Reference health
Cardiotoxicity of 5‐fluorouracil and capecitabine in Chinese patients: a prospective study
6 of 29 checkable references need attention · checked 2026-07-23
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
does not resolve to a known work10.1007/s00432‐007‐0250‐9
does not resolve to a known work10.1007/s00280‐005‐0178‐1
does not resolve to a known work10.1016/0167‐8140(88)90296‐4
does not resolve to a known work10.1002/1097‐0142(19931001)72:7<2242::AID‐CNCR2820720730>3.0.CO;2‐E
does not resolve to a known work10.1007/s12094‐012‐0843‐x
does not resolve to a known work10.2165/00003495‐199855030‐00012
The 23 checked references that resolve
resolves10.1200/JCO.1998.16.1.301
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. Meta-analysis Group In Cancer.
resolves10.1200/JCO.2001.19.8.2282
Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Treatment in 605 Patients With Metastatic Colorectal Cancer: Results of a Randomized Phase III Study
resolves10.1159/000331645
Clinical and Electrocardiography Changes in Patients Treated with Capecitabine
resolves10.1016/j.ctrv.2013.03.005
Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: A systematic review of incidence, manifestations and predisposing factors
resolves10.1200/JCO.1989.7.4.509
Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study.
resolves10.1080/1120009X.1990.11739029
Cardiotoxicity During Chemotherapy Treatment with 5-Fluorouracil and Cisplatin
resolves10.1161/01.CIR.82.4.1296
Pathophysiology of silent myocardial ischemia during daily life. Hemodynamic evaluation by simultaneous electrocardiographic and blood pressure monitoring.
resolves10.1159/000227226
Symptomatic Cardiotoxicity with High-Dose 5-Fluorouracil Infusion: A Prospective Study
resolves10.1093/annonc/mdf108
Incidence of cardiotoxicity with the oral fluoropyrimidine capecitabine is typical of that reported with 5-fluorouracil
resolves10.1016/j.clcc.2012.09.003
Alternative Treatment Options in Colorectal Cancer Patients With 5–Fluorouracil- or Capecitabine-Induced Cardiotoxicity
resolves10.1038/sj.bjc.6601224
Plasma concentrations of 5-fluorouracil and F-β-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil
resolves10.1093/annonc/mdt479
Final results of Australasian Gastrointestinal Trials Group ARCTIC study: an audit of raltitrexed for patients with cardiac toxicity induced by fluoropyrimidines
resolves10.1016/j.ejca.2013.03.004
Use of raltitrexed as an alternative to 5-fluorouracil and capecitabine in cancer patients with cardiac history
resolves10.1023/A:1008369629944
Open label, multi-centre phase II study of raltitrexed (‘Tomudex’) in patients with inoperable squamous-cell carcinoma of head and neck
resolves10.1097/CAD.0000000000000371
Raltitrexed plus oxaliplatin-based transarterial chemoembolization in patients with unresectable hepatocellular carcinoma
resolves10.1093/annonc/mds236
ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
resolves10.1200/JCO.20005.14.589
Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma: An Intergroup Study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada
resolves10.1093/oxfordjournals.annonc.a010800
Final results of a randomised trial comparing ‘Tomudex’® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer
resolves10.1200/JCO.1998.16.9.2943
Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group.
The 6 references without a DOI — listed, not checked
no DOI — not checkedCardinale D, Colombo A, Lamantia G, Colombo N, Civelli M, De Giacomi G, et al. Cardio‐oncology: a new medical issue. Ecancermedicalscience. 2008; 2: 1263234071
no DOI — not checkedTsavaris N, Kosmas C, Vadiaka M, Efremidis M, Zinelis A, Beldecos D, et al. Cardiotoxicity following different doses and schedules of 5‐fluorouracil administration for malignancy—a survey of 427 patients. Med Sci Monit. 2002; 8 (6): PI51–PI57.
no DOI — not checkedKhan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A. A retrospective study of cardiotoxicities induced by 5‐fluouracil (5‐FU) and 5‐FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 2012; 62 (5): 430–434.
no DOI — not checkedMosseri M, Fingert HJ, Varticovski L, Chokshi S, Isner JM. In vitro evidence that myocardial ischemia resulting from 5‐fluorouracil chemotherapy is due to protein kinase C‐mediated vasoconstriction of vascular smooth muscle. Cancer Res. 1993; 53 (13): 3028–3033.
no DOI — not checkedPorta C, Moroni M, Ferrari S, Nastasi G. Endothelin‐1 and 5‐fluorouracil‐induced cardiotoxicity. Neoplasma. 1998; 45 (2): 81–82.
no DOI — not checkedNational Institute for Health and Care Excellence (NICE) : Managing advanced and metastatic colorectal cancer. 2017. https://pathways.nice.org.uk/pathways/colorectal‐cancer/managing‐advanced‐and‐metastatic‐colorectal‐cancer. Accessed 27 Mar 2018
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work were clean at the dated check: each resolved to a known work in a public registry, and none
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