immunoregulatory effect of Qiangji Jianli Capsule for patients with myasthenia gravis
resolves10.1021/acs.jcim.5b00449
Discovering New Acetylcholinesterase Inhibitors by Mining the <i>Buzhongyiqi</i> Decoction Recipe Data
resolves10.1038/ncomms16130
Correction: Corrigendum: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
resolves10.3389/fmicb.2017.02146
Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota
resolves10.1177/0962280217726801
Sample size considerations for <i>n</i> -of-1 trials
resolves10.1155/2018/5813767
Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N‐of‐1 Trials
resolves10.1007/s12561-016-9165-9
N-of-1 Design and Its Applications to Personalized Treatment Studies
resolves10.1016/j.ctim.2019.08.014
CONSORT extension for reporting N-of-1 trials for traditional Chinese medicine (CENT for TCM) : Recommendations, explanation and elaboration
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CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement
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Myasthenia gravis
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&lt;p&gt;Effect of the Short-Term Use of Fluoroquinolone and β-Lactam Antibiotics on Mouse Gut Microbiota&lt;/p&gt;
resolves10.1111/j.1749-6632.1998.tb11015.x
Reliability Testing of the Quantitative Myasthenia Gravis Score<sup>a</sup>
resolves10.1016/j.jclinepi.2010.04.020
Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations
resolves10.1016/S0895-4356(96)00429-5
Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment
resolves10.1002/0470092602
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resolves10.3233/NRE-161386
A series of n-of-1 trials of stimulants in brain injured children
resolves10.1155/2021/9976770
A Series of N-of-1 Trials for Traditional Chinese Medicine Using a Bayesian Method: Study Rationale and Protocol
resolves10.1016/j.jclinepi.2015.09.020
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The 11 references without a DOI — listed, not checked
no DOI — not checkedXinyan L, Lei F. Effects of Buzhong Yiqi Decoction on Treg Lymphocyte, Lymphocyte Subsets and on the Curative Effects of Elderly Patients with Myasthenia Gravis. World Chin Med. 2020;15(21):3336–9.
no DOI — not checkedHuang YY. ntegrated traditional Chinese and Western medicine in the treatment of 18 cases of myasthenia gravis. Henan Trad Chin Med. 2014;34:2432–3.
no DOI — not checkedZu LH. Effective observation on treating myasthenia gravis with the Buzhong Yiqi decoction plus hormone. Clin J Chin Med. 2015:28–76.
no DOI — not checkedQi G, Gu S, Liu P, Yang H, Dong H. Effects of combined traditional Chinese medicine with immunosuppressive agents for patients with myasthenia gravis. Int J Clin Exp Med. 2015;8(10):19044–50.
no DOI — not checkedOCEBM, Levels of Evidence Working Group. The Oxford Levels of Evidence 2. Oxford: Oxford Centre for Evidence-Based, Medicine; 2011.
no DOI — not checkedLi J, Wei D, Niu J, Yang M, Ge L, Wang X, et al. Potential Facilitators and Barriers to Awareness of N-of-1 Trials for Physicians in Traditional Chinese Medicine. Altern Ther Health Med. 2018;24(2):44–9.
no DOI — not checkedTing C. The Chinese guidelines for the diagnosis and treatment of myasthenia gravis (2020). Chin J Neuroimmunol Neurol. 2021;28(01):1–12.
no DOI — not checkedChina Association of Chinese Medicine. The guidelines for clinical diagnosis and treatment of internal medicine of traditional Chinese Medicine [M]. In: China Press of Traditional Chinese Medicine; 2020.
no DOI — not checkedWenfeng Z."Diagnosis standards for common syndromes in traditional Chinese medicine". J Hunan Univercity Chin Med. 2008(05):3–8+20. [in Chinese]
no DOI — not checkedEdwards LK. Applied Analysis of Variance in Behavioral Science. M. Dekker. 1993:297–344.
no DOI — not checkedZucker D, Ruthazer R, Schmid C, Feuer J, Fischer P, Kieval R, et al. Lessons learned combining N-of-1 trials to assess fibromyalgia therapies. J Rheumatol. 2006;33(10):2069–77.
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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