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Motor cortex stimulation for pain control induces changes in the endogenous opioid system

https://doi.org/10.1212/01.wnl.0000269783.86997.37
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29/29 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 29 checked references that resolve
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Algorithm for neuropathic pain treatment: An evidence based proposal
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Precentral Cortex Stimulation for the Treatment of Central Neuropathic Pain
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Motor cortex stimulation for phantom limb pain
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Motor cortex stimulation for refractory neuropathic pain: Four year outcome and predictors of efficacy
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Treatment of Thalamic Pain by Chronic Motor Cortex Stimulation
resolves10.1016/S0304-3959(99)00114-1
Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study
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Functional Imaging and Neurophysiological Assessment of Spinal and Brain Therapeutic Modulation in Humans
resolves10.1016/j.brainres.2004.12.043
Spinal dorsal horn neuron response to mechanical stimuli is decreased by electrical stimulation of the primary motor cortex
resolves10.1016/0304-3959(94)00211-V
Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study
resolves10.1016/j.neuroimage.2006.08.037
Motor cortex stimulation in neuropathic pain. Correlations between analgesic effect and hemodynamic changes in the brain. A PET study
resolves10.1016/0304-3940(91)90362-W
In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography
resolves10.1126/science.1067176
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
resolves10.3171/jns.1988.68.1.0099
Localization of human sensorimotor cortex during surgery by cortical surface recording of somatosensory evoked potentials
resolves10.1016/0969-8043(94)90217-8
Automated radiosyntheses of [6-O-methyl-11C]diprenorphine and [6-O-methyl-11C]buprenorphine from 3-O-trityl protected precursors
resolves10.1016/j.pain.2006.10.013
Differential brain opioid receptor availability in central and peripheral neuropathic pain
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Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study
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A Possible involvement of the central endorphin system in the autoanalgesia induced by chronic administration of freundʼs adjuvant solution in rats
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Gender and Age Influences on Human Brain Mu-Opioid Receptor Binding Measured by PET
resolves10.1016/j.ejpain.2003.11.017
Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [<sup>11</sup>C]diprenorphine binding and PET
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What to learn from in vivo opioidergic brain imaging?
resolves10.1016/j.brainres.2004.07.055
Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells
resolves10.1016/0304-3959(78)90037-4
Endorphins in chronic pain. I. Differences in CSF endorphin levels between organic and psychogenic pain syndromes
resolves10.1016/0304-3959(91)90218-M
Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF
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CSF enkephalins in diabetic neuropathy
resolves10.1007/BF00238343
Projections of precentral and premotor cortex to the red nucleus and other midbrain areas in macaca fascicularis
resolves10.1002/cne.903630408
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
The 6 references without a DOI — listed, not checked
no DOI — not checkedFields HL, Adams JE. Pain after cortical injury by electrical stimulation of the internal capsule. Brain 1974;97:169–178.
no DOI — not checkedFrost JJ, Douglass KH, Mayberg HS, et al. Multicompartmental analysis of [11C]carfentanil binding to opiate receptors in humans measured by positron emission tomography. J Cereb Blood Flow Metab 1989;9:398–409.
no DOI — not checkedMillan MJ, Millan MH, Czlonkowski A, et al. A model of chronic pain in the rat: response of multiple opioid systems to adjuvant-induced arthritis. J Neurosci 1986;6:899–906.
no DOI — not checkedFields H. State-dependent opioid control of pain. Nat Rev Neurosci 2004;5:565–575.
no DOI — not checkedClement-Jones V, Tomlin S, Rees LH, McLoughlin L, Besser GM, Wen HL. Increased β-endorphin but not met-enkephalin levels in human cerebrospinal fluid after acupuncture for recurrent pain. Lancet 1980;ii:946–948.
no DOI — not checkedDehen H, Amsallem B, Colas-Linhart N. Cerebrospinal fluid beta-endorphin in chronic pain in man [in French]. Rev Neurol (Paris) 1990;146:155–157.
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